Rhiza Labs FluTracker Forum

The CDC FluView continues to issue a weekly report, even though it is not flu season. Although the underlying data on sub-types can change due to updates, the latest data shows an increase in H3 cases (3 in each of the past 3 weeks), as well as one unsubtypable in week 33 (the only unsubtypable reported for the past 46 weeks).

These increases may reflect a low level of detection of trH3N2.

Latest data for the past 10 weeks:

25 0 0 0 0 0 2 1666 0.12
26 0 2 0 0 1 1 1281 0.31
27 0 2 1 0 1 1 1232 0.41
28 0 0 3 0 0 3 1196 0.5
29 0 0 3 0 0 5 1204 0.66
30 0 0 0 0 2 1 1015 0.3
31 0 3 0 0 3 2 1074 0.74
32 0 0 3 0 6 2 1064 1.03
33 0 1 3 1 7 1 1074 1.21
34 0 0 3 0 4 1 839 0.95

http://www.cdc.gov/flu/weekly/weeklyarc ... regt34.htm

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Data for the past 46 weeks

40 0 7 17 0 29 23 3723 2.04
41 0 13 38 0 43 35 4102 3.14
42 0 8 35 0 53 46 4245 3.35
43 0 13 55 0 47 53 4346 3.87
44 0 12 61 0 68 105 4741 5.19
45 0 15 76 0 95 164 5540 6.32
46 0 23 122 0 109 238 5781 8.51
47 0 11 152 0 158 267 5645 10.42
48 0 34 181 0 133 260 6194 9.82
49 0 46 356 0 131 309 6341 13.28
50 0 83 544 0 278 525 7546 18.95
51 0 97 777 0 447 664 7979 24.88
52 0 190 981 0 532 655 9067 26.01
01 0 326 1160 0 591 573 10497 25.25
02 0 546 1193 0 686 598 10243 29.51
03 0 822 1411 0 745 730 11096 33.42
04 0 1050 1479 0 936 965 12903 34.33
05 0 1203 1431 0 1113 1125 13727 35.49
06 0 1247 1456 0 1163 1176 14536 34.69
07 0 1415 1524 0 1421 1382 16306 35.21
08 0 1137 1211 0 1021 1203 14316 31.94
09 0 951 997 0 749 890 12888 27.83
10 0 667 801 0 510 696 11327 23.61
11 0 437 572 0 379 558 9636 20.2
12 0 258 418 0 271 406 8295 16.31
13 0 175 280 0 173 286 6933 13.18
14 0 88 196 0 93 252 6358 9.89
15 0 46 141 0 57 149 5298 7.42
16 0 30 55 0 28 79 4362 4.4
17 0 9 27 0 29 61 3699 3.41
18 0 11 18 0 10 23 3145 1.97
19 0 2 11 0 8 14 2908 1.2
20 0 0 5 0 4 10 2611 0.73
21 0 2 4 0 6 4 2348 0.68
22 0 1 0 0 5 5 2043 0.54
23 0 0 0 0 1 4 1869 0.27
24 0 2 1 0 6 0 1745 0.52
25 0 0 0 0 0 2 1666 0.12
26 0 2 0 0 1 1 1281 0.31
27 0 2 1 0 1 1 1232 0.41
28 0 0 3 0 0 3 1196 0.5
29 0 0 3 0 0 5 1204 0.66
30 0 0 0 0 2 1 1015 0.3
31 0 3 0 0 3 2 1074 0.74
32 0 0 3 0 6 2 1064 1.03
33 0 1 3 1 7 1 1074 1.21
34 0 0 3 0 4 1 839 0.95

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It is worth noting that the reporting of an unsubtypable by the CDC is EXTREMELY rare. Although trH3N2 isolates have human H3 and N2, the genes are from the 1990's and have extensively evolved in swine in the past 15 years. This evolution could produce an unsubtypable (unable to subtype) result. Most trH3N2 however, will type as seasonal H3N2 because of the jump of seasonal H3N2 into swine in the 1990's and the human lineage of the H3 and N2 in trH3N2.

In Australia type A influenza is dominated by swine H1N1. In the past 3 weeks, the CDC is reporting one H1N1 and 9 H3N2, raising concerns than some or most of the H3N2 isolates are trH3N2.

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The unsubtypable in week 33 was NOT reported in the week 33 report

25 0 0 0 0 0 2 1651 0.12
26 0 2 0 0 1 1 1266 0.32
27 0 2 1 0 1 1 1200 0.42
28 0 0 3 0 0 3 1138 0.53
29 0 0 3 0 0 5 1166 0.69
30 0 0 0 0 2 1 966 0.31
31 0 3 0 0 3 2 889 0.9
32 0 0 3 0 6 2 848 1.3
33 0 0 2 0 3 0 657 0.76

http://www.cdc.gov/flu/weekly/weeklyarc ... regt33.htm

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Note that the unsubtyable in week 33 is NOT displayed in the week 34 graph

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Prior to this weekend, the CDC has not reported an unsubtypable since the 2009 H1N1 pandemic

http://www.cdc.gov/flu/weekly/weeklyarc ... regt20.htm

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Commentary

http://www.recombinomics.com/News/09051 ... pable.html

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The unsubtypable sample from week 33 is probably the trH3n2 case from Pennsylvania (see new thread at link below)

viewtopic.php?f=5&t=7467

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