Rhiza Labs FluTracker Forum

It is increasingly likely that the 2nd 2011 reported trH3N2 case was the daughter of the index case in the Minnesota cluster. Thus. like the first 2011 case, the second 2011 case was infected in 2010 and reported months after the fact. This was also true for IA/16/2009 who was infected in September, investigated in November, and reported in January, 2010. This case also did not require hospitalization and had no reported contact with swine

http://www.recombinomics.com/News/01151 ... _Iowa.html

Swine H3N2 in Iowan Lacking Swine Exposure
Recombinomics Commentary 21:34
January 15, 2010


One case of human infection with a novel influenza A virus was reported by the Iowa Department of Public Health. The case patient had onset of symptoms in September 2009, but did not require hospitalization and has fully recovered. The virus was identified as swine influenza A (H3N2) and investigated in November 2009. No clear exposure to swine was identified, but no evidence of sustained human-to-human transmission with this virus was found.

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Isolate name: A/Iowa/16/2009
Isolate ID: EPI_ISL_83270
Passage details/history: Original
Type: A / H3N2
Lineage:
Sample information
Collection date: 2009-11-19
Host Human
Additional host information:
Zip code:
Patient status:
Last vaccinated:
In-vivo pathogenicity test:
Location: United States / Iowa
Additional location information: USA
Patient age: 12 Year(s)
Gender: Male

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Commentary

http://www.recombinomics.com/News/08061 ... elays.html

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http://www.cdc.gov/eid/content/17/6/1143.htm

Volume 17, Number 6–June 2011

Letter

Swine Influenza Virus A (H3N2) Infection in Human, Kansas, USA, 2009

Chad M. Cox, Daniel Neises, Rebecca J. Garten, Bill Bryant, Richard A. Hesse, Gary A. Anderson, Ingrid Trevino-Garrison, Bo Shu, Stephen Lindstrom, Alexander I. Klimov, and Lyn Finelli
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.M. Cox, R.J. Garten, B. Shu, S. Lindstrom, A.I. Klimov, L. Finelli); Kansas Department of Health and Environment, Topeka, Kansas, USA (D. Neises, I. Trevino-Garrison); Kansas Animal Health Department, Topeka (B. Bryant); and Kansas State Veterinary Diagnostic Laboratory, Manhattan, Kansas, USA (R.A. Hesse, G.A. Anderson)

Suggested citation for this article

To the Editor: Triple-reassortant swine influenza viruses (SIVs), which contain genes from human, swine, and avian influenza A viruses, have been enzootic among swine herds in the United States since the late 1990s (1). Although uncommon, occasional transmission of triple-reassortant SIVs from swine to humans has occurred (2–4). Before April 2009, only limited, nonsustained human-to-human transmission of SIVs had been reported (5–7). Although an animal source for pandemic (H1N1) 2009 virus has yet to be identified, the pandemic strain resulted from the reassortment of 2 different lineages of SIV (8).

On July 28, 2009, a 12-year-old Kansas boy sought treatment for fever, cough, and sore throat. Results of an influenza rapid antigen test were positive, and a specimen was sent to the Kansas Department of Health and Environment for further testing. Real-time reverse transcription PCR (rRT-PCR) testing determined the virus contained the surface hemagglutinin (HA) gene of influenza A (H3) and the internal nucleoprotein gene common to all triple-reassortant SIVs (9). The specimen was sent to the Centers for Disease Control and Prevention (Atlanta, GA, USA) on August 3 and identified as swine-origin influenza virus A (H3N2) by rRT-PCR and sequence analysis.

The patient reported that during July 23–25, 2009, he touched healthy-appearing swine multiple times while attending a county fair. The boy received a standard treatment course of oseltamivir and recovered completely. None of his 3 household contacts attended the fair, and none reported signs or symptoms of illness in the weeks afterward.

The Kansas Department of Health and Environment and the local health department collaborated with the county extension office to identify and interview swine exhibitors at the county fair, focusing on influenza symptoms among exhibitors and household contacts during the week before and after the fair. Twenty-seven (79%) of 34 exhibitors participated in the survey; none reported signs or symptoms of influenza-like illness, defined as fever (temperature >100°F) accompanied by either cough or sore throat. Two household contacts of separate exhibitors each reported a low-grade fever (<100°F) and sore throat in the week after the fair. Both touched swine while attending the fair. Both visited a physician's office; neither was tested for influenza; and symptoms of both resolved without treatment. The veterinarian overseeing the swine barn reported no signs of respiratory illness among the swine during the fair. Most swine exhibited were slaughtered at the fair's conclusion.

On August 7, the Kansas Animal Health Department collected nasal swab specimens and blood samples from 13 swine belonging to 7 exhibitors. All samples were delivered to the Kansas State Veterinary Diagnostic Laboratory for analysis by influenza matrix rRT-PCR and virus isolation on nasal swab samples and hemagglutination inhibition (HI) assays against classical swine influenza virus (H1N1) (A/swine/Iowa/73) and the prototype swine influenza virus (H3N2) (A/swine/Texas/98) on serum samples. In addition, the influenza virus (H3N2) "county fair" isolate, A/Kansas/13/2009 (H3N2), was sent from the Centers for Disease Control and Prevention, amplified, and used to develop a second HI assay that included the original swine serum samples as well as paired convalescent-phase samples from 3 of the swine (Table).

Influenza matrix RT-PCR and virus isolation on nasal swab samples were negative. HI assays demonstrated little or no antibody against the influenza (H1N1) indicator virus and low-level antibody reaction against the prototype swine influenza virus (H3N2). However, HI titers against the "county fair" influenza virus (H3N2) showed consistently elevated titers, which suggested that the animals might have been exposed to the virus 2 weeks earlier, during the time of the fair. The swine may have cleared the virus by the time the nasal swabs were collected, but without positive RT-PCR or virus isolation results, the situation remain inconclusive.
Appendix Figure. Phylogenetic tree of the hemagglutinin (HA) gene segment of influenza A (H3) viruses created by using the neighbor-joining method, nucleotide model of Kimura-2 parameters...


We compared the HA gene segment of A/Kansas/13/2009 (H3N2) with recent animal and human influenza (H3N2) viruses by using the neighbor-joining method, and it clustered with the HA from recent triple-reassortant SIV (H3N2) isolates (Appendix Figure) (10). A/Kansas/13/2009 (H3N2) shares >97% nucleotide identity with 2 swine viruses reported to have caused human infections, A/Ontario/RV1273/2005 and A/Ontario/1252/2007, and >90% nucleotide identity with currently circulating seasonal (H3N2) viruses, such as A/Perth/16/2009. Sequence analysis for the remaining 7 gene segments confirmed A/Kansas/13/2009 as triple-reassortant SIV (H3N2), belonging to the same lineages as the genes for the reference virus A/swine/Texas/98 (data not shown). A full genome sequence for A/Kansas/13/2009 (H3N2) has been submitted to GenBank (accession nos. GU937743–GU937750).

This case emphasizes the importance of epidemiologic and laboratory surveillance in areas where humans and swine are in close contact. When novel influenza A infection occurs in humans, joint investigations by local, state, and federal public health and animal health agencies are key to determining the source of infection and extent of transmission. The worldwide spread of pandemic (H1N1) 2009 virus emphasizes the ongoing public health threat of interspecies influenza transmission. Improved surveillance among swine may lead to early identification of novel viruses with pandemic potential and provide early opportunities to implement control measures.

Acknowledgments


We thank the staff of the Kansas State University Research and Extension, the Kansas State Veterinary Diagnostic Laboratory, the Kansas State Animal Health Department, the Riley County Health Department, and the Kansas Department of Health and Environment who coordinated this investigation.

References
1.Karasin AI, Schutten MM, Cooper LA, Smith CB, Subbarao K, Anderson GA, et al. Genetic characterization of H3N2 influenza viruses isolated from pigs in North America, 1977–1999: evidence for wholly human and reassortant virus genotypes.Virus Res. 2000;68:71–85. PubMed DOI
2.Newman AP, Reisdorf E, Beinemann J, Uyeki TM, Balish A, Shu B, et al. Human case of swine influenza A (H1N1) triple reassortant virus infection, Wisconsin. Emerg Infect Dis. 2008;14:1470–2. PubMed DOI
3.Olsen CW, Karasin AI, Carman S, Li Y, Bastien N, Ojkic D, et al. Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerg Infect Dis. 2006;12:1132–5.
4.Shinde V, Bridges CB, Uyeki TM, Shu B, Balish A, Xu X, et al. Triple-reassortant swine influenza A (H1) in humans in the United States, 2005–2009.N Engl J Med. 2009;360:2616–25. PubMed DOI
5.Robinson JL, Lee BE, Patel J, Bastien N, Grimsrud K, Seal RF, et al. Swine influenza (H3N2) infection in a child and possible community transmission, Canada. Emerg Infect Dis. 2007;13:1865–70.
6.Wells DL, Hopfensperger DJ, Arden NH, Harmon MW, Davis JP, Tipple MA, et al. Swine influenza virus infections. Transmission from ill pigs to humans at a Wisconsin agricultural fair and subsequent probable person-to-person transmission. JAMA. 1991;265:478–81. PubMed DOI
7.Top FH Jr, Russell PK. Swine influenza A at Fort Dix, New Jersey (January–February 1976). IV. Summary and speculation. J Infect Dis. 1977;136(Suppl):S376–80. PubMed DOI
8.Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, et al. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009;325:197–201. PubMed DOI
9.World Health Organization. CDC protocol of real-time RTPCR for influenza A (H1N1). 2009 April 30, 2009 [cited 2010 July 6]; http://www.who.int/csr/resources/public ... index.html
10.Tamura K, Dudley J, Nei M, Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007;24:1596–9. PubMed DOI

Figure

Appendix Figure. Phylogenetic tree of the hemagglutinin (HA) gene segment of influenza A (H3) viruses created by using the neighbor-joining method, nucleotide model of Kimura-2 parameters...

Table

Table. Hemagglutination inhibition assay titers for 3 influenza strains from swine exhibited at county fair, by date of blood draw, Kansas, 2009

Suggested Citation for this Article

Cox CM, Neises D, Garten RJ, Bryant B, Hesse RA, Anderson GA, et al. Swine influenza virus A (H3N2) infection in human, Kansas, USA, 2009 [letter]. Emerg Infect Dis [serial on the Internet]. 2011 Jun [date cited]. http://www.cdc.gov/EID/content/17/6/1143.htm

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The above tree is just the tip of the trH3N2 iceburg. Sequences for all (or most) of the eight gene segments for A/Iowa/16/2009, A/Minnesota/09/2010, A/Pennsylvania/40/2010, A/Wisconsin/12/2010, A/Pennsylvania/14/2010, A/Minnesota/11/2010, and A/Minnesota/11/2010 vaccine sequences are public and at GISAID.
H3 sequences for PA/40/2010, WI/12/2010, and MN/11/2010 are VERY closley related (and NS sequences are IDENTICAL).

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Top HA matches for Kansas/13/2009 (human tr H3N2 highlighted)

EPI302647 A/swine/Illinois/53612-2/2009 (A/H3N2) segment 4 (HA) 1463.7 0.000000e+00 792/792 (100%)
EPI302646 A/swine/Illinois/53612-1/2009 (A/H3N2) segment 4 (HA) 1463.7 0.000000e+00 792/792 (100%)
EPI244297 A/Kansas/13/2009 (A/H3N2) segment 4 (HA) 1463.7 0.000000e+00 792/792 (100%)
EPI244055 A/swine/Illinois/02945/2010 (A/H3N2) segment 4 (HA) 1402.7 0.000000e+00 775/783 (98%)
EPI222959 A/swine/Minnesota/578/2007 (A/H3N2) segment 4 (HA) 1402.7 0.000000e+00 781/792 (98%)
EPI184448 A/swine/North Carolina/R08-001877-D08-013371/2008 (A/H3N2) segment 4 (HA) 1386.1 0.000000e+00 778/792 (98%)
EPI324849 A/swine/Iowa/A01049254/2010 (A/H3N2) segment 4 (HA) 1380.6 0.000000e+00 777/792 (98%)
EPI289638 A/swine/Minnesota/1300/2007 (A/H3N2) segment 4 (HA) 1375.0 0.000000e+00 776/792 (97%)
EPI180194 A/swine/Minnesota/24877/2005 (A/H3N2) segment 4 (HA) 1369.5 0.000000e+00 775/792 (97%)
EPI180193 A/swine/Minnesota/21057/2005 (A/H3N2) segment 4 (HA) 1369.5 0.000000e+00 775/792 (97%)
EPI103199 A/swine/Ontario/33853/2005 (A/H3N2) segment 4 (HA) 1369.5 0.000000e+00 775/792 (97%)
EPI103181 A/swine/Manitoba/12707/2005 (A/H3N2) segment 4 (HA) 1369.5 0.000000e+00 775/792 (97%)
EPI103127 A/Ontario/RV1273/2005 (A/H3N2) segment 4 (HA) 1369.5 0.000000e+00 775/792 (97%)
EPI269537 A/swine/Iowa/03017/2010 (A/H3N2) segment 4 (HA) 1365.8 0.000000e+00 763/775 (98%)
EPI103145 A/swine/Alberta/14722/2005 (A/H3N2) segment 4 (HA) 1365.8 0.000000e+00 773/790 (97%)
EPI314335 A/turkey/BC/1529-3/2005 (A/H3N2) segment 4 (HA) 1363.9 0.000000e+00 774/792 (97%)
EPI182817 A/swine/Quebec/4001/2005 (A/H3N2) segment 4 (HA) 1363.9 0.000000e+00 774/792 (97%)
EPI158876 A/turkey/MN/366767/2005 (A/H3N2) segment 4 (HA) 1363.9 0.000000e+00 774/792 (97%)
EPI103217 A/turkey/Ontario/31232/2005 (A/H3N2) segment 4 (HA) 1363.9 0.000000e+00 775/793 (97%)
EPI103163 A/swine/British Columbia/28103/2005 (A/H3N2) segment 4 (HA) 1363.9 0.000000e+00 775/793 (97%)
EPI229372 A/turkey/OH/313053/2004 (A/H3N2) segment 4 (HA) 1358.4 0.000000e+00 773/792 (97%)
EPI222961 A/swine/Minnesota/761/2007 (A/H3N2) segment 4 (HA) 1358.4 0.000000e+00 773/792 (97%)
EPI168645 A/turkey/Minnesota/366767/2005 (A/H3N2) segment 4 (HA) 1358.4 0.000000e+00 773/792 (97%)
EPI101389 A/turkey/Ohio/313053/04 (A/H3N2) segment 4 (HA) 1358.4 0.000000e+00 773/792 (97%)
EPI225753 A/swine/Minnesota/65767/2006 (A/H3N2) segment 4 (HA) 1352.9 0.000000e+00 772/792 (97%)
EPI180192 A/swine/Minnesota/18815/2005 (A/H3N2) segment 4 (HA) 1352.9 0.000000e+00 772/792 (97%)
EPI166258 A/swine/Minnesota/SG-00236/2007 (A/H3N2) segment 4 (HA) 1352.9 0.000000e+00 772/792 (97%)
EPI166255 A/swine/Minnesota/SG-00235/2007 (A/H3N2) segment 4 (HA) 1352.9 0.000000e+00 772/792 (97%)
EPI180116 A/swine/North Carolina/63607-38/2008 (A/H3N2) segment 4 (HA) 1338.1 0.000000e+00 762/781 (97%)
EPI228922 A/turkey/Illinois/2004 (A/H3N2) segment 4 (HA) 1336.2 0.000000e+00 769/792 (97%)
EPI225756 A/swine/Minnesota/66853/2006 (A/H3N2) segment 4 (HA) 1336.2 0.000000e+00 769/792 (97%)
EPI180191 A/swine/Iowa/36241/2005 (A/H3N2) segment 4 (HA) 1336.2 0.000000e+00 769/792 (97%)
EPI166252 A/swine/Minnesota/SG-00234/2005 (A/H3N2) segment 4 (HA) 1336.2 0.000000e+00 770/793 (97%)
EPI227574 A/turkey/NC/353568/2005 (A/H3N2) segment 4 (HA) 1330.7 0.000000e+00 768/792 (96%)
EPI180148 A/swine/North Carolina/38715/2005 (A/H3N2) segment 4 (HA) 1330.7 0.000000e+00 768/792 (96%)
EPI180126 A/swine/Iowa/36243/2005 (A/H3N2) segment 4 (HA) 1330.7 0.000000e+00 768/792 (96%)
EPI168650 A/turkey/North Carolina/353568/2005 (A/H3N2) segment 4 (HA) 1330.7 0.000000e+00 768/792 (96%)
EPI98712 A/swine/MI/PU243/04 (A/H3N1) segment 4 (HA) 1330.7 0.000000e+00 768/792 (96%)
EPI180073 A/swine/Illinois/63607-2/2008 (A/H3N2) segment 4 (HA) 1327.0 0.000000e+00 761/782 (97%)
EPI316989 A/swine/Iowa/A0109032/2010 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 767/792 (96%)
EPI316988 A/swine/Iowa/A0109031/2010 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 767/792 (96%)
EPI307943 A/swine/Iowa/A01057188/2010 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 768/793 (96%)
EPI302659 A/swine/Illinois/53612-6/2010 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 767/792 (96%)
EPI302658 A/swine/Illinois/53612-5/2009 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 767/792 (96%)
EPI225758 A/swine/Minnesota/66960/2006 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 767/792 (96%)
EPI222674 A/swine/Oklahoma/008722/2007 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 767/792 (96%)
EPI128344 A/Ontario/1252/2007 (A/H3N2) segment 4 (HA) 1325.2 0.000000e+00 767/792 (96%)
EPI180077 A/swine/Iowa/225-9/2008 (A/H3) segment 4 (HA) 1321.5 0.000000e+00 761/784 (97%)
EPI324850 A/swine/Pennsylvania/A01049256/2010 (A/H3N2) segment 4 (HA) 1319.6 0.000000e+00 767/793 (96%)
EPI302653 A/swine/Illinois/53612-4/2009 (A/H3N2) segment 4 (HA) 1319.6 0.000000e+00 766/792 (96%)
EPI222756 A/swine/Minnesota/1145/2007 (A/H3N2) segment 4 (HA) 1319.6 0.000000e+00 766/792 (96%)
EPI222682 A/swine/Oklahoma/011506/2007 (A/H3N2) segment 4 (HA) 1319.6 0.000000e+00 766/792 (96%)
EPI166278 A/swine/Minnesota/SG-00242/2006 (A/H3N2) segment 4 (HA) 1319.6 0.000000e+00 766/792 (96%)
EPI180069 A/swine/Arkansas/63607-20/2008 (A/H3N2) segment 4 (HA) 1315.9 0.000000e+00 759/782 (97%)
EPI307945 A/swine/Illinois/A01057088/2010 (A/H3N2) segment 4 (HA) 1314.1 0.000000e+00 766/793 (96%)
EPI307944 A/swine/Illinois/A01057087/2010 (A/H3N2) segment 4 (HA) 1314.1 0.000000e+00 766/793 (96%)
EPI281211 A/swine/Illinois/03040/2010 (A/H3N2) segment 4 (HA) 1314.1 0.000000e+00 766/793 (96%)
EPI222657 A/swine/Minnesota/5947/2007 (A/H3N2) segment 4 (HA) 1314.1 0.000000e+00 765/792 (96%)
EPI180128 A/swine/Illinois/34642/2005 (A/H3N2) segment 4 (HA) 1314.1 0.000000e+00 765/792 (96%)
EPI180075 A/swine/Illinois/63607-36/2008 (A/H3N2) segment 4 (HA) 1310.4 0.000000e+00 758/782 (96%)
EPI318101 A/swine/Iowa/A01049160/2010 (A/H3N2) segment 4 (HA) 1308.5 0.000000e+00 764/792 (96%)
EPI314796 A/swine/Pennsylvania/602170-4/2010 (A/H3N2) segment 4 (HA) 1308.5 0.000000e+00 764/792 (96%)
EPI314635 A/swine/QC/2108-2/2009 (A/H3N2) segment 4 (HA) 1308.5 0.000000e+00 764/792 (96%)
EPI314152 A/swine/Quebec/1259260/2010 (A/H3N2) segment 4 (HA) 1308.5 0.000000e+00 764/792 (96%)
EPI309154 A/swine/Pennsylvania/62170-3/2010 (A/H3N2) segment 4 (HA) 1308.5 0.000000e+00 764/792 (96%)
EPI309153 A/swine/Pennsylvania/62170-1/2010 (A/H3N2) segment 4 (HA) 1308.5 0.000000e+00 764/792 (96%)
EPI302664 A/swine/Illinois/53612-7/2010 (A/H3N2) segment 4 (HA) 1308.5 0.000000e+00 765/793 (96%)
EPI281212 A/swine/Illinois/03041/2010 (A/H3N2) segment 4 (HA) 1306.7 0.000000e+00 757/782 (96%)
EPI318097 A/swine/Indiana/A01049124/2010 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 764/793 (96%)
EPI314687 A/swine/QC/1840-2/2009 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 763/792 (96%)
EPI314668 A/swine/QC/1698-5/2009 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 764/793 (96%)
EPI314667 A/swine/QC/1698-4/2009 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 764/793 (96%)
EPI314666 A/swine/QC/1698-2/2009 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 764/793 (96%)
EPI314665 A/swine/QC/1698-1/2009 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 764/793 (96%)
EPI291872 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 763/792 (96%)
EPI291870 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 763/792 (96%)
EPI291865 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 763/792 (96%)
EPI222910 A/swine/Minnesota/7931/2007 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 761/789 (96%)
EPI180079 A/swine/Iowa/63607-13/2008 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 756/781 (96%)
EPI180072 A/swine/Illinois/63607-18/2008 (A/H3N2) segment 4 (HA) 1303.0 0.000000e+00 755/780 (96%)
EPI314695 A/swine/QC/440-A/2009 (A/H3N2) segment 4 (HA) 1299.3 0.000000e+00 762/792 (96%)
EPI314643 A/swine/QC/382/2009 (A/H3N2) segment 4 (HA) 1297.5 0.000000e+00 762/792 (96%)
EPI180074 A/swine/Illinois/63607-22/2008 (A/H3N2) segment 4 (HA) 1293.8 0.000000e+00 755/782 (96%)
EPI314795 A/swine/Pennsylvania/602170-2/2010 (A/H3N2) segment 4 (HA) 1291.9 0.000000e+00 761/792 (96%)
EPI314679 A/swine/QC/414/2009 (A/H3N2) segment 4 (HA) 1291.9 0.000000e+00 760/790 (96%)
EPI182824 A/mink/Nova Scotia/1055488/2007 (A/H3N2) segment 4 (HA) 1291.9 0.000000e+00 761/792 (96%)
EPI314664 A/swine/QC/1685-5/2009 (A/H3N2) segment 4 (HA) 1275.3 0.000000e+00 758/792 (95%)
EPI314663 A/swine/QC/1685-1/2009 (A/H3N2) segment 4 (HA) 1275.3 0.000000e+00 758/792 (95%)
EPI219360 A/swine/Kansas/015252/2009 (A/H3N2) segment 4 (HA) 1275.3 0.000000e+00 756/789 (95%)
EPI180094 A/swine/Minnesota/63607-29/2008 (A/H3N2) segment 4 (HA) 1273.5 0.000000e+00 750/781 (96%)
EPI180080 A/swine/Iowa/63607-19/2008 (A/H3N2) segment 4 (HA) 1271.6 0.000000e+00 749/779 (96%)
EPI324852 A/swine/Minnesota/A01049346/2010 (A/H3N2) segment 4 (HA) 1269.8 0.000000e+00 758/793 (95%)
EPI318106 A/swine/Iowa/A01049185/2010 (A/H3N2) segment 4 (HA) 1269.8 0.000000e+00 757/792 (95%)
EPI291838 A/Minnesota/09/2010 (A/H3N2) segment 4 (HA) 1269.8 0.000000e+00 758/793 (95%)
EPI291813 A/Iowa/16/2009 (A/H3N2) segment 4 (HA) 1269.8 0.000000e+00 758/793 (95%)
EPI244116 A/swine/Illinois/02940/2010 (A/H3N2) segment 4 (HA) 1267.9 0.000000e+00 750/782 (95%)
EPI316991 A/swine/Iowa/A0109035/2010 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 757/793 (95%)
EPI316990 A/swine/Iowa/A0109034/2010 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 757/793 (95%)
EPI312689 A/swine/Minnesota/239105/2009 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 756/792 (95%)
EPI293965 A/Minnesota/11/2010 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 758/794 (95%)
EPI291898 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 758/794 (95%)
EPI291893 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 758/794 (95%)
EPI259504 A/swine/Minnesota/03008/2010 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 757/793 (95%)
EPI219368 A/swine/Oklahoma/001142/2009 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 754/789 (95%)
EPI99786 A/swine/Ontario/Biovet1/05 (A/H3N2) segment 4 (HA) 1264.2 0.000000e+00 716/732 (97%)
EPI180097 A/swine/Minnesota/63607-33/2008 (A/H3) segment 4 (HA) 1262.4 0.000000e+00 749/782 (95%)
EPI292016 A/swine/Iowa/H03BF5/2003 (A/H3N2) segment 4 (HA) 1260.5 0.000000e+00 757/794 (95%)
EPI180101 A/swine/Minnesota/63607-5/2008 (A/H3N1) segment 4 (HA) 1260.5 0.000000e+00 751/785 (95%)
EPI312980 A/Pennsylvania/40/2010 (A/H3N2) segment 4 (HA) 1258.7 0.000000e+00 757/794 (95%)
EPI230035 A/swine/Wisconsin/R7c/2001 (A/H3N2) segment 4 (HA) 1258.7 0.000000e+00 756/793 (95%)
EPI131612 A/swine/Wisconsin/H03HO7/2003 (A/H3N2) segment 4 (HA) 1258.7 0.000000e+00 756/793 (95%)
EPI99788 A/swine/Alberta/Biovet1/05 (A/H3N2) segment 4 (HA) 1258.7 0.000000e+00 715/732 (97%)
EPI25391 A/turkey/North Carolina/12344/03 (A/H3N2) segment 4 (HA) 1258.7 0.000000e+00 756/793 (95%)
EPI328900 A/Minnesota/11/2010 X-203A (A/H3N2) segment 4 (HA) 1253.1 0.000000e+00 756/794 (95%)
EPI328898 A/Minnesota/11/2010 X-203 (A/H3N2) segment 4 (HA) 1253.1 0.000000e+00 756/794 (95%)
EPI317003 A/swine/Indiana/A0109091/2010 (A/H3N2) segment 4 (HA) 1253.1 0.000000e+00 756/794 (95%)
EPI25393 A/turkey/ Minnesota/764-2/03 (A/H3N2) segment 4 (HA) 1253.1 0.000000e+00 755/793 (95%)
EPI324857 A/swine/North Carolina/A01049436/2011 (A/H3N2) segment 4 (HA) 1247.6 0.000000e+00 755/794 (95%)
EPI99784 A/swine/Quebec/Biovet1/05 (A/H3N2) segment 4 (HA) 1247.6 0.000000e+00 713/732 (97%)
EPI180121 A/swine/Oklahoma/225-14/2008 (A/H3N2) segment 4 (HA) 1243.9 0.000000e+00 748/785 (95%)
EPI98686 A/swine/Minnesota/00395/2004 (A/H3N1) segment 4 (HA) 1242.1 0.000000e+00 755/795 (94%)
EPI314515 A/quail/QC/FAV-10/2008 (A/H3N2) segment 4 (HA) 1236.5 0.000000e+00 752/793 (94%)
EPI324844 A/swine/Nebraska/A01049235/2010 (A/H3N2) segment 4 (HA) 1231.0 0.000000e+00 750/792 (94%)
EPI317007 A/swine/Iowa/A0109112/2010 (A/H3N2) segment 4 (HA) 1231.0 0.000000e+00 750/792 (94%)
EPI307929 A/swine/Pennsylvania/057108-1/2010 (A/H3N2) segment 4 (HA) 1231.0 0.000000e+00 750/792 (94%)
EPI180088 A/swine/Minnesota/63607-11/2008 (A/H3) segment 4 (HA) 1231.0 0.000000e+00 742/780 (95%)
EPI324851 A/swine/Iowa/A01049317/2010 (A/H3N2) segment 4 (HA) 1225.4 0.000000e+00 749/792 (94%)
EPI318095 A/swine/Iowa/A01049113/2010 (A/H3N2) segment 4 (HA) 1225.4 0.000000e+00 750/793 (94%)
EPI8003 A/Swine/Illinois/21587/99 (A/H3N2) segment 4 (HA) 1225.4 0.000000e+00 749/792 (94%)
EPI8007 A/Swine/Wisconsin/14094/99 (A/H3N2) segment 4 (HA) 1219.9 0.000000e+00 748/792 (94%)
EPI8005 A/Swine/Oklahoma/18089/99 (A/H3N2) segment 4 (HA) 1219.9 0.000000e+00 748/792 (94%)
EPI302652 A/swine/Illinois/53612-3/2009 (A/H3N2) segment 4 (HA) 1214.4 0.000000e+00 738/792 (93%)
EPI249982 A/swine/Missouri/02980/2010 (A/H3N2) segment 4 (HA) 1214.4 0.000000e+00 710/737 (96%)
EPI8001 A/Swine/Oklahoma/18717/99 (A/H3N2) segment 4 (HA) 1214.4 0.000000e+00 747/792 (94%)
EPI314161 A/swine/Quebec/1265553/2010 (A/H3N2) segment 4 (HA) 1208.8 0.000000e+00 748/794 (94%)
EPI180108 A/swine/North Carolina/225-7/2008 (A/H3N2) segment 4 (HA) 1208.8 0.000000e+00 742/785 (94%)
EPI246023 A/swine/Minnesota/02948/2009 (A/H3N2) segment 4 (HA) 1207.0 0.000000e+00 709/737 (96%)
EPI235271 A/swine/North Carolina/2003 (A/H3N2) segment 4 (HA) 1203.3 0.000000e+00 745/792 (94%)
EPI98746 A/Turkey/Canada-Manitoba/NS-01782-2/05 (A/H3) segment 4 (HA) 1203.3 0.000000e+00 683/699 (97%)
EPI98684 A/swine/Canada-BC/1A/05 (A/H3) segment 4 (HA) 1201.4 0.000000e+00 682/698 (97%)
EPI98573 A/turkey/Canada-BC/NS-01529-3/05 (A/H3) segment 4 (HA) 1201.4 0.000000e+00 682/698 (97%)
EPI292013 A/swine/Iowa/H03HB4/2003 (A/H3N2) segment 4 (HA) 1197.7 0.000000e+00 744/792 (93%)
EPI131610 A/swine/Wisconsin/H02AS8/2002 (A/H3N2) segment 4 (HA) 1197.7 0.000000e+00 745/793 (93%)
EPI91428 A/New York/518/1998 (A/H3N2) segment 4 (HA) 1197.7 0.000000e+00 744/792 (93%)
EPI30582 A/New York/587/1996 (A/H3N2) segment 4 (HA) 1197.7 0.000000e+00 744/792 (93%)
EPI30525 A/New York/581/1997 (A/H3N2) segment 4 (HA) 1197.7 0.000000e+00 744/792 (93%)
EPI30108 A/New York/579/1997 (A/H3N2) segment 4 (HA) 1197.7 0.000000e+00 744/792 (93%)

_________________
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Top 250 PB2 matches for Kansas/16/2009 (pandemic H1N1 isolates at the bottom with swl designation not highlighted)

EPI244298 A/Kansas/13/2009 (A/H3N2) segment 1 (PB2) 3779.4 0.000000e+00 2046/2046 (100%)
EPI323265 A/swine/Minnesota/66853/2006 (A/H3N2) segment 1 (PB2) 3663.0 0.000000e+00 2025/2046 (98%)
EPI291825 A/Michigan/09/2007 (A/H1N2) segment 1 (PB2) 3659.3 0.000000e+00 2024/2046 (98%)
EPI323254 A/swine/Minnesota/1300/2007 (A/H3N2) segment 1 (PB2) 3651.9 0.000000e+00 2023/2046 (98%)
EPI185085 A/swine/Minnesota/SG-00239/2007 (A/H1N2) segment 1 (PB2) 3651.9 0.000000e+00 2023/2046 (98%)
EPI166281 A/swine/Illinois/SG-00244/2007 (A/H1N1) segment 1 (PB2) 3651.9 0.000000e+00 2023/2046 (98%)
EPI291908 A/Ohio/02/2007 (A/H1N1) segment 1 (PB2) 3646.4 0.000000e+00 2022/2046 (98%)
EPI291860 A/Ohio/01/2007 (A/H1N1) segment 1 (PB2) 3646.4 0.000000e+00 2022/2046 (98%)
EPI173657 A/swine/OH/511445/2007 (A/H1N1) segment 1 (PB2) 3646.4 0.000000e+00 2022/2046 (98%)
EPI166279 A/swine/Minnesota/SG-00243/2006 (A/H3N2) segment 1 (PB2) 3646.4 0.000000e+00 2022/2046 (98%)
EPI153511 A/swine/Ohio/24366/07 (A/H1N1) segment 1 (PB2) 3646.4 0.000000e+00 2022/2046 (98%)
EPI323263 A/swine/Minnesota/578/2007 (A/H3N2) segment 1 (PB2) 3640.9 0.000000e+00 2021/2046 (98%)
EPI291791 A/Illinois/09/2007 (A/H1N1) segment 1 (PB2) 3640.9 0.000000e+00 2021/2046 (98%)
EPI281304 A/swine/Minnesota/02011/2008 (A/H1N2) segment 1 (PB2) 3640.9 0.000000e+00 2021/2046 (98%)
EPI281303 A/swine/Missouri/02060/2008 (A/H1N1) segment 1 (PB2) 3629.8 0.000000e+00 2019/2046 (98%)
EPI188115 A/swine/Illinois/Sg-00444/2008 (A/H1N1) segment 1 (PB2) 3624.2 0.000000e+00 2018/2046 (98%)
EPI188111 A/swine/Illinois/Sg-00443/2008 (A/H1N1) segment 1 (PB2) 3624.2 0.000000e+00 2018/2046 (98%)
EPI222635 A/swine/Kansas/77778/2007 (A/H1N1) segment 1 (PB2) 3618.7 0.000000e+00 2017/2046 (98%)
EPI184445 A/swine/North Carolina/R08-001877-D08-013371/2008 (A/H3N2) segment 1 (PB2) 3618.7 0.000000e+00 2018/2047 (98%)
EPI188119 A/swine/Illinois/Sg-00445/2008 (A/H1N1) segment 1 (PB2) 3613.2 0.000000e+00 2015/2046 (98%)
EPI281307 A/swine/Ohio/02026/2008 (A/H1N1) segment 1 (PB2) 3607.6 0.000000e+00 2015/2046 (98%)
EPI229379 A/turkey/OH/313053/2004 (A/H3N2) segment 1 (PB2) 3591.0 0.000000e+00 2012/2046 (98%)
EPI101403 A/turkey/Ohio/313053/04 (A/H3N2) segment 1 (PB2) 3591.0 0.000000e+00 2012/2046 (98%)
EPI227581 A/turkey/NC/353568/2005 (A/H3N2) segment 1 (PB2) 3579.9 0.000000e+00 2010/2046 (98%)
EPI291841 A/Minnesota/09/2010 (A/H3N2) segment 1 (PB2) 3568.8 0.000000e+00 2008/2046 (98%)
EPI314788 A/swine/Minnesota/A01047613/2010 (A/H1N1) segment 1 (PB2) 3563.3 0.000000e+00 2007/2046 (98%)
EPI302677 A/swine/Pennsylvania/62170-3/2010 (A/H3N2) segment 1 (PB2) 3563.3 0.000000e+00 2007/2046 (98%)
EPI295332 A/swine/South Dakota/152B/2009 (A/H1N2) segment 1 (PB2) 3563.3 0.000000e+00 2007/2046 (98%)
EPI291868 A/Pennsylvania/14/2010 (A/H3N2) segment 1 (PB2) 3563.3 0.000000e+00 2007/2046 (98%)
EPI312977 A/Pennsylvania/40/2010 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI312702 A/swine/North Carolina/239108/2010 (A/H1N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI302688 A/swine/Pennsylvania/62170-4/2010 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI302676 A/swine/Pennsylvania/62170-2/2010 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI302665 A/swine/Pennsylvania/62170-1/2010 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI291896 A/Wisconsin/12/2010 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI158873 A/turkey/MN/366767/2005 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2007/2047 (98%)
EPI103201 A/turkey/Ontario/31232/2005 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI103183 A/swine/Ontario/33853/2005 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI103147 A/swine/British Columbia/28103/2005 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI103111 A/Ontario/RV1273/2005 (A/H3N2) segment 1 (PB2) 3557.8 0.000000e+00 2006/2046 (98%)
EPI293962 A/Minnesota/11/2010 (A/H3N2) segment 1 (PB2) 3548.5 0.000000e+00 2005/2047 (97%)
EPI307926 A/swine/Pennsylvania/057108-1/2010 (A/H3N2) segment 1 (PB2) 3546.7 0.000000e+00 2004/2046 (97%)
EPI312654 A/swine/North Carolina/226124/2010 (A/H1N2) segment 1 (PB2) 3541.1 0.000000e+00 2003/2046 (97%)
EPI228919 A/turkey/Illinois/2004 (A/H3N2) segment 1 (PB2) 3541.1 0.000000e+00 2003/2046 (97%)
EPI182823 A/swine/Quebec/4001/2005 (A/H3N2) segment 1 (PB2) 3541.1 0.000000e+00 2003/2046 (97%)
EPI98706 A/swine/MI/PU243/04 (A/H3N1) segment 1 (PB2) 3541.1 0.000000e+00 2003/2046 (97%)
EPI312670 A/swine/North Carolina/226126/2010 (A/H1N2) segment 1 (PB2) 3535.6 0.000000e+00 2002/2046 (97%)
EPI312662 A/swine/North Carolina/226125/2010 (A/H1N2) segment 1 (PB2) 3535.6 0.000000e+00 2002/2046 (97%)
EPI166250 A/swine/Minnesota/SG-00234/2005 (A/H3N2) segment 1 (PB2) 3530.1 0.000000e+00 2001/2046 (97%)
EPI103165 A/swine/Manitoba/12707/2005 (A/H3N2) segment 1 (PB2) 3530.1 0.000000e+00 2002/2047 (97%)
EPI281298 A/swine/Texas/01976/2008 (A/H1N2) segment 1 (PB2) 3524.5 0.000000e+00 2000/2046 (97%)
EPI222649 A/swine/Minnesota/1145/2007 (A/H3N2) segment 1 (PB2) 3519.0 0.000000e+00 1999/2046 (97%)
EPI291853 A/Missouri/04/2006 (A/H1N1) segment 1 (PB2) 3513.4 0.000000e+00 1998/2046 (97%)
EPI222679 A/swine/Oklahoma/011506/2007 (A/H3N2) segment 1 (PB2) 3513.4 0.000000e+00 1998/2046 (97%)
EPI179351 A/swine/IL/07003243/2007 (A/H1N2) segment 1 (PB2) 3513.4 0.000000e+00 1998/2046 (97%)
EPI291794 A/Iowa/01/2006 (A/H1N1) segment 1 (PB2) 3507.9 0.000000e+00 1997/2046 (97%)
EPI220913 A/swine/Texas/008648/2008 (A/H1N2) segment 1 (PB2) 3507.9 0.000000e+00 1997/2046 (97%)
EPI220832 A/swine/Oklahoma/011521-5/2008 (A/H1N2) segment 1 (PB2) 3507.9 0.000000e+00 1998/2047 (97%)
EPI220824 A/swine/Oklahoma/011521-4/2008 (A/H1N2) segment 1 (PB2) 3507.9 0.000000e+00 1998/2047 (97%)
EPI220816 A/swine/Oklahoma/011289-9/2008 (A/H1N2) segment 1 (PB2) 3507.9 0.000000e+00 1998/2047 (97%)
EPI220808 A/swine/Oklahoma/011289-8/2008 (A/H1N2) segment 1 (PB2) 3507.9 0.000000e+00 1998/2047 (97%)
EPI220800 A/swine/Oklahoma/011289-10/2008 (A/H1N2) segment 1 (PB2) 3507.9 0.000000e+00 1998/2047 (97%)
EPI220784 A/swine/Oklahoma/010710-8/2008 (A/H1N2) segment 1 (PB2) 3507.9 0.000000e+00 1998/2047 (97%)
EPI166275 A/swine/Minnesota/SG-00242/2006 (A/H3N2) segment 1 (PB2) 3507.9 0.000000e+00 1997/2046 (97%)
EPI166253 A/swine/Minnesota/SG-00235/2007 (A/H3N2) segment 1 (PB2) 3507.9 0.000000e+00 1997/2046 (97%)
EPI153513 A/swine/Ohio/C62006/06 (A/H1N1) segment 1 (PB2) 3507.9 0.000000e+00 1997/2046 (97%)
EPI281308 A/swine/Iowa/02039/2008 (A/H1N2) segment 1 (PB2) 3502.4 0.000000e+00 1996/2046 (97%)
EPI220864 A/swine/Oklahoma/020734-3/2008 (A/H1N2) segment 1 (PB2) 3502.4 0.000000e+00 1997/2047 (97%)
EPI220848 A/swine/Oklahoma/016179-9/2008 (A/H1N2) segment 1 (PB2) 3502.4 0.000000e+00 1997/2047 (97%)
EPI220840 A/swine/Oklahoma/016179-8/2008 (A/H1N2) segment 1 (PB2) 3502.4 0.000000e+00 1997/2047 (97%)
EPI220792 A/swine/Oklahoma/010710-9/2008 (A/H1N2) segment 1 (PB2) 3502.4 0.000000e+00 1997/2047 (97%)
EPI323283 A/swine/Minnesota/7931/2007 (A/H3N2) segment 1 (PB2) 3496.8 0.000000e+00 1995/2046 (97%)
EPI220880 A/swine/Oklahoma/020736-2/2008 (A/H1N2) segment 1 (PB2) 3496.8 0.000000e+00 1996/2047 (97%)
EPI220872 A/swine/Oklahoma/020736-1/2008 (A/H1N2) segment 1 (PB2) 3496.8 0.000000e+00 1996/2047 (97%)
EPI220856 A/swine/Oklahoma/020734-2/2008 (A/H1N2) segment 1 (PB2) 3496.8 0.000000e+00 1996/2047 (97%)
EPI220768 A/swine/Oklahoma/010226-16/2008 (A/H1N2) segment 1 (PB2) 3496.8 0.000000e+00 1996/2047 (97%)
EPI166272 A/swine/Minnesota/SG-00241/2007 (A/H1N1) segment 1 (PB2) 3496.8 0.000000e+00 1995/2046 (97%)
EPI166269 A/swine/Minnesota/SG-00240/2007 (A/H1N1) segment 1 (PB2) 3496.8 0.000000e+00 1995/2046 (97%)
EPI166259 A/swine/Minnesota/SG-00237/2007 (A/H3N2) segment 1 (PB2) 3496.8 0.000000e+00 1995/2046 (97%)
EPI222671 A/swine/Oklahoma/008722/2007 (A/H3N2) segment 1 (PB2) 3491.3 0.000000e+00 1994/2046 (97%)
EPI220888 A/swine/Oklahoma/032726/2008 (A/H1N2) segment 1 (PB2) 3491.3 0.000000e+00 1995/2047 (97%)
EPI128360 A/Ontario/1252/2007 (A/H3N2) segment 1 (PB2) 3491.3 0.000000e+00 1994/2046 (97%)
EPI324032 A/swine/QC/1695-3/2009 (A/H1N1) segment 1 (PB2) 3485.7 0.000000e+00 1993/2046 (97%)
EPI220904 A/swine/Oklahoma/053259/2008 (A/H1N2) segment 1 (PB2) 3485.7 0.000000e+00 1994/2047 (97%)
EPI220896 A/swine/Oklahoma/042169/2008 (A/H1N2) segment 1 (PB2) 3485.7 0.000000e+00 1994/2047 (97%)
EPI220776 A/swine/Oklahoma/010226-17/2008 (A/H1N2) segment 1 (PB2) 3485.7 0.000000e+00 1994/2047 (97%)
EPI166256 A/swine/Minnesota/SG-00236/2007 (A/H3N2) segment 1 (PB2) 3485.7 0.000000e+00 1993/2046 (97%)
EPI323205 A/swine/Minnesota/65767/2006 (A/H3N2) segment 1 (PB2) 3480.2 0.000000e+00 1992/2046 (97%)
EPI291833 A/Minnesota/03/2008 (A/H1N1) segment 1 (PB2) 3474.7 0.000000e+00 1992/2047 (97%)
EPI281299 A/swine/Iowa/02096/2008 (A/H1N1) segment 1 (PB2) 3474.7 0.000000e+00 1991/2046 (97%)
EPI220921 A/swine/Texas/050593/2008 (A/H1N2) segment 1 (PB2) 3474.7 0.000000e+00 1992/2047 (97%)
EPI103129 A/swine/Alberta/14722/2005 (A/H3N2) segment 1 (PB2) 3474.7 0.000000e+00 1992/2047 (97%)
EPI324015 A/swine/QC/1531-3/2009 (A/H1N1) segment 1 (PB2) 3469.1 0.000000e+00 1990/2046 (97%)
EPI220929 A/swine/Texas/050625/2008 (A/H1N2) segment 1 (PB2) 3469.1 0.000000e+00 1991/2047 (97%)
EPI182830 A/mink/Nova Scotia/1055488/2007 (A/H3N2) segment 1 (PB2) 3469.1 0.000000e+00 1990/2046 (97%)
EPI98722 A/swine/IN/PU542/04 (A/H3N1) segment 1 (PB2) 3469.1 0.000000e+00 1990/2046 (97%)
EPI166263 A/swine/Minnesota/SG-00238/2006 (A/H1N1) segment 1 (PB2) 3465.4 0.000000e+00 1989/2046 (97%)
EPI314698 A/swine/QC/440-A/2009 (A/H3N2) segment 1 (PB2) 3458.0 0.000000e+00 1986/2043 (97%)
EPI291888 A/Texas/14/2008 (A/H1N1) segment 1 (PB2) 3447.0 0.000000e+00 1986/2046 (97%)
EPI219365 A/swine/Oklahoma/001142/2009 (A/H3N2) segment 1 (PB2) 3447.0 0.000000e+00 1987/2047 (97%)
EPI323975 A/swine/QC/398/2009 (A/H1N1) segment 1 (PB2) 3441.4 0.000000e+00 1986/2047 (97%)
EPI314646 A/swine/QC/382/2009 (A/H3N2) segment 1 (PB2) 3441.4 0.000000e+00 1986/2047 (97%)
EPI153512 A/swine/Ohio/75004/04 (A/H1N1) segment 1 (PB2) 3441.4 0.000000e+00 1985/2046 (97%)
EPI292053 A/swine/Iowa/H03LDH5/2003 (A/H3N2) segment 1 (PB2) 3435.9 0.000000e+00 1984/2046 (96%)
EPI281309 A/swine/Minnesota/02053/2008 (A/H1N1) segment 1 (PB2) 3435.9 0.000000e+00 1984/2046 (96%)
EPI281305 A/swine/Minnesota/02093/2008 (A/H1N1) segment 1 (PB2) 3435.9 0.000000e+00 1984/2046 (96%)
EPI219357 A/swine/Kansas/015252/2009 (A/H3N2) segment 1 (PB2) 3435.9 0.000000e+00 1985/2047 (96%)
EPI324093 A/swine/QC/3399-6/2009 (A/H1N1) segment 1 (PB2) 3430.3 0.000000e+00 1983/2046 (96%)
EPI324161 A/SW/MB/5-5/2009 (A/H1N1) segment 1 (PB2) 3424.8 0.000000e+00 1983/2047 (96%)
EPI292061 A/swine/Iowa/H02PW7/2002 (A/H1N1) segment 1 (PB2) 3424.8 0.000000e+00 1982/2046 (96%)
EPI292051 A/swine/Iowa/H03LS4/2003 (A/H1N1) segment 1 (PB2) 3424.8 0.000000e+00 1982/2046 (96%)
EPI281302 A/swine/North Carolina/02023/2008 (A/H1N1) segment 1 (PB2) 3424.8 0.000000e+00 1983/2047 (96%)
EPI281301 A/swine/North Carolina/02084/2008 (A/H1N1) segment 1 (PB2) 3424.8 0.000000e+00 1983/2047 (96%)
EPI324040 A/swine/QC/1697-1/2009 (A/H1N1) segment 1 (PB2) 3419.3 0.000000e+00 1983/2048 (96%)
EPI323198 A/swine/Minnesota/5947/2007 (A/H3N2) segment 1 (PB2) 3419.3 0.000000e+00 1981/2046 (96%)
EPI255759 A/swine/MN/48683/2002 (A/H1N1) segment 1 (PB2) 3419.3 0.000000e+00 1981/2046 (96%)
EPI323967 A/swine/QC/370/2009 (A/H1N1) segment 1 (PB2) 3408.2 0.000000e+00 1979/2046 (96%)
EPI314690 A/swine/QC/1840-2/2009 (A/H3N2) segment 1 (PB2) 3408.2 0.000000e+00 1979/2046 (96%)
EPI292060 A/swine/Iowa/H03BF5/2003 (A/H3N2) segment 1 (PB2) 3408.2 0.000000e+00 1979/2046 (96%)
EPI292057 A/swine/Iowa/H03G1/2003 (A/H1N1) segment 1 (PB2) 3408.2 0.000000e+00 1979/2046 (96%)
EPI291849 A/Minnesota/10/2009 (A/H1N1) segment 1 (PB2) 3408.2 0.000000e+00 1979/2046 (96%)
EPI255751 A/swine/MN/23506/2009 (A/H1N1) segment 1 (PB2) 3408.2 0.000000e+00 1979/2046 (96%)
EPI179343 A/swine/NC/00573/2005 (A/H1N1) segment 1 (PB2) 3408.2 0.000000e+00 1980/2047 (96%)
EPI15282 A/Swine/Korea/CY02/02 (A/H1N2) segment 1 (PB2) 3408.2 0.000000e+00 1980/2047 (96%)
EPI9471 A/Swine/Illinois/100084/01 (A/H1N2) segment 1 (PB2) 3408.2 0.000000e+00 1980/2047 (96%)
EPI292049 A/swine/Iowa/H03UWF2/2003 (A/H1N1) segment 1 (PB2) 3404.5 0.000000e+00 1978/2046 (96%)
EPI314638 A/swine/QC/2108-2/2009 (A/H3N2) segment 1 (PB2) 3402.6 0.000000e+00 1978/2046 (96%)
EPI292059 A/swine/Iowa/H02AS8/2002 (A/H3N2) segment 1 (PB2) 3402.6 0.000000e+00 1978/2046 (96%)
EPI246072 A/Saskatchewan/5351/2009 (A/H1N1 seasonal) segment 1 (PB2) 3402.6 0.000000e+00 1979/2047 (96%)
EPI246064 A/Saskatchewan/5350/2009 (A/H1N1 seasonal) segment 1 (PB2) 3402.6 0.000000e+00 1979/2047 (96%)
EPI246056 A/Saskatchewan/5131/2009 (A/H1N1 seasonal) segment 1 (PB2) 3402.6 0.000000e+00 1979/2047 (96%)
EPI179335 A/swine/IL/00685/2005 (A/H1N1) segment 1 (PB2) 3402.6 0.000000e+00 1979/2047 (96%)
EPI323992 A/swine/QC/1488-2/2009 (A/H1N1) segment 1 (PB2) 3399.0 0.000000e+00 1979/2048 (96%)
EPI324150 A/SW/SK/11-16/2009 (A/H1N1) segment 1 (PB2) 3397.1 0.000000e+00 1978/2047 (96%)
EPI164122 A/swine/Korea/CAS08/2005 (A/H1N1) segment 1 (PB2) 3395.3 0.000000e+00 1978/2047 (96%)
EPI291814 A/Iowa/16/2009 (A/H3N2) segment 1 (PB2) 3391.6 0.000000e+00 1977/2047 (96%)
EPI9469 A/Swine/Illinois/100085A/01 (A/H1N2) segment 1 (PB2) 3391.6 0.000000e+00 1976/2046 (96%)
EPI327290 A/swine/Texas/4199-2/1998 (A/H3N2) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI323273 A/swine/Minnesota/66960/2006 (A/H3N2) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI314682 A/swine/QC/414/2009 (A/H3N2) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI292054 A/swine/Iowa/H03HS5/2003 (A/H1N1) segment 1 (PB2) 3386.0 0.000000e+00 1975/2046 (96%)
EPI292050 A/swine/Iowa/H03US3/2003 (A/H1N1) segment 1 (PB2) 3386.0 0.000000e+00 1975/2046 (96%)
EPI185083 A/mallard/South Dakota/Sg-00128/2007 (A/H3N2) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI185081 A/mallard/South Dakota/Sg-00127/2007 (A/H3N2) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI185079 A/northern pintail/South Dakota/Sg-00126/2007 (A/H3N2) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI185076 A/mallard/South Dakota/Sg-00125/2007 (A/H3N2) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI164121 A/swine/Korea/CAN01/2004 (A/H1N1) segment 1 (PB2) 3386.0 0.000000e+00 1976/2047 (96%)
EPI323274 A/swine/Minnesota/761/2007 (A/H3N2) segment 1 (PB2) 3380.5 0.000000e+00 1975/2047 (96%)
EPI292063 A/swine/Iowa/H02NJ56371/2002 (A/H1N1) segment 1 (PB2) 3380.5 0.000000e+00 1975/2047 (96%)
EPI292052 A/swine/Iowa/H03LJ10/2003 (A/H1N1) segment 1 (PB2) 3376.8 0.000000e+00 1973/2046 (96%)
EPI292062 A/swine/Iowa/H02NJ56391/2002 (A/H1N1) segment 1 (PB2) 3374.9 0.000000e+00 1975/2048 (96%)
EPI222642 A/swine/Minnesota/07002083/2007 (A/H1N1) segment 1 (PB2) 3374.9 0.000000e+00 1974/2047 (96%)
EPI312686 A/swine/Minnesota/239105/2009 (A/H3N2) segment 1 (PB2) 3369.4 0.000000e+00 1972/2046 (96%)
EPI292055 A/swine/Iowa/H03HO7/2003 (A/H3N2) segment 1 (PB2) 3363.9 0.000000e+00 1971/2046 (96%)
EPI9457 A/Swine/Ohio/891/01 (A/H1N2) segment 1 (PB2) 3363.9 0.000000e+00 1972/2047 (96%)
EPI226727 A/Iowa/CEID23/2005 (A/H1N1) segment 1 (PB2) 3347.2 0.000000e+00 1968/2046 (96%)
EPI106786 A/swine/Korea/CN22/2006 (A/H3N1) segment 1 (PB2) 3336.2 0.000000e+00 1968/2048 (96%)
EPI98692 A/swine/Minnesota/00395/2004 (A/H3N1) segment 1 (PB2) 3336.2 0.000000e+00 1967/2047 (96%)
EPI177593 A/swine/Hong Kong/NS623/2002 (A/H1N2) segment 1 (PB2) 3325.1 0.000000e+00 1967/2049 (95%)
EPI173586 A/swine/Korea/C13/2008 (A/H5N2) segment 1 (PB2) 3325.1 0.000000e+00 1966/2048 (95%)
EPI106784 A/swine/Korea/PZ72-1/2006 (A/H3N1) segment 1 (PB2) 3325.1 0.000000e+00 1966/2048 (95%)
EPI164123 A/swine/Korea/Hongsong2/2004 (A/H1N2) segment 1 (PB2) 3319.5 0.000000e+00 1964/2047 (95%)
EPI9467 A/Swine/Indiana/P12439/00 (A/H1N2) segment 1 (PB2) 3319.5 0.000000e+00 1965/2048 (95%)
EPI177601 A/swine/Hong Kong/78/2003 (A/H1N2) segment 1 (PB2) 3314.0 0.000000e+00 1965/2049 (95%)
EPI9463 A/Swine/Minnesota/55551/00 (A/H1N2) segment 1 (PB2) 3314.0 0.000000e+00 1964/2048 (95%)
EPI7616 A/Swine/Minnesota/593/99 (A/H3N2) segment 1 (PB2) 3314.0 0.000000e+00 1965/2049 (95%)
EPI7599 A/Swine/Iowa/569/99 (A/H3N2) segment 1 (PB2) 3314.0 0.000000e+00 1965/2049 (95%)
EPI7582 A/Swine/Iowa/533/99 (A/H3N2) segment 1 (PB2) 3314.0 0.000000e+00 1965/2049 (95%)
EPI7565 A/Swine/Nebraska/209/98 (A/H3N2) segment 1 (PB2) 3314.0 0.000000e+00 1965/2049 (95%)
EPI235936 A/equine/North Carolina/152429/2002 (A/H3N8) segment 1 (PB2) 3308.5 0.000000e+00 1962/2047 (95%)
EPI9465 A/Swine/Iowa/930/01 (A/H1N2) segment 1 (PB2) 3308.5 0.000000e+00 1962/2047 (95%)
EPI9461 A/Swine/North Carolina/93523/01 (A/H1N2) segment 1 (PB2) 3308.5 0.000000e+00 1962/2047 (95%)
EPI311388 A/swine/Hong Kong/NS30/2004 (A/H1N2) segment 1 (PB2) 3302.9 0.000000e+00 1964/2050 (95%)
EPI126599 A/swine/Missouri/4296424/2006 (A/H2N3) segment 1 (PB2) 3302.9 0.000000e+00 1960/2046 (95%)
EPI17860 A/duck/NC/91347/01 (A/H1N2) segment 1 (PB2) 3302.9 0.000000e+00 1962/2048 (95%)
EPI164130 A/swine/Korea/PZ14/2006 (A/H1N2) segment 1 (PB2) 3297.4 0.000000e+00 1960/2047 (95%)
EPI164129 A/swine/Korea/PZ7/2006 (A/H1N2) segment 1 (PB2) 3297.4 0.000000e+00 1960/2047 (95%)
EPI126581 A/swine/Missouri/2124514/2006 (A/H2N3) segment 1 (PB2) 3297.4 0.000000e+00 1959/2046 (95%)
EPI164403 A/swine/Korea/JNS06/2004 (A/H3N2) segment 1 (PB2) 3291.8 0.000000e+00 1960/2048 (95%)
EPI164125 A/swine/Korea/JL02/2005 (A/H1N2) segment 1 (PB2) 3291.8 0.000000e+00 1960/2048 (95%)
EPI311372 A/swine/Hong Kong/1578/2003 (A/H1N2) segment 1 (PB2) 3286.3 0.000000e+00 1962/2051 (95%)
EPI164127 A/swine/Korea/Asan04/2006 (A/H1N2) segment 1 (PB2) 3286.3 0.000000e+00 1959/2048 (95%)
EPI9459 A/Swine/North Carolina/98225/01 (A/H1N2) segment 1 (PB2) 3286.3 0.000000e+00 1958/2047 (95%)
EPI7410 A/Swine/Indiana/9K035/99 (A/H1N2) segment 1 (PB2) 3286.3 0.000000e+00 1959/2048 (95%)
EPI273351 A/swine/Heilongjiang/10/2007 (A/H3N2) segment 1 (PB2) 3284.5 0.000000e+00 1957/2047 (95%)
EPI164135 A/swine/Korea/CAS09/2006 (A/H3N2) segment 1 (PB2) 3280.8 0.000000e+00 1958/2048 (95%)
EPI164126 A/swine/Korea/JL04/2005 (A/H1N2) segment 1 (PB2) 3280.8 0.000000e+00 1958/2048 (95%)
EPI164124 A/swine/Korea/JL01/2005 (A/H1N2) segment 1 (PB2) 3280.8 0.000000e+00 1958/2048 (95%)
EPI311428 A/swine/Hong Kong/1111/2004 (A/H1N2) segment 1 (PB2) 3269.7 0.000000e+00 1959/2051 (95%)
EPI292056 A/swine/Iowa/H03HB4/2003 (A/H3N2) segment 1 (PB2) 3269.7 0.000000e+00 1956/2048 (95%)
EPI177633 A/swine/Hong Kong/915/2004 (A/H1N2) segment 1 (PB2) 3269.7 0.000000e+00 1956/2048 (95%)
EPI235268 A/swine/North Carolina/2003 (A/H3N2) segment 1 (PB2) 3264.2 0.000000e+00 1955/2048 (95%)
EPI164134 A/swine/Korea/CAS07/2005 (A/H3N2) segment 1 (PB2) 3264.2 0.000000e+00 1955/2048 (95%)
EPI164133 A/swine/Korea/CAN04/2005 (A/H3N2) segment 1 (PB2) 3264.2 0.000000e+00 1955/2048 (95%)
EPI164137 A/swine/Korea/CY05/2007 (A/H3N2) segment 1 (PB2) 3262.3 0.000000e+00 1955/2048 (95%)
EPI164136 A/swine/Korea/CY04/2007 (A/H3N2) segment 1 (PB2) 3262.3 0.000000e+00 1955/2048 (95%)
EPI164128 A/swine/Korea/PZ4/2006 (A/H1N2) segment 1 (PB2) 3258.6 0.000000e+00 1954/2048 (95%)
EPI164139 A/swine/Korea/CY09/2007 (A/H3N2) segment 1 (PB2) 3256.8 0.000000e+00 1954/2048 (95%)
EPI177641 A/swine/Hong Kong/1562/2005 (A/H1N2) segment 1 (PB2) 3242.0 0.000000e+00 1952/2049 (95%)
EPI164140 A/swine/Korea/CY10/2007 (A/H3N2) segment 1 (PB2) 3242.0 0.000000e+00 1951/2048 (95%)
EPI281306 A/swine/Kentucky/02086/2008 (A/H1N1) segment 1 (PB2) 3236.5 0.000000e+00 1950/2048 (95%)
EPI164138 A/swine/Korea/CY07/2007 (A/H3N2) segment 1 (PB2) 3236.5 0.000000e+00 1950/2048 (95%)
EPI164132 A/swine/Korea/CAS05/2004 (A/H3N2) segment 1 (PB2) 3230.9 0.000000e+00 1948/2047 (95%)
EPI311500 A/swine/Hong Kong/729/2005 (A/H1N2) segment 1 (PB2) 3219.8 0.000000e+00 1949/2050 (95%)
EPI312678 A/swine/Minnesota/226128/2010 (A/H1N1) segment 1 (PB2) 3214.3 0.000000e+00 1848/1901 (97%)
EPI177617 A/swine/Hong Kong/1110/2006 (A/H1N2) segment 1 (PB2) 3208.8 0.000000e+00 1946/2049 (94%)
EPI255733 A/swine/Hong Kong/NS1892/2009 (A/H1N2) segment 1 (PB2) 3203.2 0.000000e+00 1947/2051 (94%)
EPI255725 A/swine/Hong Kong/NS1890/2009 (A/H1N2) segment 1 (PB2) 3203.2 0.000000e+00 1947/2051 (94%)
EPI255717 A/swine/Hong Kong/NS1889/2009 (A/H1N2) segment 1 (PB2) 3203.2 0.000000e+00 1947/2051 (94%)
EPI120026 A/swine/Guangxi/13/2006 (A/H1N2) segment 1 (PB2) 3203.2 0.000000e+00 1946/2050 (94%)
EPI122383 A/chukar/MN/14591-7/1998 (A/H5N2) segment 1 (PB2) 3197.7 0.000000e+00 1945/2050 (94%)
EPI238954 A/mallard/Minnesota/371/1998 (A/H4N2) segment 1 (PB2) 3181.1 0.000000e+00 1944/2052 (94%)
EPI324296 A/swine/Binh Duong/03_14/2010 (A/H3N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI324295 A/swine/Binh Duong/03_13/2010 (A/H3N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI324294 A/swine/Binh Duong/03_10/2010 (A/H3N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI324293 A/swine/Binh Duong/03_09/2010 (A/H3N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI324292 A/swine/Binh Duong/03_08/2010 (A/H3N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI324291 A/swine/Binh Duong/03_06/2010 (A/H3N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI287534 A/swine/Guangdong/1222/2006 (A/H1N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI238927 A/mallard/Minnesota/27/1998 (A/H2N2) segment 1 (PB2) 3175.5 0.000000e+00 1943/2052 (94%)
EPI166060 A/swine/Shanghai/1/2007 (A/H1N2) segment 1 (PB2) 3175.5 0.000000e+00 1940/2049 (94%)
EPI177657 A/swine/Hong Kong/294/2009 (A/H1N2) segment 1 (PB2) 3170.0 0.000000e+00 1941/2051 (94%)
EPI40351 A/green-winged teal/Ohio/178/1999 (A/H6N2) segment 1 (PB2) 3166.3 0.000000e+00 1937/2047 (94%)
EPI255637 A/swine/Hong Kong/2314/2009 (A/H1N2) segment 1 (PB2) 3164.4 0.000000e+00 1937/2047 (94%)
EPI6015 A/Shorebird/Delaware/9/96 (A/H9N2) segment 1 (PB2) 3164.4 0.000000e+00 1938/2049 (94%)
EPI311764 A/swine/Hong Kong/NS252/2009 (A/H1N2) segment 1 (PB2) 3153.4 0.000000e+00 1936/2049 (94%)
EPI321807 A/swine/Hubei/05/2009 (A/H1N2) segment 1 (PB2) 3147.8 0.000000e+00 1935/2049 (94%)
EPI238580 A/mallard/Minnesota/334/1999 (A/H6N5) segment 1 (PB2) 3147.8 0.000000e+00 1934/2048 (94%)
EPI238552 A/mallard/Minnesota/253/1999 (A/H6N5) segment 1 (PB2) 3147.8 0.000000e+00 1934/2048 (94%)
EPI238519 A/mallard/Minnesota/192/1999 (A/H4N6) segment 1 (PB2) 3147.8 0.000000e+00 1934/2048 (94%)
EPI223791 A/Texas/45140902/2009 (A/H1N1 swl) segment 1 (PB2) 3147.8 0.000000e+00 1934/2048 (94%)
EPI183981 A/unknown/New York/1971-40/1998 (A/H1N1) segment 1 (PB2) 3147.8 0.000000e+00 1935/2049 (94%)
EPI316631 A/Wisconsin/629-D01822/2009 (A/H1N1) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI308458 A/Piura/WRAIR1694P/2009 (A/H1N1) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI308314 A/San Diego/WRAIR1658P/2009 (A/H1N1) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI288257 A/Boston/653/2009 (A/H1N1) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI281966 A/Athens/INS322/2009 (A/H1N1) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI266967 A/Mexico City/021/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI259276 A/Athens/INS153/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI252799 A/Texas/JMS370/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI248335 A/Wisconsin/629-D02342/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI246729 A/New York/6213/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI224458 A/Houston/20H/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1932/2047 (94%)
EPI224207 A/Houston/20OS/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1932/2047 (94%)
EPI224039 A/Houston/1H/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1932/2047 (94%)
EPI223783 A/Texas/45093214/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI223384 A/Texas/42091791/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1932/2047 (94%)
EPI221113 A/Nevada/04/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI219193 A/Wisconsin/629-S0254/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)
EPI213704 A/Singapore/ON582/2009 (A/H1N1 swl) segment 1 (PB2) 3142.3 0.000000e+00 1933/2048 (94%)

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First Minnesota case (MN/09/2010) was also hospitalized:

Early identification and investigation of novel influenza A cases is critical to evaluate possible human-to-human transmission. CDC conducts surveillance for human infections with novel influenza A viruses year-round and carries out extensive epidemiologic investigations on each case. During the 2009-10 season, in addition to the pandemic strain virus infections, three cases of human infection with novel influenza A viruses were identified and then characterized at CDC. These three cases, identified in Kansas, Iowa, and Minnesota, were isolated cases of human infections with contemporary North American swine-lineage influenza A (H3N2) viruses currently circulating in swine herds. No additional human cases were linked to these three patients. Although the Minnesota patient reported visiting a live animal market in the days preceding illness onset (May 8, 2010), only the Kansas patient specifically reported contact with pigs in the week preceding symptom onset (July 28, 2009). The Iowa patient had onset of symptoms in September 2009. The Kansas and Iowa patients did not require hospitalization; the Minnesota patient was hospitalized, and recovered fully.
http://jama.ama-assn.org/content/304/9/957.full

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In summary, of the 8 trH3N2 confirmed cases, 3 have been hospitalized (MN/09/2010, WI/12/2010, MN/11/2010) and all recovered.

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