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PostPosted: Fri Nov 27, 2009 2:11 am 
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Location: Pittsburgh, PA USA
Originating Laboratory
provider of clinical specimen(s)
and/or virus isolate(s) [Ukraine, Kiev] Ministry of Health of Ukraine
Address: Central Sanitary Epidemiological Station 41 Yaroslavskaya str. 04071 Kiev Ukraine
Sample ID given by the sample provider
Submitting Laboratory
generator of data [UK, London] WHO Collaborating Centre
Address: The National Institute for Medical Research (NIMR) The Ridgeway - Mill Hill London NW7 1AA, UK
Sample ID given by the sequencing lab:
Antigenic characterisation: A/California/7/2009 like. Low reactor

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PostPosted: Fri Nov 27, 2009 2:15 am 
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Location: Pittsburgh, PA USA
Isolate ID: EPI_ISL_62012
Isolate name: A/Lviv/N6/2009
Passage details/history: throat swab
Type: A / H1N1
Lineage: swl

The above isolate has been designated a low reactor by Mill Hill.

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PostPosted: Fri Nov 27, 2009 2:28 am 
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niman wrote:
Isolate ID: EPI_ISL_62012
Isolate name: A/Lviv/N6/2009
Passage details/history: throat swab
Type: A / H1N1
Lineage: swl

The above isolate has been designated a low reactor by Mill Hill.


The only protein change on the HA of the above sequence is D225G.

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PostPosted: Fri Nov 27, 2009 2:34 am 
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Joined: Sat Nov 21, 2009 1:00 am
Posts: 5
can someone explain the significance?
this is important somehow. How?


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PostPosted: Fri Nov 27, 2009 2:40 am 
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redreamer wrote:
can someone explain the significance?
this is important somehow. How?

This would fall into the EXTREMELY bad news category. It means that not only does D225G drive the H1N1 to the lungs, but it allows the virus to evade the natural immune response / vaccine.

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PostPosted: Fri Nov 27, 2009 3:28 am 
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Joined: Wed Nov 04, 2009 9:57 pm
Posts: 213
I got H1N1 3x. Don't like being sick. Just got Novartis H1N1 vaccine, single dose (way less mercury), no adjuvants.

Did I do something stupid getting that vaccine? I'm at risk, have breathing problems and like to be well and vertical. I thought the booster would help keep the recurring infection mild enough to handle.


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PostPosted: Fri Nov 27, 2009 3:36 am 
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Location: Pittsburgh, PA USA
Cascadians wrote:
I got H1N1 3x. Don't like being sick. Just got Novartis H1N1 vaccine, single dose (way less mercury), no adjuvants.

Did I do something stupid getting that vaccine? I'm at risk, have breathing problems and like to be well and vertical. I thought the booster would help keep the recurring infection mild enough to handle.

The virus still seems to be a mixture, so even though the prior exposures may select for D225G, your existing immunity may knock down the wild type and then allow for more focus on D225G. Moreover, not all H1N1 infections involve D225G.

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PostPosted: Fri Nov 27, 2009 3:39 am 
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Thx ... what does "may select for" mean? "allow for more focus?"


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PostPosted: Fri Nov 27, 2009 3:46 am 
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Joined: Mon Nov 02, 2009 7:07 pm
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More ammunition for the Luddites I'm afraid. How long until a new vaccine can be created?


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PostPosted: Fri Nov 27, 2009 3:49 am 
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Location: Pittsburgh, PA USA
Cascadians wrote:
Thx ... what does "may select for" mean? "allow for more focus?"

No, the select for refers to prior exposures generating antibodies that kill the wild type. The killing of wild type selects for D225G (it becomes dominnat because its competition (wild type) has been eliminated by the antibodies generate against wil type. Thus, after the antibodies kill off wild type, all that is left is D225G (the selection favored the survival and dominance of D225G).

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