Rhiza Labs FluTracker Forum

Demographics of the four most recent cases:

#11: 44F, New Castle County

#12: 27M, Sussex County

#13: 4M, Sussex County

#14: 40M, Sussex County

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Sequences with S188T and A189T (known Tamiflu resistance with asterisks)

EPI316342 A/Delaware/06/2011*
EPI316329 A/Alabama/02/2011
EPI316264 A/HIROSHIMA/45/2011
EPI310151 A/Virginia/02/2011
EPI310148 A/Virginia/01/2011
EPI310005 A/Michigan/02/2011
EPI309914 A/Iowa/04/2011
EPI309898 A/Illinois/02/2011
EPI309870 A/Delaware/07/2011*
EPI309857 A/Delaware/04/2011*
EPI309657 A/Georgia/51/2011
EPI308908 A/North Carolina/AF21793/2010
EPI302358 A/PERTH/219/2010
EPI301443 A/Luxembourg/521/2010
EPI294306 A/PERTH/219/2010

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Commentary

http://www.recombinomics.com/News/05111 ... DE_MD.html

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an article linked under the CIDRAP report lists the number of samples that Delaware tested, from which 14 were found to be antiviral-resistant flu cases.

http://www.delawareonline.com/article/2 ... text|Local

Antiviral-resistant flu
Total number of cases in Del. rises to 14

A form of influenza that cannot be successfully treated with common medicines was identified in eight more people in Delaware, public health officials reported Tuesday.

Those new discoveries -- which included four new cases identified Tuesday afternoon -- bring the total number of antiviral-resistant flu cases during the 2010-2011 flu season in Delaware to 14. The state has never experienced that many cases of antiviral-resistant flu. ........ snipped

Here's the May 11th CIDRAP version:

http://www.cidrap.umn.edu//cidrap/conte ... sscan.html

Delaware reports more Tamiflu-resistant flu cases

Delaware's health department recently reported eight more infections with 2009 H1N1 influenza viruses that are resistant to oseltamivir (Tamiflu), pushing the state's total this season to 14. In a May 9 statement, the Delaware Department of Health and Social Services (DDHSS) reported four of those cases, including in a 45-year-old woman from Sussex County who died. Today Jennifer Wooleyhand, a spokeswoman for the DDHSS, told CIDRAP News that the state had identified four additional cases, of which three are from Sussex County: in a 27-year-old man, a 4-year-old boy, and a 40-year-old man. The fourth new case is in a 44-year-old woman from New Castle County. She said the newest cases have no known relationships, except for living in the same county. (Delaware has only three counties.) The US Centers for Disease Control and Prevention (CDC) has asked Delaware to increase its antiviral-resistance testing, and the DDHSS said the findings will help the CDC revise its recommendations for next year, if needed. Nationally, the CDC's own routine testing of flu isolates since Oct 1 has found 32 2009 H1N1 samples and 2 H3N2 samples that were resistant to oseltamivir, according to its latest update on May 6. Jeff Diamond, a spokesman with the CDC, said the agency asked Delaware to participate in a closer study of oseltamivir-resistant flu viruses, because it has ZIP code and demographic information to include with the samples, the News Journal, based in Wilmington, reported today.

But the 4 sequences at GISAIDwere collected in early February, BEFORE the submissions were increased.

The detection of H274Y in FEBRUARY CAUSED the increase in collections after March.

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Delaware did not issue a press reelase on the four most recent cases because they expect MORE examples. 14 is only the beginning of confirmed Delaware H1N1 sequences with H274Y.

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Region III ILI

http://isdsdistribute.org/linecharts/56.html

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Website has state charts for PA, MD, VA which don't show spike, suggesting increase in region is focused in Delaware (or DC or WV).

http://isdsdistribute.org/

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