Rhiza Labs FluTracker Forum

You don't understand evolution at the BASIC level and your lack of understanding of influenza evolution is PROFOUND. The VAST majority of changes linked to immunological escape are due to changes in HA and NA, and the sequences of HA and NA in Chihuahua are published and have NO reassortment.
Please stop posting utter nonsense here.
Go back to your babble boards and parallel universe, where someone will believe your nonsense.

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www.twitter.com/hniman

I have amino acid changes K163N,S179N,A203T,S220T
(substract 14 to get your enumeration)

S220T is a Cancun-mutation, now in >99% of all mexflu viruses

S179N and A203T were seen in USA 2011 without much consequences

shall it be that one K163N ??


D225G happens on multiple backgrounds and is not
specific to this substrain (most samples of which don't have it)

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no patents on genes, publish the GISAID sequences !

most pandemics or new outbreaks or new waves are linked to reassortment,
which is a more dramatical change than just point-mutation
and may change the properties of a virus very much, i.e. transmissiability

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no patents on genes, publish the GISAID sequences !

I use H3 numbering (which is used in most discussions of receptor binding domain changes). D225N is quite rare and not heavily concentrated on most sub-clade, but it is on the Chihuahua sub-clade. Evolution and selection involve combinations of changes.
You have no data on "consequences" in 2011 because you ignore the sequences at GISAID.

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www.twitter.com/hniman

Reading 101. D225N is not D225G (and Chihuahua sequences were direct and from the UPPER respiratory tract - D225N in pandemic H1N1 is at higher concentrations in lower respiratory tract).
You fail to understand the data at the MOST BASIC level, including the most relevant change.

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www.twitter.com/hniman

Please. You remain clueless. The Chihuahua sub-clade is emerging as a new wave with NO reassortment. Your lack of understaing of influenza evolution was a likely factor in your absurd posts two years ago when you claimed a 20% chance that the 2009 pandemic wan't a pandemic. You were clueless then and are clueless now.

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www.twitter.com/hniman

I didn't say anything about S206T (your S220T), but have said quite a bit about D225N, so you talk about an irrelevant change and ignore the most fundamental change, D225N, which improves TRANSMISSION and is found at detectable levels in the UPPER respiratory tract in severe/fatal cases.

You either miss or misrepresent the most fundament change in the Chihuahua sub-clade. Anyone paying attention to the Chihuahua sub-clade has noted the high frequency of D225N in severe/fatal cases (and the frequency is even higher in withheld sequences). It has been mentioned in MULTIPLE commentaries (just google recombinomics and D225N).
You remain clueless, at best.

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www.twitter.com/hniman

> D225N, which improves TRANSMISSION

who else says this ? give a source

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no patents on genes, publish the GISAID sequences !

> D225N is not D225G (and Chihuahua sequences were direct and from
> the UPPER respiratory tract - D225N in pandemic H1N1 is at higher
> concentrations in lower respiratory tract).

yes, I thought you meant D225G. No D225G nor D225N at genbank
in Chi2

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no patents on genes, publish the GISAID sequences !

Please. D225N is on SEASONAL H3N2 and was involved in the fixing of adamantane resistance (S31N). This data is old and quite well known to those in the field (just google D225N and S193F).
You spend too much time on babble boards and in a parallel universe.
You lack of understanding of receptor binding domain changes is PROFOUND.

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www.twitter.com/hniman