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PostPosted: Mon Jun 13, 2011 9:04 am 
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EPI247402 A/North Carolina/03/2010 2010-01-20 22F
EPI252143 A/Minnesota/02/2010 2010-02-17 38M
EPI250023 A/North Carolina/05/2010 2010-02-24 25M

Closely related sequences with S246N signaling tranmission in the United States.

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PostPosted: Mon Jun 13, 2011 9:10 am 
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EPI309633 A/Croatia/18576-1/2010 2010-12-23
EPI309685 A/Slovenia/234/2011 2011-01-13 8F

Closely related sequences with S246N signaling transmission in Europe.

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PostPosted: Mon Jun 13, 2011 9:14 am 
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cpg wrote:
Dingo just read this and make up your own mind. For now both drugs are good. Of course this may change but we are not taking about what might happen but what is happening now.

If Relenza becomes non-effective you will be the first to know. Just remember H274 doesnt effect Relenza.


''Patients who receive the recommended dosages of oseltamivir and zanamivir would easily have high enough systemic levels of the drugs to still be effective against the S247N variant, "and therefore the variant is unlikely to be clinically resistant," the report states.''


http://www.cidrap.umn.edu/cidrap/conten ... esist.html



'SINGAPORE--A new H1N1 virus strain discovered by collaborating scientists in Singapore last December may yet mutate dangerously.'

'It is already mildly resistant to common drugs such as Tamiflu and Relenza. For now, a full dose of these drugs is still effective against the new strain'

http://www.chinapost.com.tw/life/scienc ... s-warn.htm

You remain a clueless clown. Please post your propaganda on a Biota board. S246N is a MAJOR problems (with 6 or 3 fold reductions in effectiveness for Tamiflu and Relenza, respectively).

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PostPosted: Mon Jun 13, 2011 10:46 am 
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cpg wrote:
Dingo just read this and make up your own mind. For now both drugs are good. Of course this may change but we are not taking about what might happen but what is happening now.

If Relenza becomes non-effective you will be the first to know. Just remember H274 doesnt effect Relenza.


''Patients who receive the recommended dosages of oseltamivir and zanamivir would easily have high enough systemic levels of the drugs to still be effective against the S247N variant, "and therefore the variant is unlikely to be clinically resistant," the report states.''


http://www.cidrap.umn.edu/cidrap/conten ... esist.html



'SINGAPORE--A new H1N1 virus strain discovered by collaborating scientists in Singapore last December may yet mutate dangerously.'

'It is already mildly resistant to common drugs such as Tamiflu and Relenza. For now, a full dose of these drugs is still effective against the new strain'

http://www.chinapost.com.tw/life/scienc ... s-warn.htm
The media reports are based on a comment in Eurosurveillance citing a 1999 paper written BEFORE the clinical problems with H5N1, seasonal H1N1, and pandemic H1N1 linked to dosing differences of TWO fold.

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PostPosted: Mon Jun 13, 2011 11:16 am 
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Commentary

http://www.recombinomics.com/News/06131 ... nical.html

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PostPosted: Mon Jun 13, 2011 3:25 pm 
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Commentary

http://www.recombinomics.com/News/06131 ... sters.html

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PostPosted: Mon Jun 13, 2011 8:34 pm 
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niman wrote:


Now that's funny and maybe Niman will get it right one day. There is always a concern about resistance like there is a concern a meteor can hit someone on the head.I believe we are traveling through a asteroid field at the moment.

You write a article linking s246 with i222 resistance based on absolutely not one shread of scientific evidence connecting the two. No wonder you have been banned from every scientific blog on the planet except your own.


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PostPosted: Tue Jun 14, 2011 12:32 am 
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cpg wrote:
niman wrote:


Now that's funny and maybe Niman will get it right one day. There is always a concern about resistance like there is a concern a meteor can hit someone on the head.I believe we are traveling through a asteroid field at the moment.

You write a article linking s246 with i222 resistance based on absolutely not one shread of scientific evidence connecting the two. No wonder you have been banned from every scientific blog on the planet except your own.

You remain a clown. The eurosurveillance article linked them. Only Biota shareholders discount the link. Your lack of understanding of resistance or rationale thought is profound.

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PostPosted: Tue Jun 14, 2011 12:44 am 
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niman wrote:
cpg wrote:
niman wrote:


Now that's funny and maybe Niman will get it right one day. There is always a concern about resistance like there is a concern a meteor can hit someone on the head.I believe we are traveling through a asteroid field at the moment.

You write a article linking s246 with i222 resistance based on absolutely not one shread of scientific evidence connecting the two. No wonder you have been banned from every scientific blog on the planet except your own.

You remain a clown. The eurosurveillance article linked them. Only Biota shareholders discount the link. Your lack of understanding of resistance or rationale thought is profound.



That was a broad sweeping comment to be on the lookout for higher resistance profiles due to s246. No where did they link it to the i222 mutation. There are many mutations and new ones will come.You extrapolate information to suit your own agenda. Otherwise known as making it up as you go.

One minute you discredit eurosurveillance the next you are using there comments and twisting them to suit.


Last edited by cpg on Tue Jun 14, 2011 12:47 am, edited 1 time in total.

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PostPosted: Tue Jun 14, 2011 12:46 am 
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Posts: 27261
Location: Pittsburgh, PA USA
cpg wrote:
niman wrote:
cpg wrote:
Now that's funny and maybe Niman will get it right one day. There is always a concern about resistance like there is a concern a meteor can hit someone on the head.I believe we are traveling through a asteroid field at the moment.

You write a article linking s246 with i222 resistance based on absolutely not one shread of scientific evidence connecting the two. No wonder you have been banned from every scientific blog on the planet except your own.

You remain a clown. The eurosurveillance article linked them. Only Biota shareholders discount the link. Your lack of understanding of resistance or rationale thought is profound.



That was a broad sweeping comment to be on the lookout for higher resistance profiles due to s246. No where did they link it to the i222 mutation. There are many mutations and new ones will come.You extrapolate information to suit your own agenda. Otherwise known as making it up as you go.

The specifically cited 246 linked to 222, as would anyone disucssing Relenza resistance.

Given that a number of studies have recently reported I223 mutations conferring NAI resistance in influenza A(H1N1)2009 strains [3,4,9,10], and that data from the United Kingdom show an increased frequency of H275Y mutants in community samples [2], the likelihood of mutation combinations S247N+I223X and S247N+H275Y is considerably increased if the S247N influenza A(H1N1)2009 variant continues to spread.

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