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PostPosted: Sun Jan 22, 2012 2:52 pm 
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The mainland authorities say a man has died of H5N1 bird flu in Guizhou province, and they have notified the Centre for Health Protection in Hong Kong.
The Ministry of Health said the patient was a 39-year-old man who developed symptoms on January 6 and died after three days in intensive care.



The man did not report having been in contact with poultry before the onset of symptoms.

Last month, a 39-year-old man in Shenzhen died after being diagnosed with bird flu.

The authorities there said at the time that he hadn't had any direct contact with poultry during the previous month.

But a specialist in infectious diseases, Doctor Lo Wing-lok, said poultry should still be suspected as the probable source of infection.

http://rthk.hk/rthk/news/englishnews/ne ... &56&813561

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PostPosted: Sun Jan 22, 2012 3:06 pm 
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niman wrote:

The authorities there said at the time that he hadn't had any direct contact with poultry during the previous month.

But a specialist in infectious diseases, Doctor Lo Wing-lok, said poultry should still be suspected as the probable source of infection.

http://rthk.hk/rthk/news/englishnews/ne ... &56&813561

More denials of the wild birds source of the H5N1.

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PostPosted: Sun Jan 22, 2012 3:07 pm 
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niman wrote:
niman wrote:

The authorities there said at the time that he hadn't had any direct contact with poultry during the previous month.

But a specialist in infectious diseases, Doctor Lo Wing-lok, said poultry should still be suspected as the probable source of infection.

http://rthk.hk/rthk/news/englishnews/ne ... &56&813561

More denials of the wild birds spurce of the H5N1.

Same denial cited for Shenzhen:

The victim developed a fever on December 21 and was sent to hospital on December 25 with severe pneumonia. On Saturday he was confirmed to have H5N1.

The center said earlier that Chen regularly visited the wetland at Waterlands Resort for morning exercise.

About 120 people who had close contact with him have not developed any abnormal symptoms, health authorities said.

The Guangdong Department of Agriculture announced on Saturday that no epidemic of bird flu among poultry has been reported in the province.

Hong Kong infectious diseases specialist Lo Wing-lok criticized the center's report as "confusing" and "nonsense."

Lo said: "They cannot say that the virus is similar to that found in wild birds and say Chen may have contracted the virus from wild birds.

"There is no evidence in the whole world that suggests people contract H5N1 through wild birds. It is always through poultry.

"Does that mean the virus simply fell from the sky?"

http://www.thestandard.com.hk/news_prin ... 18460&sid=

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PostPosted: Sun Jan 22, 2012 3:55 pm 
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Incredible!!! or maybe transmission is h2h, human to human!


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PostPosted: Sun Jan 22, 2012 4:05 pm 
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The communication and the truth is not the key point of China!


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PostPosted: Sun Jan 22, 2012 6:59 pm 
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A man died in southern China on Sunday from the H5N1 bird flu virus, the Health Ministry reported. It was China’s second such death in less than a month.
The latest victim, an unidentified 39-year-old, fell ill on Jan. 6 and was admitted to a hospital in Guizhou Province the same day, the Health Ministry said in a statement reported by Xinhua, the official news agency.

A 39-year-old bus driver in Shenzhen, a city in Guangdong Province near Hong Kong, died of the disease on Dec. 31.

Both deaths were notable because neither victim reported any contact with birds in the month preceding his illness. The virus is known to spread through contract with infected birds, eggs or bird feces, but experts said a pandemic could occur were it to mutate into a form that was more easily spread.

In the latest case, the victim “did not report obvious exposure history to poultry before the onset of symptoms,” according to the bulletin from Hong Kong. But the Chinese authorities, who are monitoring 71 people known to have been in contact with the victim, have found no other evidence of flu, the ministry reported.

People who were in contact with the Shenzhen victim also have remained symptom-free, leading some experts to conclude that neither case involved transmission among humans. On Sunday, Chinese censors generally blocked Internet users from reading reports of the latest death.

Worldwide, bird flu has killed 343 of the 582 people who are known to have been infected, according to the World Health Organization, including 28 of the 42 infected Chinese victims. With the world’s largest poultry population, and close contact between birds and people in rural areas, China is regarded as a major breeding ground for the disease.

Vietnam has reported 60 deaths, including that of an 18-year-old duck farmer last week. A victim in Indonesia also recently died.

http://www.nytimes.com/2012/01/23/world ... month.html

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PostPosted: Sun Jan 22, 2012 7:10 pm 
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niman wrote:
A man died in southern China on Sunday from the H5N1 bird flu virus, the Health Ministry reported. It was China’s second such death in less than a month.
On Sunday, Chinese censors generally blocked Internet users from reading reports of the latest death.

http://www.nytimes.com/2012/01/23/world ... month.html

Sequences from Shezhen case were promptly reelased. No sequences yet on Guizhou case.

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PostPosted: Sun Jan 22, 2012 7:21 pm 
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http://news.ninemsn.com/health/8407168/ ... u-in-china

A 39-year-old man has died from avian flu in China, in the second death in less than a month from the virulent H5N1 strain.

The man fell ill with a fever on January 6, and died on Sunday in a hospital in Guiyang, the capital of Guizhou province, after three days in intensive care, the Xinhua news agency reported.

On December 31, a bus driver died from bird flu in the city of Shenzhen, bordering Hong Kong.

According to a World Health Organization (WHO) update on Friday, there have been 582 confirmed human cases for avian flu and 343 deaths since 2003. WHO reports only laboratory cases.

Experts have repeatedly warned that the H5N1 strain carries the threat of a global pandemic if it mutates into a form that is more easily transmitted between humans.

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PostPosted: Mon Jan 23, 2012 4:52 am 
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For Shezhen case, A/Guangdong-Shenzhen/1/2011, the sample was collected on December 28, 2011 and sequences for 5 of the 8 gene segemnts were released on January 4, 2012

http://www.recombinomics.com/News/01041 ... S227R.html

which was followed by release of the remaining 3 gene segments by Jan 8

viewtopic.php?f=5&t=7823&start=14

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PostPosted: Mon Jan 23, 2012 5:00 am 
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Shenzhen case had Q196K. Iraq cluster had Q196R, as was also seen in recent study:

In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificityLi-Mei Chena, 1, Ola Blixtb, d, 1, 2, James Stevensa, c, Aleksandr S. Lipatova, Charles T. Davisa, Brian E. Collinsb, d, Nancy J. Coxa, James C. Paulsonb, d, 1, Ruben O. Donisa, , 1,

Purchase a Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, United States
b Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States
c Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States
d Glycan Array Synthesis Core-D, Consortium for Functional Glycomics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States
Received 27 August 2011; revised 26 September 2011; Accepted 10 October 2011. Available online 5 November 2011.


Abstract
Acquisition of α2-6 sialoside receptor specificity by α2-3 specific highly-pathogenic avian influenza viruses (H5N1) is thought to be a prerequisite for efficient transmission in humans. By in vitro selection for binding α2-6 sialosides, we identified four variant viruses with amino acid substitutions in the hemagglutinin (S227N, D187G, E190G, and Q196R) that revealed modestly increased α2-6 and minimally decreased α2-3 binding by glycan array analysis. However, a mutant virus combining Q196R with mutations from previous pandemic viruses (Q226L and G228S) revealed predominantly α2-6 binding. Unlike the wild type H5N1, this mutant virus was transmitted by direct contact in the ferret model although not by airborne respiratory droplets. However, a reassortant virus with the mutant hemagglutinin, a human N2 neuraminidase and internal genes from an H5N1 virus was partially transmitted via respiratory droplets. The complex changes required for airborne transmissibility in ferrets suggest that extensive evolution is needed for H5N1 transmissibility in humans.

Keywords: Highly pathogenic avian influenza virus; Hemagglutinin; Host cell receptor; Virus attachment; H5N1; Sialoglycan; Host range; Pandemic virus emergence

http://www.sciencedirect.com/science/ar ... 2211004752

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