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The Iowa State University Veterinary Department / USDA have released a large series of swine sequences (at Genbank) largely from late 2011 and 2012. Included were sets of sequences from four isolates with H3 closely related to the H3N2v sequences from human cases. All four isolates also had an H1N1pdm09 M gene. In the past, all such isolates with H3 and M genes matching the human 2011 and 2012 case also matched in all other genes with the exception of N2, which was human and related to seasonal H3n2 from 2003, but evolved into two distinct linages in swine (the initial 2011 human cases were from a swine H1N2 lineage, while the three most recent cases included an N2 from swine H3N2 lineage.
The of the recently released sequences matched the initial 2011 human cases, but one of the recent swine isolates, A/swine/Illinois/A00857318a/2012, matched 7 of the 8 genes. The NP gene however was from H1N1pdm09, raising concerns that this novel constellation could jump from swine to humans.
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