Rhiza Labs FluTracker Forum

The week 30 MMWR reports a new novel influenza case

Novel influenza A infection virus *** - 2 0 4 43,774 2 4 NN
http://wonder.cdc.gov/mmwr/mmwr_reps.as ... wr_table=1

This is likely another trH3N2 case in 2011. More detail will be released later today when tomorrow's week 30 MMWR report is released.

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*** Please refer to the MMWR publication for weekly updates to the footnote for this condition.
Online version of report is usually available around noon on Thursdays.

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Updated report will appear here

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6030md_w

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Commentary

http://www.recombinomics.com/News/08041 ... MWR30.html

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Week 29 report


Novel influenza A virus infections***


---


1


0


4


43,774


2


4


NN
*** CDC discontinued reporting of individual confirmed and probable cases of 2009 pandemic influenza A (H1N1) virus infections on July 24, 2009. During 2009, four cases of human infection with novel influenza A viruses, different from the 2009 pandemic influenza A (H1N1) strain, were reported to CDC. The four cases of novel influenza A virus infection reported to CDC during 2010, and the one case reported during 2011, were identified as swine influenza A (H3N2) virus and are unrelated to the 2009 pandemic influenza A (H1N1) virus. Total case counts for 2009 were provided by the Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD).

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6029md_w

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Sequences from six of the nine previously reported cases were released. It is likely that the 3 unreleased cases in 2009 were linked to the fair in Kansas, since the released sequence was from a young adult (KS/13/09), while media reports described a child.

This cluster was followed by the first case from MN (MN/09/10). The first case in PA (PA/40/10) was not reported until 2011. It was closely related to the WI case (WI/12/10) and the second MN case (MN/11/10). A second PA case (PA14/10) was reported with WI/12 so the CDC could claim they were not closely related.

Thus, there are three very closely related sequences (PA/40, WI/12, and MN11). MN is the most recent and the target of the H3N2 pandemic vaccine.

EPI244297 A/Kansas/13/2009
EPI291838 A/Minnesota/09/2010
EPI312980 A/Pennsylvania/40/2010
EPI291893 A/Wisconsin/12/2010
EPI291865 A/Pennsylvania/14/2010
EPI293965 A/Minnesota/11/2010
EPI328898 A/Minnesota/11/2010 X-203
EPI328900 A/Minnesota/11/2010 X-203A

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There us also a partial sequences from a 12M case in Iowa in 2009

EPI291813 A/Iowa/16/2009

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The page on swine in humans just cites 7 cases, which would match the 7 public sequences, indicating the 9 cases in the MMWR include two additional cases from 2009 (which could be trH3N2 or trH1n1).

http://www.cdc.gov/flu/swineflu/soiv_cases.htm

Reported Human Infections with Swine Origin Influenza Viruses (SOIV) in the United States since 2005

As of January 25, 2011, 20 cases of human infection with swine origin influenza viruses (SOIV) have been reported in the United States. These are viruses that normally infect pigs. Like human influenza viruses, there are different subtypes and strains of swine origin influenza viruses. The main swine viruses circulating in U.S. pigs in recent years are swine triple reassortant (tr) H1N1 influenza virus, trH3N2 virus and trH1N2 virus. Of the 20 human cases reported since 2005, 12 have been trH1N1 viruses, seven have been trH3N2 viruses and one has been a trH1N2 virus. All 20 persons infected with swine viruses recovered from their illness. Thirteen cases occurred in children (persons younger than 19) and 7 cases occurred in adults. In 16 cases, direct or indirect exposure to swine prior to onset of illness has been identified. Although no person-to-person transmission of swine influenza viruses has been laboratory confirmed in the investigation of these cases to date, some cases reported only exposure to ill persons and no exposure to live pigs. Thus, limited person-to-person is likely to have occurred.

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*** CDC discontinued reporting of individual confirmed and probable cases of 2009 pandemic influenza A (H1N1) virus infections on July 24, 2009. During 2009, four cases of human infection with novel influenza A viruses, different from the 2009 pandemic influenza A (H1N1) strain, were reported to CDC. The four cases of novel influenza A virus infection reported to CDC during 2010, and the two cases reported during 2011, were identified as swine influenza A (H3N2) virus and are unrelated to the 2009 pandemic influenza A (H1N1) virus. Total case counts for 2009 were provided by the Influenza Division, National Center for Immunization and Respiratory Diseases (NCIRD).

http://www.cdc.gov/mmwr/PDF/wk/mm6030.pdf

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The above comments confirm that the new novel case reported in the week 30 MMWR is trH3N2 (pandemic H3N2).

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