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PostPosted: Mon Sep 12, 2011 5:07 am 
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niman wrote:
2 cases of new swine flu viruses reported
By: Tammie Smith
Published: September 12, 2011
A few days later, Pennsylvania health officials reported that they had identified two additional children in that state with the new swine flu virus, and that all three children had attended an agricultural fair in southwestern Pennsylvania during the week of Aug. 13-20.

The Indiana case was not linked to the others, and the flu-virus strain was slightly different. A person taking care of the child did report contact with pigs in the weeks before the child started showing flu symptoms.

http://www2.timesdispatch.com/lifestyle ... r-1301977/

The above answer in a Q&A published today demonstrates the confusion caused by the CDC report. The isolate from the Schuylkill patient, A/Pennsylvania/09/2011, was a drift variant of the isolate from Indiana, A/Indiana/08/2011, but the two isolates from Washington County (A/Pennsylvania/10/2011 and A/Pennsylvania/11/2011) were virtually identical to two INDIANA isolates (from samples collected July 24 and 27).

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PostPosted: Mon Sep 12, 2011 5:26 am 
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Location: Pittsburgh, PA USA
niman wrote:
niman wrote:
2 cases of new swine flu viruses reported
By: Tammie Smith
Published: September 12, 2011
A few days later, Pennsylvania health officials reported that they had identified two additional children in that state with the new swine flu virus, and that all three children had attended an agricultural fair in southwestern Pennsylvania during the week of Aug. 13-20.

The Indiana case was not linked to the others, and the flu-virus strain was slightly different. A person taking care of the child did report contact with pigs in the weeks before the child started showing flu symptoms.

http://www2.timesdispatch.com/lifestyle ... r-1301977/

The above answer in a Q&A published today demonstrates the confusion caused by the CDC report. The isolate from the Schuylkill patient, A/Pennsylvania/09/2011, was a drift variant of the isolate from Indiana, A/Indiana/08/2011, but the two isolates from Washington County (A/Pennsylvania/10/2011 and A/Pennsylvania/11/2011) were virtually identical to two INDIANA isolates (from samples collected July 24 and 27).

The confusion created by the CDC release on the IN and PA cases is similar to the confusion created by the WHO pager alert almost a year ago. That alert described two trH3N2 isolates, A/Wisconsin/12/2010 and A/Pennsylvania/14/2010 that were isolated 6 weeks apart and were somewhat different (especially in NA), indicating they did not come from a common source. However, a second PA isolate, A/Pennsylvania/40/2010 was reported in 2011. It had been isolated from a patient who developed symptoms a few days prior to teh Wisconsin cases, and the sequences between WI/12/10 and PA/40/10 were virtually identical, signaling a common source, even though the patients were not epidemiologocally linked and live 100's of miles apart. the same trH3N2 was subsequnely isolated from a cluster in Minnesota (A/Minnesota/11/2010) and that H3 and N2 were used to make a pandemic trH3N2 vaccine target.

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PostPosted: Mon Sep 12, 2011 6:29 am 
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http://www.recombinomics.com/News/09121 ... M_Seq.html

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PostPosted: Mon Sep 12, 2011 7:58 am 
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http://www.recombinomics.com/News/09121 ... ntact.html

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PostPosted: Mon Sep 12, 2011 10:55 am 
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http://www.recombinomics.com/News/09121 ... cords.html

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PostPosted: Mon Sep 12, 2011 11:37 am 
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HICAGO - Two U.S. children were infected with flu viruses that originated in pigs in the past two months, and an analysis of both viruses showed they had picked up genetic material from the 2009 pandemic influenza A H1N1 virus, government researchers said on Friday.

They issued a warning to health workers to watch out for suspect viruses because those that cross between species can be especially virulent.

In both children, one from Indiana and one from Pennsylvania, an analysis of the viruses showed they contained a gene of the 2009 pandemic flu virus, according to a report released by the U.S. Centers for Disease Control and Prevention.

Flu viruses that jump from one species to another are a concern because they can swap genes and form an entirely new virus, making them harder to protect against.

"Pandemic viruses get started when they reassort and they emerge as a new virus. That is why we have to keep close watch on new influenza viruses as they emerge," CDC spokesman Tom Skinner said.

"They are constantly changing, and that is why we have to have really good surveillance systems in place to detect them when they do emerge," he said. So far, this new virus does not appear to be able to easily pass from human to human, but Skinner said the CDC is still investigating.

Since 2005, there have been about 22 cases of human infection from swine-origin influenza viruses similar to the cases now being reported, Skinner said. All 22 people have recovered.

In one of the two new cases, a young boy from Indiana who had gotten a flu vaccine last September developed fever, cough, shortness of breath, diarrhea and a sore throat in late July. He was taken to the emergency department and a swab of his throat indicated that he had been infected by an influenza A virus.

The boy was sent home untreated but returned to the hospital the next day to be admitted and treated for multiple chronic health conditions, which had gotten worse because of his infection.

The boy recovered and was sent home, but further testing by state officials suggested his virus had originated in pigs, and his sample was sent to the CDC for confirmation.

According to the CDC report, the child had no prior direct contact with pigs, but a child-care worker who looked after the boy did report having contact with pigs before the child's symptoms appeared.

In the second case, a Pennsylvania girl under age 5 who had received a flu shot the prior year developed a suspected infection with swine-origin influenza A (H3N2) in August.

Later testing by state officials and the CDC confirmed that she, too, had developed a form of flu that originated in pigs, likely from direct contact at an agricultural fair.

The girl was not treated and has completely recovered.

So far, the CDC has not seen any additional cases of people developing a pig form of influenza, but Skinner said the CDC is publishing the report to remind doctors and health workers to be watchful for suspicious cases of flu.

The H1N1 pandemic flu strain was discovered in Mexico and the United States in March 2009 and spread rapidly across the world. The World Health Organization estimates about 18,450 people died from the virus up to August 2010, including many pregnant women and young people.

Seasonal flu vaccines being offered across the world protect against the H1N1 strain. Flu vaccines are made by several drugmakers including Glaxosmithkline, Sanofi and Novartis.



Read more: http://www.canada.com/health/children+d ... z1XkjibSNg

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PostPosted: Tue Sep 13, 2011 12:49 pm 
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Three children were infected with a novel influenza A virus after visiting an agricultural fair in southwestern Pennselvania, but state and local health officials don't fear that it's the start of a major outbreak.

"Everything that has come out so far suggests these are not easily transmittable," said Dr. Robert S. Jones, chief of infectious diseases at both St. Joseph Medical Center and Reading Hospital. "People shouldn't panic about that strain."

The Pennsylvania departments of health and agriculture announced the cases last week and said all three children attended the Washington County Agricultural Fair the week of Aug. 13-20.

The cases are similar to previous, rare human infections with swine-origin H3N2 viruses, but they are unique in that they contain a genetic component of the 2009 H1N1 virus that was involved in a pandemic.

An investigation has not yet uncovered how the illness was transmitted.

This year's flu vaccine does not protect against this novel strain, state health officials said.

But the strain does respond to treatment with the antiviral drugs oseltamivir and zanamivir, which are used to treat infection with human seasonal viruses.

"Currently, we don't have any evidence to support that this novel influenza A virus will lead to a pandemic, as we haven't yet been able to prove that it is being transmitted from human to human," state health officials said in a statement.

The state Health Department and the federal Centers for Disease Control are conducting increased surveillance and tracking in southwestern Pennsylvania.

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