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niman
PostPosted: Tue Jan 26, 2010 11:54 am 
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The transmission of Tamiflu resistant H1N1 among patient at Duke Medical Center in October / Novermber led to the death of 3 of the 4 patients. The CDC has released the sequences (at GISAID) from those patients, confirming that they had H274Y, D225G, and D225N.

The possible connection between RBD changes and H274Y was discussed in December

http://www.recombinomics.com/News/12050 ... enial.html

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niman
PostPosted: Tue Jan 26, 2010 12:27 pm 
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It is worth noting that the samples were collected in October and November, but no announcement was made until December. The announcement just said H1N1 with H274Y spread patient to patient and the cause of death in the three patients was unclear.
The sequences have mixtures for D225G and D225N.
There was no mention of transmission in the WHO paper on D225G.

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ms4920
PostPosted: Tue Jan 26, 2010 12:37 pm 
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niman wrote:
It is worth noting that the samples were collected in October and November, but no announcement was made until December. The announcement just said H1N1 with H274Y spread patient to patient and the cause of death in the three patients was unclear.
The sequences have mixtures for D225G and D225N.
There was no mention of transmission in the WHO paper on D225G.


Can you link us to the WHO paper on all the 225 info?
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niman
PostPosted: Tue Jan 26, 2010 12:38 pm 
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ms4920 wrote:
niman wrote:
It is worth noting that the samples were collected in October and November, but no announcement was made until December. The announcement just said H1N1 with H274Y spread patient to patient and the cause of death in the three patients was unclear.
The sequences have mixtures for D225G and D225N.
There was no mention of transmission in the WHO paper on D225G.


Can you link us to the WHO paper on all the 225 info?

http://www.who.int/entity/wer/2010/wer8504.pdf

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ms4920
PostPosted: Tue Jan 26, 2010 12:58 pm 
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Thank you
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niman
PostPosted: Tue Jan 26, 2010 1:22 pm 
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Commentary

http://www.recombinomics.com/News/01261 ... 225GN.html

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niman
PostPosted: Tue Jan 26, 2010 2:23 pm 
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There are actually five NA sequences with H274Y (but two may be from the same patient), and all have the same rare HA marker,

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niman
PostPosted: Tue Jan 26, 2010 3:39 pm 
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niman wrote:
There are actually five NA sequences with H274Y (but two may be from the same patient), and all have the same rare HA marker,

On futher analysis, in addition to the two sequences with mixtures for D225G and D225N, a third sequence with a clean signal for D225G was also released, suggesting that all three fatal cases had D225G/N.

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niman
PostPosted: Tue Jan 26, 2010 5:35 pm 
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niman wrote:
ms4920 wrote:
niman wrote:
It is worth noting that the samples were collected in October and November, but no announcement was made until December. The announcement just said H1N1 with H274Y spread patient to patient and the cause of death in the three patients was unclear.
The sequences have mixtures for D225G and D225N.
There was no mention of transmission in the WHO paper on D225G.


Can you link us to the WHO paper on all the 225 info?

http://www.who.int/entity/wer/2010/wer8504.pdf

Original review

http://www.who.int/csr/resources/public ... index.html

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niman
PostPosted: Tue Jan 26, 2010 6:10 pm 
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In addition to the sequences closely related to the sequences with D225G/N is an unrelated sequence that is closely related to NC swine (both of which have a wild type RBD). PB2 sequences for the human isolate were released and they have E340N, further suggestung that E340N is a sub-clade marker and unrelated to position 225 changes.

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