Rhiza Labs FluTracker Forum

Tomorrow's MMWR (week 34) will have two current pandemic H3N2 (trH3N2) cases in Pennsylvania and Indiana. This is the second Indiana case in July/August and is the third Pennsylvania case.

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6034md_w

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Novel influenza A virus infections***


2


4


0


4


43,774


2


4


NN


PA (1), IN (1)

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6034md_w

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This is a record rate. Two reported cases in the same week sets a record for contempory cases, and these two cases bring the total to three trH3N2 cases in one month, including two in Indiana.

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The number of states with multiple trH3N2 cases continues to grow. This week's case raises the number in PA to three. Minnesota also has three, including a H2H cluster, while Indiana has reported two cases in a one month period (end of July to end of August, raising concerns more will be reported from Indiana).

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No updates at CDC website for novel swine infections in humans

http://www.cdc.gov/flu/swineflu/soiv_cases.htm

Reported Human Infections with Swine Origin Influenza Viruses (SOIV) in the United States since 2005

As of January 25, 2011, 20 cases of human infection with swine origin influenza viruses (SOIV) have been reported in the United States. These are viruses that normally infect pigs. Like human influenza viruses, there are different subtypes and strains of swine origin influenza viruses. The main swine viruses circulating in U.S. pigs in recent years are swine triple reassortant (tr) H1N1 influenza virus, trH3N2 virus and trH1N2 virus. Of the 20 human cases reported since 2005, 12 have been trH1N1 viruses, seven have been trH3N2 viruses and one has been a trH1N2 virus. All 20 persons infected with swine viruses recovered from their illness. Thirteen cases occurred in children (persons younger than 19) and 7 cases occurred in adults. In 16 cases, direct or indirect exposure to swine prior to onset of illness has been identified. Although no person-to-person transmission of swine influenza viruses has been laboratory confirmed in the investigation of these cases to date, some cases reported only exposure to ill persons and no exposure to live pigs. Thus, limited person-to-person is likely to have occurred.

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CDC has acknowledged H2H in cluster in MN (in MMWR), but has not updated the above website on the MN cluster, the 2nd and 3rd cases in PA, or the two recent cases in IN.

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Commentary

http://www.recombinomics.com/News/09021 ... IN_PA.html

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H3 sequences most closely related to the Indiana case reported in week 30 MMWR
http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6030md_w

EPI333152 A/Indiana/08/2011 (A/H3N2) segment 4 (HA) 3142.3 0.000000e+00 1701/1701 (100%)
EPI324857 A/swine/North Carolina/A01049436/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI317003 A/swine/Indiana/A0109091/2010 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI293965 A/Minnesota/11/2010 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI291898 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI328900 A/Minnesota/11/2010 X-203A (A/H3N2) segment 4 (HA) 3070.3 0.000000e+00 1688/1701 (99%)
EPI312980 A/Pennsylvania/40/2010 (A/H3N2) segment 4 (HA) 3070.3 0.000000e+00 1688/1701 (99%)
EPI328898 A/Minnesota/11/2010 X-203 (A/H3N2) segment 4 (HA) 3064.7 0.000000e+00 1687/1701 (99%)
EPI291838 A/Minnesota/09/2010 (A/H3N2) segment 4 (HA) 2996.4 0.000000e+00 1658/1676 (98%)
EPI291893 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 2922.5 0.000000e+00 1606/1618 (99%)

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Commentary

http://www.recombinomics.com/News/09021 ... lence.html

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