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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 1:33 pm 
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http://www.recombinomics.com/News/10211 ... roMED.html

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 2:30 pm 
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niman wrote:
niman wrote:
One case of human infection with a novel influenza A virus was reported by the Maine Center for Disease Control and Prevention. The patient was infected with a swine origin influenza A (H3N2) virus. Testing performed at Maine’s Health and Environmental Testing Laboratory on October 14, 2011 indicated a likely swine origin influenza A (H3N2) virus and this result was confirmed at CDC on October 16, 2011. The patient reported attendance at an event where pigs were present in the week preceding symptom onset on October 7, 2011, did not require hospitalization, and continues to recover. No illness has been identified in family members or close contacts, but the investigation is ongoing.

Swine-origin triple reassortant Influenza A (H3N2) viruses have been circulating among North American swine herds since the late 1990's. Human infections with these viruses are detected sporadically, and cases usually occur following direct or indirect contact with pigs. Thirteen human cases of swine-origin influenza A (H3N2) have been reported to CDC since 2005, including five this year. No epidemiologic link has been identified between the case in Maine and recent cases reported in Indiana and Pennsylvania. General information about swine influenza is available at

Note that CDC confirmed positive on Oct 16 and published sequences on Oct 17 at GISAID.

It is also worth noting that the CDC has released H3N2 sequences from 15 US cases collected since July 2011, and 5 of the 15 have been trH3N2.

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 3:53 pm 
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http://www.recombinomics.com/News/10211 ... E_H2H.html

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 4:25 pm 
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CDC Confirms 5th Case of New Swine-Origin H3N2 Reassortant in Maine


October 21, 2011 – – CDC has confirmed the fifth case of human infection with a swine–origin influenza A (H3N2) virus that carries the M gene from the 2009 H1N1 virus. This virus was first detected in a child in Indiana in July. Subsequently three additional cases of human infection with swine–origin influenza A (H3N2) viruses carrying the same genetic change were detected in Pennsylvania. Though rare, human infections with swine–origin influenza viruses can occur, usually after close contact with infected swine. The patient in Maine was reported to have attended an agricultural fair where animals, including pigs, were present. The child was not hospitalized. He received antiviral treatment and is recovering from his illness. Though an investigation is ongoing and surveillance for influenza–like–illness is being enhanced, no human–to–human transmission of this virus has been identified in Maine.

The patient had not received a seasonal influenza vaccination. However it should be noted that seasonal influenza vaccine would NOT be expected to protect against this swine–origin influenza virus because it is so different from the human viruses in the seasonal vaccine. Seasonal influenza vaccination is important to decrease the risk of getting infected with human seasonal influenza viruses, which are beginning to circulate in the United States for the 2011–2012 season.

While there is not a vaccine to protect humans against these swine–origin influenza viruses, there are two FDA–cleared drugs that can be used to treat illness with these viruses. The antiviral drugs oseltamivir and zanamivir – which are used to treat infection with human seasonal viruses – also have shown activity against swine–origin viruses.

Background
On October 14, 2011, CDC received a report from the state of Maine that an influenza virus specimen had tested positive for a likely swine influenza A (H3N2). CDC laboratory testing confirmed a case of human infection with swine–origin influenza A (H3N2) virus. This case brings the total number of confirmed cases of human infection with swine–origin influenza A viruses in the United States to 26 since 2005, with 13 of these having been infected with swine–origin influenza A (H3N2) viruses and five of these being the H3N2 virus with the M gene from the 2009 H1N1 virus.
Pigs can become infected with and spread influenza viruses, including swine, human and avian influenza viruses. Swine influenza A (H3N2) viruses normally infect pigs, but on rare occasions, can also infect humans. Human infection with swine–origin virus is mostly likely to occur when people are in close proximity to infected pigs. Ill pigs infected with flu viruses may exhibit signs similar to human influenza infections, such as coughing (barking), lack of appetite, runny nose and lethargy.

The acquisition of the M gene likely occurred as a result of swine being co–infected with the swine influenza A (H3N2) virus and the human 2009 H1N1 virus. (A visual interpretation of this reassortant process is available at http://www.cdc.gov/media/haveyouheard/s ... igimg.html.) While we know the M gene plays a role in influenza virus infection, assembly and replication, the significance of this change in these swine–origin influenza A (H3N2) viruses is unknown at this time. CDC continues to investigate the implications of this genetic change.
More information about this case is available from the Maine Center for Disease Control & Prevention (Maine CDC) Health Alert Network System (HAN).
More information on swine influenza viruses is available at http://www.cdc.gov/flu/swineflu/.

http://www.cdc.gov/media/haveyouheard/s ... virus.html

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 4:53 pm 
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niman wrote:
CDC Confirms 5th Case of New Swine-Origin H3N2 Reassortant in Maine


October 21, 2011 – – CDC has confirmed the fifth case of human infection with a swine–origin influenza A (H3N2) virus that carries the M gene from the 2009 H1N1 virus. This virus was first detected in a child in Indiana in July.

While we know the M gene plays a role in influenza virus infection, assembly and replication, the significance of this change in these swine–origin influenza A (H3N2) viruses is unknown at this time.

The CDC is clearly in a state of denial with regard to human transmission. The M gene was deemed "critical" for human to human transmission of pandemic H1N1, and now it is 5 of 5 2011 trH3N2 cases.

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 4:57 pm 
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New Hampshire residents who work with pigs are being cautioned to keep an eye out for flu-like symptoms after a Maine child became sick from “novel influenza virus” following contact with pigs, “including time spent in a closed setting at an agricultural fair.”

The child became sick earlier this month. So far, officials said Friday, the case of the child in Cumberland County, Maine, “is an isolated event.” Importantly, Maine “is not aware of any person-to-person transmission.”

Public health officials have long feared fear that a new, dangerous strain of influenza would be bred in animals and passed to people, where it would have the ability to spread throughout the human population in a manner similar to the devastating 1918 influenza pandemic.

That concern explains the enormous publicity and reaction to the so-called “swine flu” scare of 2009, which petered out when the H1N1 strain proved less dangerous than feared.

Maine Center for Disease Control and Prevention and federal health authorities are investigation the latest case, which is unusual although not unique. Since 2005, the federal CDC reports, there have been 26 cases of flu virus passing from pigs to people.

None of those cases have resulted in disease that passes among people.

“Swine-origin influenza is rare in humans, but veterinarians should remind owners and those who work closely with swine to watch for symptoms of ILI (influenza-like illness) in themselves and their families. Any person with ILI, defined as fever greater than 100 degree with cough or sore throat, should contact their primary care provider for follow up,” said the announcement from Maine, which was passed on to New Hampshire veterinarians Thursday.

Influenza can have a variety of signatures, differentiated by the letters H and N, which stand for different proteins on the surface of the virus. There are 16 types of H (hemagglutinin) and nine types of N (neuramidinase), meaning up to 1454 different strains of flu can exist, which is why tracking and vaccinating for the disease is difficult.

Officials said the influenza in the Maine case “is similar to rare human infections with swine-origin H3N2 viruses, but it also contains a genetic component of the pandemic H1N1 virus. This is genetically similar to four previous cases identified in the United States this year, three in Pennsylvania and one in Indiana, all of which had exposure to swine.”

– DAVID BROOKS

http://www.nashuatelegraph.com/newsstat ... asses.html

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 4:59 pm 
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niman wrote:
Maine Center for Disease Control and Prevention and federal health authorities are investigation the latest case, which is unusual although not unique. Since 2005, the federal CDC reports, there have been 26 cases of flu virus passing from pigs to people.

None of those cases have resulted in disease that passes among people.

– DAVID BROOKS

http://www.nashuatelegraph.com/newsstat ... asses.html

More media myth

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 5:02 pm 
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PORTLAND, Maine — Maine health officials are investigating a case of a young boy coming down with what is being described as an unusual strain of influenza.

The Maine Center for Disease Control and Prevention says the 7- or 8-year-old boy from Cumberland County came down with flu-like symptoms in early October, not long after being exposed to pigs at an agricultural fair.

State Epidemiologist Stephen Sears says the H3N2 swine-origin strain of influenza was confirmed by the U.S. Centers for Disease Control as genetically similar to a strain identified in three cases in Pennsylvania and one case in Indiana.

Sears said the boy was treated by his family doctor and is back up and playing. He said health experts don't expect the new strain to pose a widespread threat.

http://www.therepublic.com/view/story/7 ... lu-Strain/

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 5:06 pm 
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niman wrote:
PORTLAND, Maine —
The Maine Center for Disease Control and Prevention says the 7- or 8-year-old boy from Cumberland County came down with flu-like symptoms in early October, not long after being exposed to pigs at an agricultural fair.

http://www.therepublic.com/view/story/7 ... lu-Strain/

The name of the file for the above story indcates the chld was a 7 year old girl. It is not clear where this misinformation began. The CDC released sequences on Monday and the associated characterization sheet said 8 year old male.

One blog was talking anout a 7 year old girl from Cumberland County, Maryland in conjunction with the Maine case, which may have been the source of the misinformation.

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 Post subject: Re: trH3N2 Case In Maine
PostPosted: Fri Oct 21, 2011 5:09 pm 
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niman wrote:
niman wrote:
PORTLAND, Maine —
The Maine Center for Disease Control and Prevention says the 7- or 8-year-old boy from Cumberland County came down with flu-like symptoms in early October, not long after being exposed to pigs at an agricultural fair.

http://www.therepublic.com/view/story/7 ... lu-Strain/

The name of the file for the above story indcates the chld was a 7 year old girl. It is not clear where this misinformation began. The CDC released sequences on Monday and the associated characterization sheet said 8 year old male.

One blog was talking anout a 7 year old girl from Cumberland County, Maryland in conjunction with the Maine case, which may have been the source of the misinformation.

Novel H3N2 flu virus infects child in Maine
Posted on October 21, 2011 by monotreme1000
A 7 year old girl in Cumberland County Maryland has been infected with the same H3N2 influenza virus that has previously infected three people in Pennsylvania and one in Indiana. This virus is apparently circulating in pigs in the US.

The people in Indiana and Pennsylvania were infected in August 2011. The 7 year old girl in Maryland became ill in early October 2011. She is reported to have been in close proximity to pigs at an agricultural fair. There is disagreement regarding the severity of her symptoms. Although most reports suggest that she was not hospitalised, one media source says that she was.

http://monotreme1000.wordpress.com/2011 ... -in-maine/

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