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PostPosted: Fri Sep 02, 2011 10:06 pm 
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New Swine Flu in 2 U.S. Kids
New Bug Has Gene From Pandemic Swine Flu; No Sign Yet of Human Spread
By Daniel J. DeNoon
WebMD Health NewsReviewed by Laura J. Martin, MD Sept. 2, 2011 -- Two U.S. kids -- an Indiana boy and a Pennsylvania girl -- are the first human cases of a new swine flu bug.

Both kids fully recovered after suffering usual flu symptoms.

The two children had no contact with each other. Each caught the new flu in separate transmission events. The boy's case was reported on Aug. 17; the girl's on Aug. 24.

"We have been able to detect a novel flu virus," CDC spokesman Tom Skinner tells WebMD. "It is an H3N2 swine flu virus that has picked up a gene from 2009 H1N1. We are investigating whether human-to-human spread is occurring."

Human-to-human spread appears possible, as the boy seems to have been infected by a caretaker who had contact with pigs. But so far there's no evidence of sustained person-to-person spread. A preliminary investigation in Indiana found no spread of the virus beyond the infected boy.

This is far from the first time humans may have caught swine flu viruses directly from pigs. The CDC knows of 21 cases from December 2005 to December 2010.

But it's the first time the 2009 swine flu virus currently circulating in humans has recombined with an older swine flu bug. The new flu is a reassortment in which the old swine H3N2 virus incorporates a single structural gene from the 2009 H1N1 virus, says CDC virologist Mike Shaw, PhD.

This 2009 H1N1 gene is unlikely to make the bug cause more severe disease or to make it more easy to catch, he tells WebMD.

Preventing Swine Flu
Pigs actually got the H3N2 virus from humans. It's the flu bug that caused human disease in the 1990s.

Because the "H" and "N" components of flu bugs stimulate immune responses, many adults may already have at least partial immunity to the new H3N2 swine flu.

Not so for children. Both of the kids who came down with the new bug were under 5 years of age.

Both kids got their flu shots last September -- but it did not protect them against the new swine flu. The CDC confirms that the current flu shot is not expected to protect against the new virus.

While human spread doesn't yet seem to be happening, the CDC is on high alert. It's not yet flu season, but it is state fair season.

Shaw warns that people who come into contact with pigs -- particularly children -- may be susceptible to the new bug. People especially susceptible to flu -- including very young kids, pregnant women, the elderly, and people with suppressed immune systems -- should avoid contact with swine.

Why? If pigs in Pennsylvania and Indiana are infected, it's likely that pigs across North America are carrying the new flu bug.

"It is almost like the entire swine population in North America is one big herd," Shaw says. "That is because of movement the animals at many stages of production from breeding to slaughter."

People cannot get any kind of swine flu bug from eating pork.

http://www.webmd.com/cold-and-flu/news/ ... RSS_PUBLIC

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PostPosted: Fri Sep 02, 2011 10:08 pm 
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Two U.S. children develop flu from pigs, U.S. government researchers say
Julie Steenhuysen
CHICAGO— Globe and Mail Update
Published Friday, Sep. 02, 2011 6:58PM EDT
Last updated Friday, Sep. 02, 2011 7:02PM EDT

Two U.S. children were infected with flu viruses that originated in pigs in the past two months, and an analysis of both viruses showed they had picked up genetic material from the 2009 pandemic influenza A H1N1 virus, government researchers said Friday.

They issued a warning to health workers to watch out for suspect viruses because those that cross between species can be especially virulent.

In both children, one from Indiana and one from Pennsylvania, an analysis of the viruses showed they contained a gene of the 2009 pandemic flu virus, according to a report released by the U.S. Center for Disease Control and Prevention.

Flu viruses that jump from one species to another are a concern because they can swap genes and form an entirely new virus, making them harder to protect against.

“Pandemic viruses get started when they reassert and they emerge as a new virus. That is why we have to keep close watch on new influenza viruses as they emerge,” CDC spokesman Tom Skinner said.

“They are constantly changing, and that is why we have to have really good surveillance systems in place to detect them when they do emerge,” he said.

So far, this new virus does not appear to be able to easily pass from human to human, but Mr. Skinner said the CDC is still investigating.

Since 2005, there have been about 22 cases of human infection from swine-origin influenza viruses similar to the cases now being reported, Mr. Skinner said. All 22 people have recovered.

In one of the two new cases, a young boy from Indiana who had gotten a flu vaccine last September developed fever, cough, shortness of breath, diarrhea and a sore throat in late July. He was taken to the emergency department and a swab of his throat indicated that he had been infected by an influenza A virus.

The boy was sent home untreated but returned to the hospital the next day to be admitted and treated for multiple chronic health conditions, which had gotten worse because of his infection.

The boy recovered and was sent home, but further testing by state officials suggested his virus had originated in pigs, and his sample was sent to the CDC for confirmation.

According to the CDC report, the child had no prior direct contact with pigs, but a child-care worker who looked after the boy did report having contact with pigs before the child’s symptoms appeared.

In the second case, a Pennsylvania girl under age 5 who had received a flu shot the prior year developed a suspected infection with swine-origin influenza A (H3N2) in August.

Later testing by state officials and the CDC confirmed that she, too, had developed a form of flu that originated in pigs, likely from direct contact at an agricultural fair.

The girl was not treated and has completely recovered.

So far, the CDC has not seen any additional cases of people developing a pig form of influenza, but Mr. Skinner said the CDC is publishing the report to remind doctors and health workers to be watchful for suspicious cases of flu.

The H1N1 pandemic flu strain was discovered in Mexico and the United States in March 2009 and spread rapidly across the world. The World Health Organization estimates about 18,450 people died from the virus up to August 2010, including many pregnant women and young people.

Seasonal flu vaccines being offered across the world protect against the H1N1 strain. Flu vaccines are made by several drugmakers including Glaxosmithkline, Sanofi and Novartis.

http://www.theglobeandmail.com/life/hea ... le2152626/

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PostPosted: Fri Sep 02, 2011 10:28 pm 
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http://www.portal.state.pa.us/portal/se ... 090211_pdf

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PostPosted: Fri Sep 02, 2011 10:30 pm 
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niman wrote:
http://www.portal.state.pa.us/portal/server.pt/document/1159869/novel_influenza_a_virus_q%2Ba_090211_pdf

How unique are these cases?
These cases are similar to previous, limited human infections with swine‐origin H3N2 viruses, but unique in that they contain a genetic component of the 2009 influenza A H1N1 virus.
About the Investigation in Pennsylvania
The CDC is the lead on this investigation. Their international influenza experts are working closely with state and local investigators, and the CDC’s laboratory is providing very specialized analyses. The investigation is focused on determining patterns of influenza‐like illness, doing laboratory testing for influenza virus, increasing surveillance and alerting health care providers to this case to assist with reporting efforts. Together, we are continuing to investigate the origin of this influenza strain and whether or not human‐to‐human transmission is occurring.

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PostPosted: Fri Sep 02, 2011 10:31 pm 
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niman wrote:
niman wrote:
http://www.portal.state.pa.us/portal/server.pt/document/1159869/novel_influenza_a_virus_q%2Ba_090211_pdf

How unique are these cases?
These cases are similar to previous, limited human infections with swine‐origin H3N2 viruses, but unique in that they contain a genetic component of the 2009 influenza A H1N1 virus.
About the Investigation in Pennsylvania
The CDC is the lead on this investigation. Their international influenza experts are working closely with state and local investigators, and the CDC’s laboratory is providing very specialized analyses. The investigation is focused on determining patterns of influenza‐like illness, doing laboratory testing for influenza virus, increasing surveillance and alerting health care providers to this case to assist with reporting efforts. Together, we are continuing to investigate the origin of this influenza strain and whether or not human‐to‐human transmission is occurring.

Should I be watching for any specific symptoms?
Symptoms experienced in the patient in Pennsylvania were similar to that of seasonal influenza, and included fever, lethargy, lack of appetite and coughing. Other influenza symptoms may also include a runny nose, sore throat, eye irritation, nausea, vomiting and diarrhea.

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PostPosted: Fri Sep 02, 2011 10:51 pm 
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niman wrote:
Novel Influenza A Virus:
These viruses are genetically related, but different enough to suggest there was not a common source of infection. No epidemiologic link between these two cases has been identified.
http://www.cdc.gov/flu/weekly/

The sequence of A/Indiana/18/2011 is public. The PA sequence is not. The Indian sequence is the only known sequence with trH3N2 with MP pandemic H1N1. The H3 of swine isolates from Indiana and North Carolina is very closely related to the human case, but the swine isolates have a trH3N2 MP. The fact that both human isolates have pandemic H1N1 MP signals transmission. the above differences raise concerns that this novel constellation is widespread in humans.

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PostPosted: Fri Sep 02, 2011 11:13 pm 
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niman wrote:
niman wrote:
Novel Influenza A Virus:
These viruses are genetically related, but different enough to suggest there was not a common source of infection. No epidemiologic link between these two cases has been identified.
http://www.cdc.gov/flu/weekly/

The sequence of A/Indiana/18/2011 is public. The PA sequence is not. The Indian sequence is the only known sequence with trH3N2 with MP pandemic H1N1. The H3 of swine isolates from Indiana and North Carolina is very closely related to the human case, but the swine isolates have a trH3N2 MP. The fact that both human isolates have pandemic H1N1 MP signals transmission. the above differences raise concerns that this novel constellation is widespread in humans.

Top 100 HA matches at GISAID:
EPI333152 A/Indiana/08/2011 (A/H3N2) segment 4 (HA) 3142.3 0.000000e+00 1701/1701 (100%)
EPI324857 A/swine/North Carolina/A01049436/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI317003 A/swine/Indiana/A0109091/2010 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI293965 A/Minnesota/11/2010 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI291898 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI328900 A/Minnesota/11/2010 X-203A (A/H3N2) segment 4 (HA) 3070.3 0.000000e+00 1688/1701 (99%)
EPI312980 A/Pennsylvania/40/2010 (A/H3N2) segment 4 (HA) 3070.3 0.000000e+00 1688/1701 (99%)
EPI328898 A/Minnesota/11/2010 X-203 (A/H3N2) segment 4 (HA) 3064.7 0.000000e+00 1687/1701 (99%)
EPI291838 A/Minnesota/09/2010 (A/H3N2) segment 4 (HA) 2996.4 0.000000e+00 1658/1676 (98%)
EPI291893 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 2922.5 0.000000e+00 1606/1618 (99%)
EPI222910 A/swine/Minnesota/7931/2007 (A/H3N2) segment 4 (HA) 2881.9 0.000000e+00 1656/1703 (97%)
EPI314335 A/turkey/BC/1529-3/2005 (A/H3N2) segment 4 (HA) 2854.2 0.000000e+00 1651/1703 (96%)
EPI103199 A/swine/Ontario/33853/2005 (A/H3N2) segment 4 (HA) 2854.2 0.000000e+00 1651/1703 (96%)
EPI103127 A/Ontario/RV1273/2005 (A/H3N2) segment 4 (HA) 2854.2 0.000000e+00 1651/1703 (96%)
EPI229372 A/turkey/OH/313053/2004 (A/H3N2) segment 4 (HA) 2848.7 0.000000e+00 1650/1703 (96%)
EPI103181 A/swine/Manitoba/12707/2005 (A/H3N2) segment 4 (HA) 2843.1 0.000000e+00 1649/1703 (96%)
EPI103145 A/swine/Alberta/14722/2005 (A/H3N2) segment 4 (HA) 2843.1 0.000000e+00 1649/1703 (96%)
EPI101389 A/turkey/Ohio/313053/04 (A/H3N2) segment 4 (HA) 2843.1 0.000000e+00 1649/1703 (96%)
EPI289638 A/swine/Minnesota/1300/2007 (A/H3N2) segment 4 (HA) 2832.0 0.000000e+00 1647/1703 (96%)
EPI158876 A/turkey/MN/366767/2005 (A/H3N2) segment 4 (HA) 2832.0 0.000000e+00 1647/1703 (96%)
EPI228922 A/turkey/Illinois/2004 (A/H3N2) segment 4 (HA) 2815.4 0.000000e+00 1645/1704 (96%)
EPI168645 A/turkey/Minnesota/366767/2005 (A/H3N2) segment 4 (HA) 2815.4 0.000000e+00 1645/1704 (96%)
EPI103217 A/turkey/Ontario/31232/2005 (A/H3N2) segment 4 (HA) 2815.4 0.000000e+00 1645/1704 (96%)
EPI227574 A/turkey/NC/353568/2005 (A/H3N2) segment 4 (HA) 2804.3 0.000000e+00 1642/1703 (96%)
EPI168650 A/turkey/North Carolina/353568/2005 (A/H3N2) segment 4 (HA) 2804.3 0.000000e+00 1642/1703 (96%)
EPI166252 A/swine/Minnesota/SG-00234/2005 (A/H3N2) segment 4 (HA) 2796.9 0.000000e+00 1633/1691 (96%)
EPI225756 A/swine/Minnesota/66853/2006 (A/H3N2) segment 4 (HA) 2793.3 0.000000e+00 1640/1703 (96%)
EPI98712 A/swine/MI/PU243/04 (A/H3N1) segment 4 (HA) 2789.6 0.000000e+00 1638/1702 (96%)
EPI182817 A/swine/Quebec/4001/2005 (A/H3N2) segment 4 (HA) 2787.7 0.000000e+00 1639/1703 (96%)
EPI222756 A/swine/Minnesota/1145/2007 (A/H3N2) segment 4 (HA) 2782.2 0.000000e+00 1638/1703 (96%)
EPI128344 A/Ontario/1252/2007 (A/H3N2) segment 4 (HA) 2782.2 0.000000e+00 1638/1703 (96%)
EPI103163 A/swine/British Columbia/28103/2005 (A/H3N2) segment 4 (HA) 2782.2 0.000000e+00 1639/1704 (96%)
EPI166255 A/swine/Minnesota/SG-00235/2007 (A/H3N2) segment 4 (HA) 2780.3 0.000000e+00 1630/1691 (96%)
EPI166258 A/swine/Minnesota/SG-00236/2007 (A/H3N2) segment 4 (HA) 2778.5 0.000000e+00 1629/1690 (96%)
EPI225758 A/swine/Minnesota/66960/2006 (A/H3N2) segment 4 (HA) 2776.6 0.000000e+00 1637/1703 (96%)
EPI222674 A/swine/Oklahoma/008722/2007 (A/H3N2) segment 4 (HA) 2776.6 0.000000e+00 1637/1703 (96%)
EPI184448 A/swine/North Carolina/R08-001877-D08-013371/2008 (A/H3N2) segment 4 (HA) 2776.6 0.000000e+00 1638/1704 (96%)
EPI314635 A/swine/QC/2108-2/2009 (A/H3N2) segment 4 (HA) 2771.1 0.000000e+00 1636/1703 (96%)
EPI225753 A/swine/Minnesota/65767/2006 (A/H3N2) segment 4 (HA) 2771.1 0.000000e+00 1636/1703 (96%)
EPI222959 A/swine/Minnesota/578/2007 (A/H3N2) segment 4 (HA) 2771.1 0.000000e+00 1637/1704 (96%)
EPI222657 A/swine/Minnesota/5947/2007 (A/H3N2) segment 4 (HA) 2765.6 0.000000e+00 1635/1703 (96%)
EPI166278 A/swine/Minnesota/SG-00242/2006 (A/H3N2) segment 4 (HA) 2765.6 0.000000e+00 1629/1694 (96%)
EPI309154 A/swine/Pennsylvania/62170-3/2010 (A/H3N2) segment 4 (HA) 2760.0 0.000000e+00 1633/1702 (95%)
EPI309153 A/swine/Pennsylvania/62170-1/2010 (A/H3N2) segment 4 (HA) 2760.0 0.000000e+00 1633/1702 (95%)
EPI259504 A/swine/Minnesota/03008/2010 (A/H3N2) segment 4 (HA) 2754.5 0.000000e+00 1634/1704 (95%)
EPI222961 A/swine/Minnesota/761/2007 (A/H3N2) segment 4 (HA) 2754.5 0.000000e+00 1634/1704 (95%)
EPI182824 A/mink/Nova Scotia/1055488/2007 (A/H3N2) segment 4 (HA) 2754.5 0.000000e+00 1633/1703 (95%)
EPI314679 A/swine/QC/414/2009 (A/H3N2) segment 4 (HA) 2750.8 0.000000e+00 1634/1704 (95%)
EPI317007 A/swine/Iowa/A0109112/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1634/1705 (95%)
EPI291872 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1631/1702 (95%)
EPI291870 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1631/1702 (95%)
EPI291865 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1631/1702 (95%)
EPI318106 A/swine/Iowa/A01049185/2010 (A/H3N2) segment 4 (HA) 2743.4 0.000000e+00 1632/1704 (95%)
EPI318095 A/swine/Iowa/A01049113/2010 (A/H3N2) segment 4 (HA) 2743.4 0.000000e+00 1633/1705 (95%)
EPI312689 A/swine/Minnesota/239105/2009 (A/H3N2) segment 4 (HA) 2743.4 0.000000e+00 1629/1701 (95%)
EPI324844 A/swine/Nebraska/A01049235/2010 (A/H3N2) segment 4 (HA) 2737.9 0.000000e+00 1632/1705 (95%)
EPI314796 A/swine/Pennsylvania/602170-4/2010 (A/H3N2) segment 4 (HA) 2737.9 0.000000e+00 1629/1702 (95%)
EPI222682 A/swine/Oklahoma/011506/2007 (A/H3N2) segment 4 (HA) 2737.9 0.000000e+00 1630/1703 (95%)
EPI324851 A/swine/Iowa/A01049317/2010 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1629/1704 (95%)
EPI324849 A/swine/Iowa/A01049254/2010 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1628/1703 (95%)
EPI314666 A/swine/QC/1698-2/2009 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1629/1704 (95%)
EPI314665 A/swine/QC/1698-1/2009 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1629/1704 (95%)
EPI314667 A/swine/QC/1698-4/2009 (A/H3N2) segment 4 (HA) 2721.2 0.000000e+00 1628/1704 (95%)
EPI314643 A/swine/QC/382/2009 (A/H3N2) segment 4 (HA) 2721.2 0.000000e+00 1627/1703 (95%)
EPI316991 A/swine/Iowa/A0109035/2010 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1624/1701 (95%)
EPI316990 A/swine/Iowa/A0109034/2010 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1624/1701 (95%)
EPI314668 A/swine/QC/1698-5/2009 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1627/1704 (95%)
EPI307943 A/swine/Iowa/A01057188/2010 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1628/1705 (95%)
EPI314795 A/swine/Pennsylvania/602170-2/2010 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1624/1702 (95%)
EPI302647 A/swine/Illinois/53612-2/2009 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1626/1704 (95%)
EPI302646 A/swine/Illinois/53612-1/2009 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1626/1704 (95%)
EPI244297 A/Kansas/13/2009 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1626/1704 (95%)
EPI25393 A/turkey/ Minnesota/764-2/03 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1627/1705 (95%)
EPI314687 A/swine/QC/1840-2/2009 (A/H3N2) segment 4 (HA) 2706.5 0.000000e+00 1623/1701 (95%)
EPI314663 A/swine/QC/1685-1/2009 (A/H3N2) segment 4 (HA) 2704.6 0.000000e+00 1624/1703 (95%)
EPI230035 A/swine/Wisconsin/R7c/2001 (A/H3N2) segment 4 (HA) 2704.6 0.000000e+00 1626/1705 (95%)
EPI25391 A/turkey/North Carolina/12344/03 (A/H3N2) segment 4 (HA) 2704.6 0.000000e+00 1626/1705 (95%)
EPI314695 A/swine/QC/440-A/2009 (A/H3N2) segment 4 (HA) 2695.4 0.000000e+00 1625/1706 (95%)
EPI314664 A/swine/QC/1685-5/2009 (A/H3N2) segment 4 (HA) 2693.5 0.000000e+00 1622/1703 (95%)
EPI219360 A/swine/Kansas/015252/2009 (A/H3N2) segment 4 (HA) 2693.5 0.000000e+00 1622/1703 (95%)
EPI314515 A/quail/QC/FAV-10/2008 (A/H3N2) segment 4 (HA) 2688.0 0.000000e+00 1620/1702 (95%)
EPI324850 A/swine/Pennsylvania/A01049256/2010 (A/H3N2) segment 4 (HA) 2684.3 0.000000e+00 1622/1705 (95%)
EPI292016 A/swine/Iowa/H03BF5/2003 (A/H3N2) segment 4 (HA) 2678.8 0.000000e+00 1623/1707 (95%)
EPI324852 A/swine/Minnesota/A01049346/2010 (A/H3N2) segment 4 (HA) 2676.9 0.000000e+00 1620/1704 (95%)
EPI307945 A/swine/Illinois/A01057088/2010 (A/H3N2) segment 4 (HA) 2676.9 0.000000e+00 1622/1706 (95%)
EPI302658 A/swine/Illinois/53612-5/2009 (A/H3N2) segment 4 (HA) 2676.9 0.000000e+00 1621/1705 (95%)
EPI318101 A/swine/Iowa/A01049160/2010 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1622/1707 (95%)
EPI307944 A/swine/Illinois/A01057087/2010 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1621/1706 (95%)
EPI302653 A/swine/Illinois/53612-4/2009 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1620/1705 (95%)
EPI219368 A/swine/Oklahoma/001142/2009 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1618/1703 (95%)
EPI98686 A/swine/Minnesota/00395/2004 (A/H3N1) segment 4 (HA) 2665.8 0.000000e+00 1619/1705 (94%)
EPI314161 A/swine/Quebec/1265553/2010 (A/H3N2) segment 4 (HA) 2660.3 0.000000e+00 1611/1695 (95%)
EPI302664 A/swine/Illinois/53612-7/2010 (A/H3N2) segment 4 (HA) 2660.3 0.000000e+00 1619/1706 (94%)
EPI302659 A/swine/Illinois/53612-6/2010 (A/H3N2) segment 4 (HA) 2660.3 0.000000e+00 1618/1705 (94%)
EPI316988 A/swine/Iowa/A0109031/2010 (A/H3N2) segment 4 (HA) 2654.8 0.000000e+00 1618/1706 (94%)
EPI316989 A/swine/Iowa/A0109032/2010 (A/H3N2) segment 4 (HA) 2651.1 0.000000e+00 1617/1706 (94%)
EPI318097 A/swine/Indiana/A01049124/2010 (A/H3N2) segment 4 (HA) 2632.6 0.000000e+00 1614/1706 (94%)
EPI131612 A/swine/Wisconsin/H03HO7/2003 (A/H3N2) segment 4 (HA) 2632.6 0.000000e+00 1614/1706 (94%)
EPI161141 A/Hong Kong/CUHK4147/1997 (A/H3N2) segment 4 (HA) 2621.5 0.000000e+00 1613/1707 (94%)
EPI98728 A/swine/IN/PU542/04 (A/H3N1) segment 4 (HA) 2621.5 0.000000e+00 1612/1706 (94%)

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PostPosted: Fri Sep 02, 2011 11:18 pm 
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CDC has linked MMWR early release to its SOIV website

http://www.cdc.gov/flu/swineflu/soiv_cases.htm

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PostPosted: Sat Sep 03, 2011 3:14 am 
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'Swine flu' detected in Indiana boy
Rare virus is no cause for alarm, state health official says
12:29 AM, Sep. 3, 2011 A new strain of "swine flu" has shown up in two young children in Pennsylvania and Indiana who had direct or indirect contact with pigs.

So far, there's no sign the virus has spread beyond the two cases, the Centers for Disease Control and Prevention reported Friday.

"We wanted to provide some information without being alarmist," because people have contact with pigs at fairs this time of year and doctors should watch for possible flu cases, said Lyn Finelli, the CDC's flu surveillance chief. "We're always concerned when we see transmission of animal viruses to humans."

People rarely get flu from pigs -- only 21 cases have been documented in the past five years -- and it's too soon to know how infectious this virus will be, Finelli said.

This particular virus has only been seen eight times in the past five years -- the Indiana case was the ninth and the Pennsylvania case the 10th, according to the CDC's Morbidity and Mortality Weekly Report on Friday.

In Indiana, the virus was picked up as part of routine flu surveillance, said Shawn Richards, respiratory epidemiologist for the Indiana State Department of Health.

A boy younger than 5, who had chronic health problems, went to the hospital with flu symptoms on July 23. Richards declined to say where the case occurred.

When the boy's flu test came back positive, the state's virology lab requested the specimen, as it's unusual to see the disease at this time of year, Richards said. The lab found the flu strain to be nonhuman and sent it to the CDC.

The boy had had no contact with pigs, but a caretaker did in the weeks before he fell ill. She was asymptomatic, Richards said. No other family members appear ill.

In the Pennsylvania case, a girl, also younger than 5, had contact with pigs at an agricultural fair last month. She, too, has recovered, and health officials are investigating reports of illness in other people who went to the fair. No additional cases have been confirmed so far.

The viruses in the two children were similar but not identical, and Richards said there was no indication of a connection between the two cases.

Despite the rarity of such cases, there's no reason for alarm, health officials say.

"It's more of an intriguing, interesting thing," Richard said. "What it has told us is that our surveillance systems are working very well."

Studies showed that the virus includes a gene from the 2009 pandemic strain that might let it spread more easily than pig viruses normally do.

The new strain is a hybrid of viruses that have infected pigs over the past decade and a gene from the H1N1 strain that caused the pandemic two years ago. It is the first combination virus to turn up in people since the pandemic, said Michael Shaw, a lab chief at the CDC. It's classified as an H3N2 virus.

The gene from the 2009 pandemic is one of the things that makes this new strain worrisome, said Dr. John Treanor, a flu specialist at the University of Rochester School of Medicine.

"There is some evidence that that gene is particularly important for transmission from person to person," he said.

This year's vaccine, which is the same as last year's, likely would not protect against the new swine strain, Treanor and Finelli said. However, they are encouraged that so far it does not appear to have spread easily between people, and that local health officials detected and reported the novel strain so quickly.

Star reporter Shari Rudavsky and The Associated Press contributed to this story.

http://www.indystar.com/article/2011090 ... ext%7CNews

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PostPosted: Sat Sep 03, 2011 3:52 am 
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Location: Pittsburgh, PA USA
niman wrote:
CDC has linked MMWR early release to its SOIV website

http://www.cdc.gov/flu/swineflu/soiv_cases.htm

The updated CDC site has strategically ignored the MMWR report on the Minnesota cluster

Reported Human Infections with Swine Origin Influenza Viruses (SOIV) in the United States since 2005
As of January 25, 2011, 20 cases of human infection with swine origin influenza viruses (SOIV) have been reported in the United States. These are viruses that normally infect pigs. Like human influenza viruses, there are different subtypes and strains of swine origin influenza viruses. The main swine viruses circulating in U.S. pigs in recent years are swine triple reassortant (tr) H1N1 influenza virus, trH3N2 virus and trH1N2 virus. Of the 20 human cases reported since 2005, 12 have been trH1N1 viruses, seven have been trH3N2 viruses and one has been a trH1N2 virus. All 20 persons infected with swine viruses recovered from their illness. Thirteen cases occurred in children (persons younger than 19) and 7 cases occurred in adults. In 16 cases, direct or indirect exposure to swine prior to onset of illness has been identified. Although no person-to-person transmission of swine influenza viruses has been laboratory confirmed in the investigation of these cases to date, some cases reported only exposure to ill persons and no exposure to live pigs. Thus, limited person-to-person is likely to have occurred.

Related Links & Past Reports
Swine-Origin Influenza A (H3N2) Virus Infection in Two Children — Indiana and Pennsylvania, July — August 2011. MMWR 2011; 60 (Early Release); 1-4.
Update: Influenza Activity — United States, October 3, 2010-February 5, 2011. MMWR 2011; 60(06):175-181
Update: Influenza Activity — United States, October 3, 2010-December 11, 2010. MMWR 2010; 59(50):1651-1655
December 17, 2010 “Have You Heard”
November 12, 2010 “Have You Heard”
Information about 11 cases occurring between 2005 and 2009 can be found in the New England Journal of Medicine article entitled “Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009” [262 KB, 10 pages]

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