Rhiza Labs FluTracker Forum

The week 8 FluView reports a dramatic spike in H3N2 low reactors in the United States.

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Influenza A (H3N2) [407]
•Three hundred nineteen (78.4%) of the 407 viruses were characterized as A/Perth/16/2009-like, the influenza A (H3N2) component of the 2011-2012 influenza vaccine for the Northern Hemisphere.
•Eighty-eight viruses (21.6%) tested showed reduced titers with antiserum produced against A/Perth/16/2009.

http://www.cdc.gov/flu/weekly/

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Above is week 8. Below is week 7
Influenza A (H3N2) [291]
•Two hundred seventy-seven (95.2%) of the 291 viruses were characterized as A/Perth/16/2009-like, the influenza A (H3N2) component of the 2011-2012 influenza vaccine for the Northern Hemisphere.
•Fourteen viruses (4.8%) tested showed reduced titers with antiserum produced against A/Perth/16/2009.http://www.cdc.gov/flu/weekly/weeklyarchives2011-2012/weekly07.htm

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The above numbers indicate 116 H3N2 isolates were tested for week 8, and 74 were LOW REACTORS (63.8%)

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22 2012 H3N2 CDC sequences at GISAID
A/Massachusetts/02/2012 EPI_ISL_105768 H3N2 M1/C1 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-23
A/Virginia/03/2012 EPI_ISL_105762 H3N2 M1/C1 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-23
A/Montana/01/2012 EPI_ISL_105800 H3N2 M1/C1 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-17
A/Missouri/02/2012 EPI_ISL_105759 H3N2 C1 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-17
A/Virginia/01/2012 EPI_ISL_103756 H3N2 C1 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-17
A/Texas/10/2012 EPI_ISL_105770 H3N2 C2 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-16
A/Idaho/02/2012 EPI_ISL_105764 H3N2 M1/C1 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-16
A/Vermont/01/2012 EPI_ISL_103750 H3N2 M1/C1 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-16
A/Georgia/01/2012 EPI_ISL_105760 H3N2 M1/C1 --- --- --- 1701 --- --- 984 --- --- --- Garten, Rebecca 2012-01-15
A/Nebraska/01/2012 EPI_ISL_103752 H3N2 C1 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-14
A/Kansas/01/2012 EPI_ISL_105766 H3N2 C2 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-11
A/Arkansas/01/2012 EPI_ISL_103758 H3N2 C2 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-11
A/Washington/01/2012 EPI_ISL_103751 H3N2 C1 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-11
A/Wyoming/01/2012 EPI_ISL_105763 H3N2 C2 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-10
A/Nevada/01/2012 EPI_ISL_103754 H3N2 M1/C1 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-10
A/Florida/02/2012 EPI_ISL_103742 H3N2 C1 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-09
A/Texas/06/2012 EPI_ISL_103749 H3N2 M1/C1 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-05
A/California/01/2012 EPI_ISL_103747 H3N2 C2 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-04
A/South Carolina/01/2012 EPI_ISL_103141 H3N2 X1/C2 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-04
A/Iowa/01/2012 EPI_ISL_103746 H3N2 C2 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-03
A/Wisconsin/01/2012 EPI_ISL_102984 H3N2 C2 --- --- --- 1701 --- 1410 982 --- --- --- Garten, Rebecca 2012-01-02
A/Utah/04/2012 EPI_ISL_105767 H3N2 C2 --- --- --- 1701 --- 1410 984 --- --- --- Garten, Rebecca 2012-01-01

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See recent H3N2 sequences with H3N2v acquisiitions (via recombination).

viewtopic.php?f=5&t=7993

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A/South Carolina/01/2012 has multiple H3N2v acquisitions in HA and MP sequences.

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Commentary
http://www.recombinomics.com/News/03021 ... plode.html

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New H3N2 vaccine target most related

EPI353906 A/Victoria/361/2011 (A/H3N2) segment 4 (HA) 3142.3 0.000000e+00 1701/1701 (100%)
EPI349106 A/Victoria/361/2011 (A/H3N2) segment 4 (HA) 3125.7 0.000000e+00 1698/1701 (99%)
EPI349103 A/Victoria/361/2011 (A/H3N2) segment 4 (HA) 3125.7 0.000000e+00 1698/1701 (99%)
EPI346296 A/TASMANIA/26/2011 (A/H3N2) segment 4 (HA) 3114.6 0.000000e+00 1696/1701 (99%)
EPI342318 A/Hong Kong/3953/2011 (A/H3N2) segment 4 (HA) 3109.0 0.000000e+00 1695/1701 (99%)
EPI341583 A/American Samoa/7102/2011 (A/H3N2) segment 4 (HA) 3109.0 0.000000e+00 1695/1701 (99%)
EPI335951 A/South Australia/03/2011 (A/H3N2) segment 4 (HA) 3109.0 0.000000e+00 1695/1701 (99%)
EPI333049 A/VICTORIA/528/2011 (A/H3N2) segment 4 (HA) 3109.0 0.000000e+00 1695/1701 (99%)
EPI333046 A/SOUTH AUSTRALIA/3/2011 (A/H3N2) segment 4 (HA) 3109.0 0.000000e+00 1695/1701 (99%)
EPI331091 A/Hong Kong/3968/2011 (A/H3N2) segment 4 (HA) 3109.0 0.000000e+00 1695/1701 (99%)
EPI319687 A/Hong Kong/3953/2011 (A/H3N2) segment 4 (HA) 3109.0 0.000000e+00 1695/1701 (99%)
EPI342321 A/Hong Kong/3953/2011 (A/H3N2) segment 4 (HA) 3103.5 0.000000e+00 1694/1701 (99%)
EPI342315 A/Hong Kong/3953/2011 (A/H3N2) segment 4 (HA) 3103.5 0.000000e+00 1694/1701 (99%)
EPI340961 A/Indonesia/NIHRD-DRS013/2011(H3N2) (A/H3N2) segment 4 (HA) 3103.5 0.000000e+00 1694/1701 (99%)
EPI346299 A/SOUTH AUSTRALIA/206/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI335701 A/CANKIRI/TR-56/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI331255 A/Taiwan/1328/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI331093 A/Hong Kong/3969/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI331081 A/Slovenia/507/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI331067 A/Johannesburg/27/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI309737 A/Netherlands/34/2010 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI353555 A/Stockholm/2/2012 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI352685 A/Stockholm/32/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI351639 A/Stockholm/43/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI347899 A/Hunan-Linwu/58/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI347846 A/Hunan-Suxian/1331/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI347571 A/Stockholm/32/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI346597 A/England/253/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI346393 A/ENG/253/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI346320 A/NONTHABURI/110/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI346314 A/PERTH/81/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI342678 A/Stockholm/25/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI335714 A/Norway/1789/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI335712 A/Norway/1789/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI335702 A/ANTALYA/TR-55/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI332697 A/Norway/1789/2011 (A/H3N2) segment 4 (HA) 3092.4 0.000000e+00 1692/1701 (99%)
EPI355957 A/Finland/190/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI353930 A/Latvia/1-47850/2012 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI353928 A/Latvia/12-47890/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI353485 A/Hong Kong/4913/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI352830 A/Catalonia/S4468/2012 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI352824 A/Catalonia/S4451/2012 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI352732 A/Belgium/G1109/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI352689 A/Berlin/87/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI352200 A/Hunan-Linwu/58/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI350935 A/Catalonia/S4410/2012 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI347937 A/Hunan-Suxian/1370/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI347907 A/Guangdong-Dongguanbendi/5388/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI347901 A/Hunan-Yueyanglou/1320/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI347844 A/Hunan-Suxian/1319/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI347526 A/North Carolina/10/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI346591 A/Bratislava/31/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI346452 A/Chonburi/269/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI346317 A/CHIANG RAI/108/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI341343 A/Finland/189/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI335697 A/Slovenia/537/2011 (A/H3N2) segment 4 (HA) 3086.9 0.000000e+00 1691/1701 (99%)
EPI354168 A/Bremen/1/2012 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI354156 A/Switzerland/5834718/2012 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI354154 A/Switzerland/5834715/2012 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352837 A/Catalonia/S4485/2012 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352827 A/Catalonia/S4454/2012 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352775 A/Hong Kong/5047/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352771 A/Hong Kong/4960/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352705 A/Berlin/92/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352703 A/Berlin/91/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352701 A/Berlin/89/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352699 A/Berlin/88/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352695 A/Berlin/85/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352691 A/Berlin/86/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352191 A/Shanghai-Luwan/1440/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI349752 A/North Carolina/11/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI347933 A/Shanghai-Putuo/1621/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI347903 A/Shandong-Tianqiao/1188/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI347842 A/Beijing-Xicheng/11542/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI347580 A/Karlstad/3/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI347538 A/Taiwan/1462/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI347472 A/Beijing-Xicheng/11542/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI346458 A/Nonthaburi/279/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI341577 A/California/23/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI331507 A/VICTORIA/803/2011 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI276927 A/NEWCASTLE/4/2010 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI352716 A/Castilla La Mancha/RR8843/2011 (A/H3N2) segment 4 (HA) 3077.6 0.000000e+00 1689/1701 (99%)
EPI348478 A/Chiang Rai/277/2011 (A/H3N2) segment 4 (HA) 3077.6 0.000000e+00 1689/1701 (99%)
EPI346455 A/Chiang Rai/277/2011 (A/H3N2) segment 4 (HA) 3077.6 0.000000e+00 1689/1701 (99%)
EPI355960 A/Virginia/03/2012 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI354164 A/Berlin/3/2012 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI354138 A/Turkey/01/11 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI353934 A/Latvia/1-49852/2012 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI353921 A/Finland/197/2012 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI352811 A/Ghom/9677/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI352793 A/Algeria/G05/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI352781 A/Berlin/94/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI352769 A/Hong Kong/4974/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI352730 A/Stockholm/23/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI352697 A/Algeria/G04/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI352687 A/Stockholm/34/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI351727 A/Ostersund/2/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI349758 A/California/35/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI349379 A/Oregon/09/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI347588 A/Stockholm/34/2011 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)

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Maryland death cluster due to a drift variant

viewtopic.php?f=5&t=8026

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