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PostPosted: Fri Apr 01, 2011 12:52 pm 
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Joined: Sun Jan 23, 2011 9:38 pm
Posts: 149
Location: Florida
Now the majority of pH1N1 samples in Europe no longer match A/California/7/2009 A(H1N1) and there are more from the A/England/142/2010 subclade than from the A/California/7/2009 clade. I would expect to see a similar divergence in the U.S., which would likely explain why severe cases and deaths have occurred in some states where pH1N1 is circulating and not in others.

This should be sufficient evidence to stop public health officials in the U.S. from stating that the specimens collected are a good match to the vaccine.

The following is from the Week 12 EuroFlu Bulletin - http://www.euroflu.org/cgi-files/bulletin_v2.cgi
Quote:
Based on the genetic characterization of 359 influenza viruses:

  • 77 belonged to the pandemic A/California/7/2009 A(H1N1) clade;
  • 10 belonged to the pandemic A/Christchurch/16/2010 A(H1) clade;
  • 46 belonged to the pandemic A/Hong Kong/2213/2010 A(H1) clade;
  • 81 belonged to the recently emerged A/England/142/2010 subgroup characterized by S185T substitution in the HA;
  • 11 belonged to the A(H3) clade represented by A/Perth/16/2009;
  • 4 belonged to the A(H3) clade represented by A/Victoria/208/2009;
  • 18 belonged to the subgroup represented by A/Hong Kong/2121/2010 in the A/Victoria/208/2009 A(H3) clade;
  • 19 belonged to the B/Bangladesh/3333/2007 clade (Yamagata lineage), and
  • 93 to the B/Brisbane/60/2008 clade (Victoria lineage).

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PostPosted: Fri Apr 01, 2011 12:59 pm 
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Joined: Wed Aug 19, 2009 10:42 am
Posts: 48151
Location: Pittsburgh, PA USA
Jim wrote:
Now the majority of pH1N1 samples in Europe no longer match A/California/7/2009 A(H1N1) and there are more from the A/England/142/2010 subclade than from the A/California/7/2009 clade. I would expect to see a similar divergence in the U.S., which would likely explain why severe cases and deaths have occurred in some states where pH1N1 is circulating and not in others.

This should be sufficient evidence to stop public health officials in the U.S. from stating that the specimens collected are a good match to the vaccine.

The following is from the Week 12 EuroFlu Bulletin - http://www.euroflu.org/cgi-files/bulletin_v2.cgi
Quote:
Based on the genetic characterization of 359 influenza viruses:

  • 77 belonged to the pandemic A/California/7/2009 A(H1N1) clade;
  • 10 belonged to the pandemic A/Christchurch/16/2010 A(H1) clade;
  • 46 belonged to the pandemic A/Hong Kong/2213/2010 A(H1) clade;
  • 81 belonged to the recently emerged A/England/142/2010 subgroup characterized by S185T substitution in the HA;
  • 11 belonged to the A(H3) clade represented by A/Perth/16/2009;
  • 4 belonged to the A(H3) clade represented by A/Victoria/208/2009;
  • 18 belonged to the subgroup represented by A/Hong Kong/2121/2010 in the A/Victoria/208/2009 A(H3) clade;
  • 19 belonged to the B/Bangladesh/3333/2007 clade (Yamagata lineage), and
  • 93 to the B/Brisbane/60/2008 clade (Victoria lineage).

The above collections go back to week 40 of 2010. For December, 2010 through 2011, the dominant subclade is the England/142 sub-clade with S188T (called S185T above).

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