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 Post subject: Re: ASK DR. NIMAN
PostPosted: Thu Nov 19, 2009 7:57 am 
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Posts: 127
Would it be possible to get Dr Niman's comment on the following short article about him? I just want to make sure it is accurate.

Meet the man in the middle, Dr Henry Niman

The anti vaccine crowd likes to attack Dr Niman, ignoring the fact that his research would lead to fewer vaccines / more accurate ones and try to tie him to the pharma companies.

Niman is a researcher who has developed techniques and discoveries that are used by pharma companies. Blaming him for their missteps is like blaming the man who patented power steering when Ford makes SUVs that catch on fire spontaneously.

From his own "founder" page on his company website:

Quote:
In 1982, he developed the flu monoclonal antibody, which is widely used throughout the pharmaceutical, biotech, and research industries in epitope tagging techniques. He also produced a broad panel of monoclonal antibodies against synthetic peptides of oncogenes and growth factors. These monoclonal antibodies were distributed worldwide to researchers by the National Cancer Institute. The antibodies identified novel related proteins which correlated with clinical parameters.

This technology was used to form ProgenX, a cancer diagnostic company that became Ligand Pharmaceuticals. Dr Niman subsequently identified protein expression patterns at the University of Pittsburgh. More recently, he became interested in infectious diseases while at Harvard Medical School. He then founded Recombinomics and discovered how viruses rapidly evolve. These latest findings are the subject of recent patent filings.


He's basically spent the last few years predicting the evolution of flu viruses and which ones would create epidemics / pandemics and appearing on every Internet radio show in the process no matter what subject they specialize in. He's doing this to spread the word and record proof that his novel theory on viral evolution is correct and allows him to make these predictions with amazing accuracy.

He's controversial to the mainstream medical industry which is unfortunate. They would have been able to create vaccines which would have worked perfectly for a number of years and possibly even prevented the current H1N1 pandemic if they had listened to him.

He's been attacked by some in the mainstream medical industry and been attacked by the anti-vaccine groups with vicious rumors and lies for his alleged "pro-vaccine agenda". He seems to be caught in between some in an industry that won't listen to a true innovator and the anti vaccine agenda which claims he is some kind of big pharma insider who profits heavily from vaccines.

For some reason the men and women who develop truly progressive concepts are always attacked and ridiculed in their own time. I believe history will end up on his side and future generations will benefit from his inventions.

I haven't looked into the accusations about his past because they have no bearing on his invention nor his ability to make accurate predictions because of it. I'm not an investor nor am I in a position to be affected financially by him. As a potential host for the viruses he studies the only impact Dr Niman's work might have on me would be more accurate and fewer vaccines.

Unfortunately, we are all in a position to suffer from the pharma industries refusal to use his invention. Maybe they don't want to replace yearly vaccines with a single, five or ten year vaccine or head off pandemics before they begin? It wouldn't be the first time mankind was denied something truly progressive in favor of profits and greed.


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 Post subject: Re: ASK DR. NIMAN
PostPosted: Fri Nov 20, 2009 6:35 am 
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Joined: Fri Nov 20, 2009 4:06 am
Posts: 1
First I want to express my gratitude for all the valuable informations on here.
Since my family and I live in Switzerland I have a specific question concerning the vaccination for H1N1:
In Switzerland we only have the vacc. with adjuvants/additives (squalen, thimerosal, etc.), we do not have the choice of choosing one without (like Celvapan). We have the following 3 vaccines:
Pademrix, Focetria & Celtura.
Concerning the recent development (D-225G) I would feel more comfortable to get the vaccination, if there wasn't the concern about the type of vaccination we can get.
I hope I post my question in the right place:

Dr. Niman, would you still suggest to get the vaccination with the above mentioned vaccines (Pandemrix, Focetria & Celtura)?

I know you are working on issues with higher importance then a individuals question, nevertheless I hope you find the time to answer my question.

Thank you very much for your efforts!

P.S. Answers/opinions from other board members are more then welcome!


Last edited by Manu on Fri Nov 20, 2009 6:01 pm, edited 1 time in total.

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 Post subject: Re: ASK DR. NIMAN
PostPosted: Fri Nov 20, 2009 9:51 am 
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Joined: Tue Aug 11, 2009 2:58 pm
Posts: 1400
Location: Katy, TX
Welcome to the board, Manu!

_________________
I am not a doctor, virologist, or any of type of medical/life sciences professional.

I am a layman with a background in the physical sciences.


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 Post subject: Re: ASK DR. NIMAN
PostPosted: Fri Nov 20, 2009 5:06 pm 
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Joined: Wed Aug 19, 2009 10:42 am
Posts: 27267
Location: Pittsburgh, PA USA
saraseer wrote:
According to the article at the following link, Arkansas has recently recorded two deaths from seasonal flu.
http://www.newsrunner.com/display-artic ... toll+at+18

Is this possible?

Thanks!

The article is talking about years, not seasons, so this YEAR would include the regular flu season at the beginning of 2009, when there was plenty of seasonal flu circulating (and NO swine flu). At this time however, there is NO seasonal flu in Arkansas, North America, or Europe.

_________________
www.twitter.com/hniman


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 Post subject: Re: ASK DR. NIMAN
PostPosted: Sat Nov 21, 2009 4:21 pm 
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Joined: Fri Sep 04, 2009 2:57 pm
Posts: 173
Quote:
For some reason the men and women who develop truly progressive concepts are always attacked and ridiculed in their own time. I believe history will end up on his side and future generations will benefit from his inventions.



The reason for the above comment: "The pioneers are always the ones with arrows in their backs."


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 Post subject: Re: ASK DR. NIMAN
PostPosted: Sat Nov 21, 2009 9:23 pm 
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Joined: Sat Nov 21, 2009 8:43 am
Posts: 22
Dr Niman,

I had posted the following under a different string, perhaps this is more appropriate place to ask my questions.

Thanks, in Advance.

You have stated that Peramivir will not work in regards to H1N1 with Oseltamivir resistance. I believe this is due to the H274/5Y mutation. What is the clinical evidence for this statement? I know this is a recommendation made by the CDC as well. I have attached some information regarding IC50 and peramivir resistance along with some information regarding peramvir concentration confering to this resistance. IV peramivir at 600mg appears to significantly exceed the concentrations associated with resistance. Can this resistance be overcome by increasing the concentration as seen with bacteria such as Amoxicillin and various levels of strep pneumo resistance? Is there a defined resistance level for this H274/5Y mutation and peramivir resistance based on drug concentration at which Peramivir will definitively not be clinically effective due inability to achieve sufficient concentrations to overcome resistance?

This information is for seasonal flu: "The H274Y mutation caused a 527-fold increase in peramivir IC50 (mean IC50 = 94.9 nM, equivalent to 21.6 ng/ml)(Table 2). However this value is significantly lower than the plasma concentrations of peramivir which exceed 10,000 ng/ml following a 300mg parenteral dose (Alexander et al., 2007)." http://download.thelancet.com/flatconten...

This is from the Peramivir Provider Fact Sheet: "Cross-resistance has been observed among influenza virus neuraminidase inhibitors. The oseltamivir resistance-associated substitutions E119V (A/H3N2), D198N (B), H275Y (A/H1N1), and R292K (H2N2) conferred 1, 4.8, 100 and 80 fold reductions in susceptibility to Peramivir in a neuraminidase assay, respectively....The relationship between susceptibility to Peramivir inhibition in biochemical assays and clinical efficacy has not been established."

This sesonal flu strain showed 527 fold increase in resistance at a concentration of 21.6 ng/ml whereas the information provided in the factsheet was only a 100 fold increase for H1N1 with the H275Y mutation. It was also stated int the fact sheet that "Peramivir inhibition in biochemical assays and clinical efficacy has not been established" So what is the real evidence?


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 Post subject: Re: ASK DR. NIMAN
PostPosted: Sun Nov 22, 2009 6:50 pm 
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Joined: Thu Aug 20, 2009 7:42 pm
Posts: 1533
Location: Northern California
Hi Dr. Niman,

Just wanted to see what your take was, in case you did not see the post, regarding the 2 oil rig workers, who were roommates in Texas, who died .

When you have time to answer the question, whether this should be sequenced or whether this was just a coincidence. Does not sound good, for sure.


Thank you


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 Post subject: Re: ASK DR. NIMAN
PostPosted: Mon Nov 23, 2009 4:10 pm 
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Joined: Wed Aug 19, 2009 10:42 am
Posts: 27267
Location: Pittsburgh, PA USA
ms4920 wrote:
Hi Dr. Niman,

Just wanted to see what your take was, in case you did not see the post, regarding the 2 oil rig workers, who were roommates in Texas, who died .

When you have time to answer the question, whether this should be sequenced or whether this was just a coincidence. Does not sound good, for sure.


Thank you

I am writing a commentary on this. I believe it is strong evidence for transmission of a lethal strain (such as one with D225G).

_________________
www.twitter.com/hniman


Last edited by niman on Mon Nov 23, 2009 4:38 pm, edited 1 time in total.

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 Post subject: Re: ASK DR. NIMAN
PostPosted: Mon Nov 23, 2009 4:12 pm 
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Joined: Wed Aug 19, 2009 10:42 am
Posts: 27267
Location: Pittsburgh, PA USA
solebrother wrote:
Dr Niman,

I had posted the following under a different string, perhaps this is more appropriate place to ask my questions.

Thanks, in Advance.

You have stated that Peramivir will not work in regards to H1N1 with Oseltamivir resistance. I believe this is due to the H274/5Y mutation. What is the clinical evidence for this statement? I know this is a recommendation made by the CDC as well. I have attached some information regarding IC50 and peramivir resistance along with some information regarding peramvir concentration confering to this resistance. IV peramivir at 600mg appears to significantly exceed the concentrations associated with resistance. Can this resistance be overcome by increasing the concentration as seen with bacteria such as Amoxicillin and various levels of strep pneumo resistance? Is there a defined resistance level for this H274/5Y mutation and peramivir resistance based on drug concentration at which Peramivir will definitively not be clinically effective due inability to achieve sufficient concentrations to overcome resistance?

This information is for seasonal flu: "The H274Y mutation caused a 527-fold increase in peramivir IC50 (mean IC50 = 94.9 nM, equivalent to 21.6 ng/ml)(Table 2). However this value is significantly lower than the plasma concentrations of peramivir which exceed 10,000 ng/ml following a 300mg parenteral dose (Alexander et al., 2007)." http://download.thelancet.com/flatconten...

This is from the Peramivir Provider Fact Sheet: "Cross-resistance has been observed among influenza virus neuraminidase inhibitors. The oseltamivir resistance-associated substitutions E119V (A/H3N2), D198N (B), H275Y (A/H1N1), and R292K (H2N2) conferred 1, 4.8, 100 and 80 fold reductions in susceptibility to Peramivir in a neuraminidase assay, respectively....The relationship between susceptibility to Peramivir inhibition in biochemical assays and clinical efficacy has not been established."

This sesonal flu strain showed 527 fold increase in resistance at a concentration of 21.6 ng/ml whereas the information provided in the factsheet was only a 100 fold increase for H1N1 with the H275Y mutation. It was also stated int the fact sheet that "Peramivir inhibition in biochemical assays and clinical efficacy has not been established" So what is the real evidence?

A&A. A 100X reduction in efficiency by H274Y (as noted above in the package insert) renders Paramivir useless against pandemic H1N1 with H274Y, as indicated by the CDC statement.

_________________
www.twitter.com/hniman


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 Post subject: Re: ASK DR. NIMAN
PostPosted: Mon Nov 23, 2009 4:17 pm 
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Joined: Wed Aug 19, 2009 12:46 pm
Posts: 212
ecoparity wrote:
Would it be possible to get Dr Niman's comment on the following short article about him? I just want to make sure it is accurate.

Meet the man in the middle, Dr Henry Niman



Link?


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