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PostPosted: Wed Nov 23, 2011 6:15 am 
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Health authorities in the United States reported three new cases of infections associated with a new influenza virus of swine origin. The health officials in Iowa, where cases have been observed, seems to argue that quite clear that transmission from person to person is involved. The state epidemiologist, Dr. Patricia Quinlisk, says none of the three infected children has been in contact with pigs. However, they have been in contact with each other. It appears that a child would have transmitted the virus to the other two, but it is unclear how the child has himself been infected, said Dr. Quinlisk. These three new cases posing to ten the number of Americans infected with the H3N2 virus of swine origin, a common strain than the H3N2 viruses of human origin. No cases have been detected in Canada. The virus appears to cause minor health problems.

http://www.journalmetro.com/ma%20vie/ar ... etats-unis

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PostPosted: Wed Nov 23, 2011 6:59 am 
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niman wrote:
"It possible that the virus is being seeded and is being transmitted in short transmission chains," Cox admitted.

http://www.mysask.com/portal/site/main/ ... cachetoken

CDC in denial of sustained trH3N2 H2H transmission.

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PostPosted: Wed Nov 23, 2011 7:02 am 
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niman wrote:
niman wrote:
"It possible that the virus is being seeded and is being transmitted in short transmission chains," Cox admitted.

http://www.mysask.com/portal/site/main/ ... cachetoken

CDC in denial of sustained trH3N2 H2H transmission.

Commentary

http://www.recombinomics.com/News/11231 ... enial.html

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PostPosted: Wed Nov 23, 2011 7:46 am 
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I have contacted GISAID and Genbank to get the status of the sequences from the three cases, which are supposed to be released today by the CDC.

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PostPosted: Wed Nov 23, 2011 8:09 am 
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niman wrote:
niman wrote:
Iowa department of Public Health has announced three trH3N2 Cases.

http://www.idph.state.ia.us/IdphNews/Re ... DF9400B43D

Flu Activity in Iowa Includes Novel Strain

“It appears the seasonal influenza vaccine currently available may offer some protection against this novel strain,” said IDPH Medical Director, Dr. Patricia Quinlisk. http://www.idph.state.ia.us/Cade/Influe ... pg=FluHome .

Contact Information: Polly Carver-Kimm at (515) 281-6693

More media myths. The data on cross reactivities between the current seasonal H3N2 vaccine and the novel trH3N2 was published in the WHO update on pandemic vaccines, and there was virtually no cross reactivity (titer of 10 vs 640 for seasonal H3N2)
http://www.who.int/influenza/resources/ ... update.pdf

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PostPosted: Wed Nov 23, 2011 8:44 am 
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Commentary

http://www.recombinomics.com/News/11231 ... ne_MM.html

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PostPosted: Wed Nov 23, 2011 10:15 am 
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Commentary

http://www.recombinomics.com/News/11231 ... US_SS.html

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PostPosted: Wed Nov 23, 2011 10:30 am 
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Sequences are at GISAID
A/Iowa/09/2011
A/Iowa/08/2011
A/Iowa/07/2011

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PostPosted: Wed Nov 23, 2011 10:36 am 
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niman wrote:
Sequences are at GISAID
A/Iowa/09/2011
A/Iowa/08/2011
A/Iowa/07/2011

Thread on sequences has been started

viewtopic.php?f=5&t=7728

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PostPosted: Wed Nov 23, 2011 1:30 pm 
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Published Date: 2011-11-23 08:59:55
Subject: PRO/AH/EDR> Influenza (69): USA (IA) swine-origin H3N2 reassortant
Archive Number: 20111123.3430

INFLUENZA (69): USA (IOWA) SWINE-ORIGIN H3N2 REASSORTANT
********************************************************

A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org
In this posting:[1] CIDRAP News report[2] Iowa Department of Health report******[1] CIDRAP News reportDate: Tue 22 Nov 2011Source: CIDRAP (Center for Infectious Disease Research & Policy) News[edited]http://www.cidrap.umn.edu/cidrap/content/influenza/swineflu/news/nov2211swine.html


Iowa reports 3 novel swine-origin H3N2 cases
--------------------------------------------
Health officials in Iowa announced today [Tue 22 Nov 2011] they have
identified novel swine influenza A/H3N2 infections in 3 children,
similar to cases that have been identified over the past months in a
handful of other states [see ProMED-mail archived postings below].

The Iowa Department of Public Health (IDPH) said in a statement
[reproduced below] that routine surveillance turned up the novel virus
in Webster and Hamilton counties. The virus is a swine-origin
triple-recombinant H3N2 that includes the matrix gene from the 2009
H1N1 virus.

Though patients in other states had animal exposure or a contact who
had animal exposure, Iowa's recombinant H3N2 cases appear to have a
human-to-human spread component, according to the statement. The IDPH
said spread is so far limited, and no other cases have been identified
in the past week.

Symptoms are similar to seasonal flu and include fever, cough,
tiredness, body aches, and loss of appetite, according to the IDPH.
None of the patients were seriously ill, and all have recovered. Dr
Patricia Quinlisk, IDPH medical director, said in the statement that
the seasonal flu vaccine may offer some protection against the novel
strain, and she stressed the importance of personal protective
measures such as covering coughs and sneezes and staying home when
sick. Because the virus is unique, the IDPH said it is increasing
surveillance for it through clinics and emergency rooms.

The cases appear to push the nation's total to 10 triple-recombinant
H3N2 cases reported since September [2011]. On 4 Nov 2011 the US
Centers for Disease Control and Prevention (CDC) said it confirmed the
6th and 7th cases, in patients in Maine and Indiana. Cases have also
been detected in Pennsylvania.

The CDC, however, has said that it doesn't expect the seasonal flu
vaccine to protect against the novel strain. However, according to the
CDC, swine-origin viruses have shown sensitivity to the antiviral
drugs oseltamivir (Tamiflu) and zanamivir (Relenza), it said.

[Byline: Lisa Schnirring]

--
Communicated by:
ProMED-mail


******
[2] Iowa Department of Health report
Date: Tue 22 Nov 2011
Source: Iowa Department of Health (IDPH) News [edited]
http://www.idph.state.ia.us/IdphNews/Re ... DF9400B43D


Flu activity in Iowa includes novel strain
------------------------------------------
Routine surveillance by the Iowa Department of Public Health (IDPH),
the State Hygienic Lab and other partners across the state indicate
that a novel strain of the influenza virus has been detected in 3
children in Webster and Hamilton Counties. This virus, an influenza
A/H3N2 recombinant [reassortant] virus, has also been detected in
other states in recent months. Symptoms are similar to the regular
seasonal flu and include fever, cough, tiredness, body aches, and loss
of appetite.

This influenza A/H3N2 virus contains components of human, avian, H1N1,
and swine influenza. All spread has been human to human, and spread
appears to be limited; no further cases have been identified in the
last week. None of the cases have had any animal exposure. Because the
virus is unique, IDPH has increased surveillance for this strain at
clinics and emergency rooms.

"It appears the seasonal influenza vaccine currently available may
offer some protection against this novel strain," said IDPH Medical
Director, Dr Patricia Quinlisk. "However, we continue to stress the
importance of personal protective actions. Remember the 3 Cs: Clean
you hands frequently; Cover your coughs and sneezes; and Contain germs
by staying home when ill."

No serious illness or death has been reported in connection with this
novel influenza A/H3N2 virus, and all cases have recovered.

--
Communicated by:
ProMED-mail


[The cases in Iowa differ from the previous cases in other states in
that the infection has been transmitted from human to human. The
majority of cases of infection with this virus have been children. It
is unclear whether the 3 children, resident in the adjacent counties
of Webster and Hamilton, had direct personal contact. If these
children had been vaccinated with the current seasonal influenza
vaccine, it is unlikely that that this vaccine would be generally
protective against this viral infection, contrary to the IDPH
statement.

The state of Iowa can be located on the HealthMap/ProMED-mail
interactive map at http://healthmap.org/r/1sHw. A map showing the
locations of Webster and Hamilton counties in central Iowa can be
accessed at http://www.digital-topo-maps.com/county-map/iowa.shtml.
- Mod.CP]


See Also

Influenza (68): Hong Kong swine-origin H3N2 reassortant
20111119.3411
Influenza (66): USA swine-origin H3N2 reassortant, update
20111105.3298
Influenza (63): USA (ME, NOT NH) swine-origin H3N2 reassortant
20111102.3260
Influenza (60): USA (ME) swine-origin H3N2 reassortant 20111021.3134
Influenza (54): (PA) swine-origin H3N2 reassortant, comment
20110913.2789
Influenza (52): (PA), swine-origin H3N2 reassortant, 3 cases
20110906.2723
Influenza (51): swine-origin H3N2 reassortant, children 20110902.2685
Influenza (40): H3N2/H1N1 reassortant ex patient 20110609.1749]
.................................................cp/mj/lm

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