Dingo wrote:
Three questions please:
1. Is E627K found in non-pandemic flus in pigs? If so, they could be a reassortment vessel for this to spread widely in humans.
2. From my reading here and Dr Niman's commentaries, I recall that this mutation was regarded as the last and most dangerous missing part of the jigsaw for pandemic swine flu to really take off (ie be both highly contagious and deadly) - is this correct?
3. From the commentary, it's checked for in gene sequences, but has only been found spontaneously in two places previously?
Re #3, I suppose this is little comfort. Every story about a significant mutation starts with the first one or cluster found, I suppose.
There are swine PB2 sequencs with E627K, but thye would be easily distiguished from the avian PB2 in pandemic H1N1 and te article made no mention of reassortment, which would have added multiple changes.
PB2 offers significant advantage in humans, which is why it is in all human flu's.