Rhiza Labs FluTracker Forum

The place to discuss the flu
It is currently Wed May 22, 2013 7:05 am

All times are UTC - 5 hours [ DST ]




Post new topic Reply to topic  [ 91 posts ]  Go to page Previous  1, 2, 3, 4, 5, 6, 7 ... 10  Next
Author Message
PostPosted: Fri Jan 07, 2011 4:30 am 
Offline

Joined: Wed Oct 07, 2009 5:01 am
Posts: 15
Location: USA
Fatal Divergency on 4 UK Zoonotic Sequences

_________________
http://genewurx.com/
Independent Primary Research on Viral Genetics and the
Host-Pathogen Immune Dynamics of Zoonotic Influenza Reservoirs


Last edited by NS1 on Fri Jan 07, 2011 6:47 am, edited 1 time in total.

Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 5:18 am 
Offline

Joined: Sat Jan 30, 2010 2:44 am
Posts: 887
NS1 wrote:
[
The common ground among these sequences and those in the database on either side of them temporally, especially Iran, is the high quantity of polymorphisms that are novel or rare to pH1N1 and that also appear in zoonotic reservoirs, particularly H3N8, H5N1 and H7N7.

Even small genetic adjustments from animal vectors into human infections, especially H3N8, may create variant behaviour. This potential era of zoonotic sub-segment spillover merits as much investigation for severity (in combination) as does the recognised 225G.


Do we have much sequences or data from 1957 or 1968? I'm wondering if the acquisition of these zoonotic changes is a recent thing, or happened with past pandemics and explains the leap in virulence?


Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 5:42 am 
Offline
User avatar

Joined: Tue Sep 01, 2009 11:54 pm
Posts: 1775
Location: germany
the latest report from week 52 shows a decline of ILI in the UK !

http://www.hpa.org.uk/web/HPAwebFile/HP ... 4475036543

_________________
no patents on genes, publish the GISAID sequences !


Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 6:18 am 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27367
Location: Pittsburgh, PA USA
gsgs wrote:
the latest report from week 52 shows a decline of ILI in the UK !

http://www.hpa.org.uk/web/HPAwebFile/HP ... 4475036543

Holidays always drop numbers at end of year.

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 6:30 am 
Offline

Joined: Sun Sep 26, 2010 9:47 am
Posts: 324
After children go back to school, numbers will increase !!!


Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 6:55 am 
Offline
User avatar

Joined: Tue Sep 01, 2009 11:54 pm
Posts: 1775
Location: germany
not always. Not last year.

Yes, it went up again in week 1 in some of the previous years
but the level was still smaller than in week 51

the positives rate loos also good.
At least not much increasing, near the peak,
depending on the scheme

page 34ff


combined : page 44 dotted line
almost stable

_________________
no patents on genes, publish the GISAID sequences !


Last edited by gsgs on Fri Jan 07, 2011 7:11 am, edited 4 times in total.

Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 6:58 am 
Offline

Joined: Wed Oct 07, 2009 5:01 am
Posts: 15
Location: USA
Dingo wrote:
NS1 wrote:
[
The common ground among these sequences and those in the database on either side of them temporally, especially Iran, is the high quantity of polymorphisms that are novel or rare to pH1N1 and that also appear in zoonotic reservoirs, particularly H3N8, H5N1 and H7N7.

Even small genetic adjustments from animal vectors into human infections, especially H3N8, may create variant behaviour. This potential era of zoonotic sub-segment spillover merits as much investigation for severity (in combination) as does the recognised 225G.


Do we have much sequences or data from 1957 or 1968? I'm wondering if the acquisition of these zoonotic changes is a recent thing, or happened with past pandemics and explains the leap in virulence?


Influenza Flux is always at work. We estimate that the ebb and flow is much more active during a pandemic era prior to the Omega form being reached.

JKT recently did some newspaper perusal from the late 1800's to early 1900's and found epizootics reported. Mike Coston profiled that piece well on Avian Flu Diary. The relationship of animal breakouts and human breakouts is not completely correlated temporally, using only the data available from newspapers.

Dr. Niman will be a more astute professor on 1957 and 1968 than we can be.

_________________
http://genewurx.com/
Independent Primary Research on Viral Genetics and the
Host-Pathogen Immune Dynamics of Zoonotic Influenza Reservoirs


Last edited by NS1 on Fri Jan 07, 2011 12:12 pm, edited 2 times in total.

Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 7:18 am 
Offline

Joined: Sat Jan 30, 2010 2:44 am
Posts: 887
NS1 wrote:
Dingo wrote:
Do we have much sequences or data from 1957 or 1968? I'm wondering if the acquisition of these zoonotic changes is a recent thing, or happened with past pandemics and explains the leap in virulence?


Influenza Flux is always at work. We estimate that the ebb and flow is much more active during a pandemic era prior to the Omega form being reached.

JKT recently did some newspaper perusal from the late 1800's to early 1900's and found epizootics reported. The relationship of animal breakouts and human breakouts is not completely correlated temporally, using only the data available from newspapers.

Dr. Niman will be a more astute professor on 1957 and 1968 that we can be.


Thanks. i was wondering if changes to animal husbandry since say 1957 may have accelerated this?


Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 7:24 am 
Offline

Joined: Sat Jan 30, 2010 2:44 am
Posts: 887
niman wrote:
Image


Interesting that most fatal and severe cases did not have 225G or E


Top
 Profile  
 
PostPosted: Fri Jan 07, 2011 7:30 am 
Offline

Joined: Wed Oct 07, 2009 5:01 am
Posts: 15
Location: USA
Dingo wrote:
NS1 wrote:
Dingo wrote:
Do we have much sequences or data from 1957 or 1968? I'm wondering if the acquisition of these zoonotic changes is a recent thing, or happened with past pandemics and explains the leap in virulence?


Influenza Flux is always at work. We estimate that the ebb and flow is much more active during a pandemic era prior to the Omega form being reached.

JKT recently did some newspaper perusal from the late 1800's to early 1900's and found epizootics reported. The relationship of animal breakouts and human breakouts is not completely correlated temporally, using only the data available from newspapers.

Dr. Niman will be a more astute professor on 1957 and 1968 that we can be.


Thanks. i was wondering if changes to animal husbandry since say 1957 may have accelerated this?


Yes. Crowding, unnatural environment, unnatural feed and the prophylactic veterinary process. All factors.

The results, especially in large scale poultry / swine operations, are evident (H1N1, H5N1, H9N2).

_________________
http://genewurx.com/
Independent Primary Research on Viral Genetics and the
Host-Pathogen Immune Dynamics of Zoonotic Influenza Reservoirs


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 91 posts ]  Go to page Previous  1, 2, 3, 4, 5, 6, 7 ... 10  Next

All times are UTC - 5 hours [ DST ]


Who is online

Users browsing this forum: niman and 34 guests


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Search for:
Jump to:  
Powered by phpBB® Forum Software © phpBB Group