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PostPosted: Mon Apr 29, 2013 5:26 am 
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gsgs wrote:
no mutation jumping, please.

You are as lost as ever.

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PostPosted: Mon Apr 29, 2013 5:43 am 
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niman wrote:
Dingo wrote:
niman wrote:
Spot On.


I'm learning. ;)

Does H7N9 have any H3N2 bits in it?

Q226I and M230I are in H3N2 and D225G is in H3N2v.


Thanks.

Are they present in the H7N9 poultry sequences?


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PostPosted: Mon Apr 29, 2013 5:53 am 
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Dingo wrote:
niman wrote:
Dingo wrote:

I'm learning. ;)

Does H7N9 have any H3N2 bits in it?

Q226I and M230I are in H3N2 and D225G is in H3N2v.


Thanks.

Are they present in the H7N9 poultry sequences?

D225G and M230I (as well as Q226L) are all in poultry.

The key differences between the human H7N9 sequences and poultry are H7 L226I and PB2 E627K.
Both of these changes are ABSENT in poultry but present in human H7N9 and H3N2 seasonal.

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PostPosted: Mon Apr 29, 2013 5:56 am 
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niman wrote:
D225G and M230I (as well as Q226L) are all in poultry.

The key differences between the human H7N9 sequences and poultry are H7 L226I and PB2 E627K.
Both of these changes are ABSENT in poultry but present in human H7N9 and H3N2 seasonal.


Thanks.

Do the red bits encourage H2H transmission?


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PostPosted: Mon Apr 29, 2013 5:58 am 
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Dingo wrote:
niman wrote:
D225G and M230I (as well as Q226L) are all in poultry.

The key differences between the human H7N9 sequences and poultry are H7 L226I and PB2 E627K.
Both of these changes are ABSENT in poultry but present in human H7N9 and H3N2 seasonal.


Thanks.

Do the red bits encourage H2H transmission?

YES

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PostPosted: Mon Apr 29, 2013 6:02 am 
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niman wrote:
Dingo wrote:
niman wrote:
D225G and M230I (as well as Q226L) are all in poultry.

The key differences between the human H7N9 sequences and poultry are H7 L226I and PB2 E627K.
Both of these changes are ABSENT in poultry but present in human H7N9 and H3N2 seasonal.


Thanks.

Do the red bits encourage H2H transmission?

YES


Thanks


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PostPosted: Mon Apr 29, 2013 6:05 am 
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no

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no patents on genes, publish the GISAID sequences !


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PostPosted: Mon Apr 29, 2013 6:06 am 
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gsgs wrote:
no

UTTER NONSENSE

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PostPosted: Mon Apr 29, 2013 7:06 am 
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gsgs wrote:
no

Are you trying to claim that H7 L226I and PB2 E627K don't increase HUMAN transmission??????????????

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PostPosted: Mon Apr 29, 2013 8:09 am 
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seems to increase transmission inside humans

But the question was:

> Do the red bits encourage H2H transmission?


it looks like E627K, as well as D701N and Q226L and L226I
all develope or are selected for in the specified humans.
We have no molecular evidence for H2H here (IMO)

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