Rhiza Labs FluTracker Forum

Cor , night-mare log in....not been on since last year!

We had H1N1 last year (so we were told) .We had another bout prior to this Chrimbo (?) and it was Sooo much worse than the first 'bout' (still not 100%). Our son is 'special needs' and needed 2 lots of Anti -bio's (and lots of nebulisor attention!) before it cleared (he had the initial 'Jab' for H1N1 last year)

My Dad was a victim in Aug 09 but his death cert did not mention H1N1 (pnumonia/Kidney failure)

My partner is out at a funeral for a pal who died before Chrimbo...sudden (unexpected Heart attack) but on oxygen prior to second fatal one? (first 'brick wall' of temp and chest shut down putting extra strain on heart??). My sons 'teaching assistant' (52) died suddenly on the 23rd from chest infection.

Our carers have all fallen foul , one was told today (by her G.P.) that they needed hopitalisation but opted for 'home care' and a pnumonia jab (plus ant-bio's).

This has fallen all wrong with the 'party season' exposing many of the 'at risk' groups (as we hear in the BBC leicster Vid) to the virus. We are all out of 'oxygenation units' as they are all in use, we (I imagine) are yet to see the bulk of infections as the main 'wave' will only be starting around now (and many 'with it' will be out tonight not knowing they are shedding virus). I did not 'slowly' become ill. I was well at 2a.m. , I could not move (to get meds) by 5 a.m. If this is the pattern for many then they will be 'out and about' their business right up to the 'collapse' and ,as such ,will be highly contagious for a day or so without suspecting they are just about to be ill.

The next 3 weeks will prove 'crux' (I believe) as the bulk of folk who will fall ill (2/3 of the population have not 'had it' we are told) will do so in this period. Top that off with the kiddies back in school next week (meaning those catching it around their return to school will be bad over next weekend) and we have a recipe for dissaster.

Let's hope our situation will prove a lesson to the rest of the N.Hemisphere?

Cor , night-mare log in....not been on since last year!

We had H1N1 last year (so we were told) .We had another bout prior to this Chrimbo (?) and it was Sooo much worse than the first 'bout' (still not 100%). Our son is 'special needs' and needed 2 lots of Anti -bio's (and lots of nebulisor attention!) before it cleared (he had the initial 'Jab' for H1N1 last year)

My Dad was a victim in Aug 09 but his death cert did not mention H1N1 (pnumonia/Kidney failure)

My partner is out at a funeral for a pal who died before Chrimbo...sudden (unexpected Heart attack) but on oxygen prior to second fatal one? (first 'brick wall' of temp and chest shut down putting extra strain on heart??). My sons 'teaching assistant' (52) died suddenly on the 23rd from chest infection.

Our carers have all fallen foul , one was told today (by her G.P.) that they needed hopitalisation but opted for 'home care' and a pnumonia jab (plus ant-bio's).

This has fallen all wrong with the 'party season' exposing many of the 'at risk' groups (as we hear in the BBC leicster Vid) to the virus. We are all out of 'oxygenation units' as they are all in use, we (I imagine) are yet to see the bulk of infections as the main 'wave' will only be starting around now (and many 'with it' will be out tonight not knowing they are shedding virus). I did not 'slowly' become ill. I was well at 2a.m. , I could not move (to get meds) by 5 a.m. If this is the pattern for many then they will be 'out and about' their business right up to the 'collapse' and ,as such ,will be highly contagious for a day or so without suspecting they are just about to be ill.

The next 3 weeks will prove 'crux' (I believe) as the bulk of folk who will fall ill (2/3 of the population have not 'had it' we are told) will do so in this period. Top that off with the kiddies back in school next week (meaning those catching it around their return to school will be bad over next weekend) and we have a recipe for dissaster.

Let's hope our situation will prove a lesson to the rest of the N.Hemisphere?

Eleven swine flu cases confirmed in Jersey

Eleven people in Jersey have been confirmed as having swine flu, with tests being carried out in other suspected cases of the H1N1 flu strain.

No-one has needed hospital treatment but the island's health department said it was monitoring the situation.

Dr Susan Turnball has urged islanders to have the seasonal flu vaccine, particularly pregnant women and people with asthma or diabetes.

Last year £1m was spent fighting the spread of swine flu in Jersey

We may find this set of sequences to be instructive to the UK severe wave in the days to come when NIMR releases sequences.

HA 230I Cross-Linked in Slovakia on Broad Background

Last Updated 2010-12-31

The UK National Institute for Medical Research published a group of sequences on 2010-12-30 at GISAID. One group originated from the National Public Health Institute of Slovakia.

An unusual and persistent background pivoting around 8 polymorphisms on 5 sequences arose during March 2010 in Slovakia pairing two silent polymorphisms for the first time (syn23L and syn177L (CTt)). The Slovakian sequences are all cross-linked with the HA syn413K and the NA syn407V.

Of particular interest is the Slovakia1625_56X_2010_03_30_xL from a 56 year old of unspecified gender due to the 9th polymorphism, a very rare HA 230I. As of this deposit, the multiple backgrounds that are permissive to the HA 230I change extends to a new platform that appears to transmit (5 geographically similar sequences in 5 days).

GeneWurx has prepared an Excel spreadsheet investigating potential genetic acquisition in the currently uncharted severe Pandemic H1N1 wave in the UK. In Version 1 of this spreadsheet, the Slovakian 230I sequence takes Column U and provides homology to one UK White Chapel sequence of interest.

GeneWurx_UK_December_Emerging_Genetics_v1.xls

. . . . Slovakia1625_56X_2010_03_30_xL (
. . . . . . . . syn23L,
. . . . . . . . 100N,
. . . . . . . . syn177L (CTt),
. . . . . . . . syn216E,
. . . . . . . . 230I (ATa),
. . . . . . . . 324I,
. . . . . . . . syn400F,
. . . . . . . . syn413K,
. . . . . . . . 461E [UKEngland712_2009_09 with 24K])

. . . . Slovakia1623_39X_2010_03_30_xL (
. . . . . . . . syn23L,
. . . . . . . . 100N,
. . . . . . . . syn177L (CTt),
. . . . . . . . syn216E,
. . . . . . . . 324I,
. . . . . . . . syn400F,
. . . . . . . . syn413K,
. . . . . . . . 452I,
. . . . . . . . 461E [UKEngland712_2009_09 with 24K])

. . . . Slovakia1624_61X_2010_03_30_xL (
. . . . . . . . syn23L,
. . . . . . . . 100N,
. . . . . . . . syn177L (CTt),
. . . . . . . . syn216E,
. . . . . . . . 324I,
. . . . . . . . syn400F,
. . . . . . . . syn413K,
. . . . . . . . 461E [UKEngland712_2009_09 with 24K])

. . . . Slovakia1626_59X_2010_03_30_xL (
. . . . . . . . syn23L,
. . . . . . . . 100N,
. . . . . . . . syn177L (CTt),
. . . . . . . . syn216E,
. . . . . . . . 324I,
. . . . . . . . syn400F,
. . . . . . . . syn413K,
. . . . . . . . 461E [UKEngland712_2009_09 with 24K])

. . . . Slovakia1634_42X_2010_04_03_xL (
. . . . . . . . syn23L,
. . . . . . . . 100N,
. . . . . . . . syn177L (CTt),
. . . . . . . . syn216E,
. . . . . . . . 324I,
. . . . . . . . syn400F,
. . . . . . . . syn413K,
. . . . . . . . 461E [UKEngland712_2009_09 with 24K])
Supporting Sequences

. . . . UKEngland712_2009_09 (
. . . . . . . . 24K,
. . . . . . . . syn413K,
. . . . . . . . syn456L,
. . . . . . . . 461E [Slovakia1625_56X_2010_03_30_xL with 230I])

. . . . DenmarkHvidovreINS141_2009_11_20_xL (
. . . . . . . . syn23L,
. . . . . . . . syn238E,
. . . . . . . . 324I,
. . . . . . . . syn413K,
. . . . . . . . syn484N,
. . . . . . . . syn549R)

. . . . Victoria508_2010_07_24 (
. . . . . . . . 35I [H5N1],
. . . . . . . . 88P [H2N3, H5N1, H11],
. . . . . . . . . . . [HunanHechengSWL1616_2009-11-23,
. . . . . . . . . . . KoreaAF2376_2009_10_27
. . . . . . . . . . . . . . . with 280A and 290K],
. . . . . . . . syn102E [SingON2407_2009_12_13,
. . . . . . . . . . . . . . . Singapore544_2009_12_10,
. . . . . . . . . . . . . . . Brussels243_2009_11_09
. . . . . . . . . . . . . . . . . . . . with syn44L and 89G],
. . . . . . . . syn152I [CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07
. . . . . . . . . . . . . . . . . . . . with 35I, syn219I, syn276H, syn456L, 463V, 523A,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . syn219I [CalifVRDL115_2009_12_04
. . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H, syn456L, 463V, 523A,
. . . . . . . . . . . . . . FL_Pen213_2009_11_17
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, 273A, syn456L, 463V, 523A,
. . . . . . . . . . . . . . CalifVRDL107_2009_11_15
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H, syn456L, 463V, 523A,
. . . . . . . . 238D (GAc) [H2N3, H7N3, H7N7],
. . . . . . . . . . . . . . . . . . [Belgorod2_2010-03-15 (GAt),
. . . . . . . . . . . . . . . . . . Kaliningrad01_2009_11_02 (GAt)
. . . . . . . . . . . . . . . . . . . . . . . . with 225E and 226R,
. . . . . . . . . . . . . . . . . . AthensINS398_2010-01-24 GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_DA_2009-09-26 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_KG_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_MA_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_SHD_2009-09-25 (GAt),

. . . . . . . . . . . . . . . . . . KaliningradCRIE_ZD_2009-09-25 (GAt)],
. . . . . . . . syn247A [Belize8756_2009_10_08,
. . . . . . . . . . . . . . . Singapore93_2009_06_22]
. . . . . . . . syn254P,
. . . . . . . . 272G [Niigata19_2009_12_31,
. . . . . . . . . . . . GuangdongSWL36_2009_11_29],
. . . . . . . . syn276H,
. . . . . . . . syn388K [H5N1],
. . . . . . . . . . . . . . . [NagasakiHA_10_28_2010_03_23
. . . . . . . . . . . . . . . . . . . . . with 22I,
. . . . . . . . . . . . . . . NagasakiHA_10_26_2010_03_15
. . . . . . . . . . . . . . . . . . . . . with 22I, syn103E,
. . . . . . . . . . . . . . . NagasakiHA_10_24_2010_03_08
. . . . . . . . . . . . . . . . . . . . . with syn103E,
. . . . . . . . . . . . . . . GuangxiLonganSWL1990_2010_02_08
. . . . . . . . . . . . . . . . . . . . . with 453K, syn462E,
. . . . . . . . . . . . . . . JiangxiDonghuSWL15_2010_01_04
. . . . . . . . . . . . . . . . . . . . . with syn106E, 149R, syn456L (TTg),
. . . . . . . . . . . . . . . ViennaINS142_2009_11_26
. . . . . . . . . . . . . . . . . . . . . with syn97D, 99T,
. . . . . . . . . . . . . . . CzechUsti208_2009_11_25
. . . . . . . . . . . . . . . . . . . . . with 268T,
. . . . . . . . . . . . . . . GhanaFS_1921_2009_11_11,
. . . . . . . . . . . . . . . Alaska44_2009_11_17
. . . . . . . . . . . . . . . . . . . . . with syn275V, 276N,
. . . . . . . . . . . . . . . CalifVRDL76_2009_09_21
. . . . . . . . . . . . . . . . . . . . . with syn283Q,
. . . . . . . . . . . . . . . Taiwan206_2009_09_18,
. . . . . . . . . . . . . . . Taiwan177_2009_09_18,
. . . . . . . . . . . . . . . Taiwan167_2009_09_18,
. . . . . . . . . . . . . . . Taiwan156_2009_09_18,
. . . . . . . . . . . . . . . Taiwan143_2009_09_15
. . . . . . . . . . . . . . . . . . . . . with 205E mix,
. . . . . . . . . . . . . . . Utah20_C2_2_2009_07_25_VxX
. . . . . . . . . . . . . . . . . . . . . with 159D, 206S, 227G
. . . . . . . . . . . . . . . Slovenia2687_2009_07_01
. . . . . . . . . . . . . . . . . . . . . with 35I, 206S],
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 523A [Nebraska02_2010_03_11,
. . . . . . . . . . . . NagasakiHA1022_2010_03_01_syn413K,
. . . . . . . . . . . . DomRepublic3768_2009_12_15,
. . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . RheinlandPfalz81_2009_11_23,
. . . . . . . . . . . . Berlin210_2009_11_16,
. . . . . . . . . . . . BadenWurttemberg511_2009_11_16,
. . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . FL_Pensacola40_2009_11_09,
. . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . DC114_2009_11_04,
. . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . KuwaitN13013_2009_08_31_syn413K]),
__________________

Commentary

http://www.recombinomics.com/News/12311 ... er_12.html

ECMO machines are already stretched to the limit, and the dramatic increases in severe cases signal a major pandemic concern that requires aggressive action.

Hi Stephensons!

Just the wrong time of year for everything including 'News'?

I agree with Niman on the 'under-reporting' of deaths.

We had a 'spike' in the overall death rate (well above predicted numbers for the time of year?) before Christmas but no update since? I don't know whether that is due out today or whether New Year will delay it. It is a thing to watch, I feel, as if we see a big rise in Heart Attack/Pnumonia/Kidney failure deaths I know where I'd be looking for the 'initial cause' (like our under-reporting of hypothermia deaths in the elderly? cause of death on the cert not that which put them there?). If we are seeing a virus on the cusp of changing beyond the defences of the Vaccine then what other changes may we be seeing? If there are 2 componants to the virus, 1 upper resp. the other a slow spread to lower resp. tract then we will see a lot of young, fit ,folk become very ill. We are told we have nearly 4/5 of our I.C.U. beds available and contingency for a doubling of capacity but that gives us 7,ooo beds total. Who will put in the extra 'care' of such a number??? How many of those will need a spell on 'the machine' (with them all, 20 of them, in use).

Come tues or wed's we should be open to the possibility of a huge upsurge in infections (folk already exposing themselves to the virus?) and it is those numbers we need to watch. If the 'vaccine' is less and less effectual then health care personel will also fall foul of the illness (remember all those I.C.U. beds? all those 'extra I.C.U. nurses?)

We also have the worry of the 'tamiflu resistance'.....let's hope that is just a worry and not a 'trend'?

A hike in mortality rates will not be hidden for long as , as in my case, folk will 'know of folk' who have secumbbed and that news will travel.

If we make it through the next 3 weeks without things getting 'odd' then I feel we will be OK but I do worry at present as to the levels of ICU occupancy compared to last years 'peak' in cases.

Less with it yet more very poorly?

So, let us wait and see a while longer?

Flu outbreak piles pressure on 'critical care' units
Department of Health reports 60% increase this week in serious cases, forcing hospitals to delay operations.

The number of people critically ill with flu in hospitals in England has risen by 60% in a week, putting pressure on intensive care and high dependency units and forcing the delay of some non-urgent operations.

The Department of Health said today that 738 people with confirmed or suspected flu were in "critical care" beds, a substantial rise on last week's figure of 460. They include 42 children under five.

The figures mean about one in five critical care beds are now occupied by flu patients. Bob Winter, president of the Intensive Care Society, called the figures "a concern" but not so bad that contingency plans to increase capacity had to be put into full effect...............................