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PostPosted: Sat Aug 06, 2011 8:30 am 
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This week the CDC released sequences from a case in Minnesota A/Minnesota/11/2010) which was used to make a vaccine target. This was followed by yesterday's MMWR acknowledging a second trH3N2 case reported in 2011. This announcement was almost certainly linked to a familial cluster and isolation of trH3n2 from a family member.

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PostPosted: Sat Aug 06, 2011 8:34 am 
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Earlier report on cluster

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6021a5_w

Five cases of human infection with a novel influenza A virus were reported during the 2010--11 influenza season from three states. All five cases were infected with swine-origin influenza A (H3N2) viruses. Two cases occurred in September (Pennsylvania and Wisconsin), one case in October (Pennsylvania), and two cases in November (Minnesota). Two of the five cases occurred in adults, and three occurred in children. Two of the five cases were hospitalized; all five have recovered fully from their illness. The two cases in Pennsylvania were not related. The cases in Wisconsin and Pennsylvania had direct contact with swine or lived in areas close to swine farms. The two cases from Minnesota occurred in a father (index case) and child. The father had a nasopharyngeal swab positive for swine-origin influenza A (H3N2) virus and had direct swine exposure 6 days before illness onset. The child, whose infection with influenza A (H3N2) virus was confirmed several weeks later by serologic testing, did not have direct swine exposure, and most likely acquired infection from close contact with her father. Other persons in the same household also had ILI during the same period, but serologic results were either negative or inconclusive.

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PostPosted: Sat Aug 06, 2011 8:38 am 
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Vaccine target, A/Minnesota/11/2011 is from father (31M) collected Nov 26, 2011. Two variations have been created and sequences released this week

A/Minnesota/11/2010 X-203A EPI_ISL_94334 H3N2 EX --- --- --- 1701 --- 1410 --- --- --- --- Garten, Rebecca 2010
A/Minnesota/11/2010 X-203 EPI_ISL_94333 H3N2 EX --- --- --- 1701 --- 1410 --- --- --- --- Garten, Rebecca 2010

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PostPosted: Sat Aug 06, 2011 8:50 am 
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Three cases of human infection with a novel influenza A virus were reported during November and December, one each from Wisconsin, Pennsylvania, and Minnesota. Onset of the illnesses occurred in September, October, and November, respectively. All three patients were infected with swine-origin influenza A (H3N2) viruses. Two of the three cases occurred in adults, and the third occurred in a child. Two of the three patients were hospitalized; all three have fully recovered from their illness. The three cases are not related, and influenza viruses recovered from each of these cases were similar but not identical, indicating that they did not come from a common source. All three patients had either contact with swine or lived in areas close to swine farms. No evidence of human-to-human transmission of these viruses was identified in the first two cases, and investigation of the third case is ongoing.

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5950a4.htm

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PostPosted: Sat Aug 06, 2011 9:08 am 
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MN/11/2011 has an HA closely related to WI/12/2010, PA/40/2010, and MN09/2010. However NA is distinct and distantly related to PA/14/2010. Most other genes are close to WI/12 and PA/40.

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PostPosted: Sat Aug 06, 2011 9:56 am 
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Commentary

http://www.recombinomics.com/News/08061 ... r_VAX.html

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PostPosted: Sat Aug 06, 2011 10:30 am 
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The cluster and linkage to the H3N2 pandemic vaccine will be discussed Tuesday, August 9 at 11 PM EST on rense

http://www.renseradio.com/listenlive.htm

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PostPosted: Sat Aug 06, 2011 10:34 am 
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Initail report on index case

http://www.cdc.gov/media/haveyouheard/2010.html#1217

Report of Human Infection with Swine Origin Influenza A (H3N2)

The December 17, 2010 FluView reported one human infection with swine origin influenza A (H3N2) virus in the state of Minnesota as part of U.S. surveillance and reporting of novel influenza A viruses. Test samples from one patient in Minnesota were confirmed at CDC as positive for swine origin triple-reassortant (tr) H3N2 influenza viruses—viruses that normally infect pigs. Although human infection with swine influenza viruses is rare, it can occur. This is most likely to occur when people are in close proximity to infected pigs, such as in pig barns and at livestock exhibits housing pigs at fairs. The patient in Minnesota with confirmed trH3N2 infection had exposure to pigs prior to illness onset. There is no documented human-to-human transmission of this virus or any evidence of community transmission at this time. An investigation of this case is ongoing. Cases of human infection with swine influenza viruses underscore the importance of ongoing human and animal influenza surveillance.

This case of human infection with swine origin influenza virus (SOIV) brings the total number of human infections with swine origin influenza viruses reported to CDC since 2005 to 19. Previously, five of these reports had been swine origin A (H3N2) viruses. The most recent Minnesota case brings the number of reports swine origin A (H3N2) infections in humans in the United States to six. Human infections with swine origin H3N2 virus infections have also been reported from Pennsylvania and Wisconsin in October and November 2010, Minnesota in May 2010, Iowa in September 2009, and Kansas in August 2009.

Swine influenza (swine flu) is a respiratory disease of pigs caused by type A influenza viruses that regularly cause outbreaks of influenza in pigs. Swine flu viruses can result in high illness rates in pig herds, but generally cause few deaths in pigs. Swine influenza viruses can circulate among pigs throughout the year, but most outbreaks occur during the late fall and winter months, similar to outbreaks in humans. There are four main influenza type A virus subtypes that have been isolated in pigs: H1N1, H1N2, H3N2 and H3N1. Most flu viruses circulating in pigs are referred to as "triple-reassortant" viruses because these flu viruses contain genes from human, swine and avian influenza viruses.

It's important to note that swine influenza viruses are not transmitted to humans by food. You cannot get swine influenza from eating pork or pork products. Eating properly handled and cooked pork and pork products is safe.

In 2007 human infections with novel influenza viruses such as swine influenza became nationally notifiable. Previously, CDC has received reports of approximately one human infection with a swine influenza virus every one to two years, but in the past few years, about four cases have been reported per year.

These trH3N2 viruses are different from the 2009 H1N1 virus that has been circulating in the United States since late April 2009. They are also different from human seasonal influenza A (H3N2) viruses that typically circulate among people during the flu season. Swine trH3N2 viruses commonly circulate in pigs in North America, but human infections are rarely detected. These viruses are different from the swine classical H1N1 or swine trH1N1 influenza viruses that also circulate in pigs in North America because they have H3N2 surface antigens. TrH3N2 viruses first were detected in North American swine herds in the late 1990s. The H3 and N2 genes originated from human seasonal H3N2 influenza viruses that circulated globally among humans in the late 1990s. However, currently circulating swine H3 and N2 genes are now notably different from human influenza virus H3 and N2 genes.

Although the vast majority of instances of human infection with animal influenza viruses do not result in human-to-human transmission, each case should be fully investigated to be sure that such viruses are not spreading among humans and to limit further exposure of humans to infected animals if infected animals are identified. Surveillance for both seasonal and novel influenza viruses is conducted by CDC and its state and local health partners year round.

For more information about swine influenza, visit http://www.cdc.gov/flu/swineflu/

Weekly U.S. surveillance updates are published in FluView and posted at http://www.cdc.gov/flu/weekly/fluactivitysurv.htm

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PostPosted: Sat Aug 06, 2011 10:39 am 
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Parallel H1N1 Pandemics in 2010?
Recombinomics Commentary 03:50
July 7, 2010


An H1N1 influenza A virus, A/swine/Ohio/24366/07, was isolated from pigs in an Ohio county fair. Twenty-six people who came in contact with the infected pigs developed respiratory disease and two of these people were laboratory confirmed as H1N1 by the Centers for Disease Control and Prevention (CDC). The A/swine/Ohio/24366/07 virus we isolated from swine was shown at the CDC to have 100% identical genome sequence to the human virus associated with the county fair.

The above comments describe a swine H1N1 isolate from pigs at a 2007 Huron county fair in Ohio. In 2009 the sequences from the two confirmed cases, an exhibitor (10F) and her father (36M) were released. The two human HA sequences, A/Ohio/01/2007 and A/Ohio/02/2007, were identical to each other and from a triple reassortant with a human PB1, avian PB2 and PA and 5 North American swine sequences for the other five gene segments.

http://www.recombinomics.com/News/07071001/pH1N1x2.html

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PostPosted: Sat Aug 06, 2011 10:43 am 
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niman wrote:
Parallel H1N1 Pandemics in 2010?
Recombinomics Commentary 03:50
July 7, 2010

An H1N1 influenza A virus, A/swine/Ohio/24366/07, was isolated from pigs in an Ohio county fair. Twenty-six people who came in contact with the infected pigs developed respiratory disease and two of these people were laboratory confirmed as H1N1 by the Centers for Disease Control and Prevention (CDC). The A/swine/Ohio/24366/07 virus we isolated from swine was shown at the CDC to have 100% identical genome sequence to the human virus associated with the county fair.

Many of the interal genes in MN/11/2010 are closely related to those from human isolates from the above Huron County fair in 2007. This cluster was the largest reported swine flu outbreak since the Fox Dix outbreak in 1976. These internal genes are present in tha vast majority of trH3N2 human isolates. In the US, all reported trH3N2 cases followed the H1N1 pademic in 2009.

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