Rhiza Labs FluTracker Forum

This is all about evolution and the rate of change. There is now more immunity to H1N1 due to prior infections or vaccinations, which puts more selective pressure on the emergence of new clades. This led to the dominance of the S188T sub-clade and the emergence of Chihuahua. This battle leads to more swapping of genetic information and the reassortment demonstrates the swapping between the co-circulating sub-clades. However, the H274Y in Delaware and Maryland is jumping onto multiple sub-clades, so H274Y will be on any one that dominates. Thus, like 2008, Tamiflu resistance will go to 100% in pandemic H1N1, like in 2008 when it went to 100% in seasonal H1N1.

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Thanks again.

From what you know, is any of the H1N1 currently circulating close enough to what was around in 2009/2010 so that previous infection/and or vaxing will help at all?

I'm personally interested due to having had it at least once (and it was horrible) and also for others I inform.

Can someone please advise me ... I have not seen any mention that this pandemic alert has been lifted. Did I miss anything, or is it still in effect? Thanks! -k

This pandemic will follow the path of 2009. Most activity is currently in southern hemisphere.

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Thanks Dr. Niman. As I thought. And so, 'officially', the alert has not been lifted by WHO. Thanks! -k

CDC is testing a pandemic trH3N2 vaccine

http://www.recombinomics.com/News/08031 ... ccine.html

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CDC PLOS paper on D225G acknowledges enhance replication in human bronchial epithelial cells

http://www.plosone.org/article/info%3Ad ... ne.0025091

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Utter nonsense

http://www.plosone.org/article/info%3Ad ... ne.0025091

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Paper on D225N in US and Ecuador published

Severe disease reported in 3 patients with mutated H1N1
Two cases of pandemic 2009 H1N1 flu with a mutation in the virus's hemagglutinin (HA) earlier this year indicate the mutation may be associated with more severe disease, according to a study in the Journal of Clinical Virology. US researchers reported on two patients from Ecuador and one from Washington, DC, who were infected by a 2009 H1N1 variant with a mutation within the primary HA receptor-binding site. All required mechanical ventilation, and one died. The D222N mutation was confirmed in two of the patients, but all the isolates were found to be from a subclade phylogenetically homologous with strains associated with recent deaths in Chihuahua, Mexico. The authors conclude, "Previously, enhanced virulence associated with the change, D222G, has been clinically linked to severe morbidity and mortality. Initial observations of the prevalence of a novel sub-clade of strains in the Americas suggest that viruses with a re-emergent D222N mutation may too correlate with severe clinical manifestations."
Oct 28 J Clin Virol abstract
http://www.sciencedirect.com/science/ar ... 3211003672

http://www.cidrap.umn.edu/cidrap/conten ... uscan.html

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