Rhiza Labs FluTracker Forum
http://fluboard.rhizalabs.com/forum/

trH3N2 In Pennsylvania and Indiana Match
http://fluboard.rhizalabs.com/forum/viewtopic.php?f=5&t=7453
Page 2 of 9

Author:  niman [ Fri Sep 02, 2011 10:51 pm ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

niman wrote:
Novel Influenza A Virus:
These viruses are genetically related, but different enough to suggest there was not a common source of infection. No epidemiologic link between these two cases has been identified.
http://www.cdc.gov/flu/weekly/

The sequence of A/Indiana/18/2011 is public. The PA sequence is not. The Indian sequence is the only known sequence with trH3N2 with MP pandemic H1N1. The H3 of swine isolates from Indiana and North Carolina is very closely related to the human case, but the swine isolates have a trH3N2 MP. The fact that both human isolates have pandemic H1N1 MP signals transmission. the above differences raise concerns that this novel constellation is widespread in humans.

Author:  niman [ Fri Sep 02, 2011 11:13 pm ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

niman wrote:
niman wrote:
Novel Influenza A Virus:
These viruses are genetically related, but different enough to suggest there was not a common source of infection. No epidemiologic link between these two cases has been identified.
http://www.cdc.gov/flu/weekly/

The sequence of A/Indiana/18/2011 is public. The PA sequence is not. The Indian sequence is the only known sequence with trH3N2 with MP pandemic H1N1. The H3 of swine isolates from Indiana and North Carolina is very closely related to the human case, but the swine isolates have a trH3N2 MP. The fact that both human isolates have pandemic H1N1 MP signals transmission. the above differences raise concerns that this novel constellation is widespread in humans.

Top 100 HA matches at GISAID:
EPI333152 A/Indiana/08/2011 (A/H3N2) segment 4 (HA) 3142.3 0.000000e+00 1701/1701 (100%)
EPI324857 A/swine/North Carolina/A01049436/2011 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI317003 A/swine/Indiana/A0109091/2010 (A/H3N2) segment 4 (HA) 3098.0 0.000000e+00 1693/1701 (99%)
EPI293965 A/Minnesota/11/2010 (A/H3N2) segment 4 (HA) 3081.3 0.000000e+00 1690/1701 (99%)
EPI291898 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 3075.8 0.000000e+00 1689/1701 (99%)
EPI328900 A/Minnesota/11/2010 X-203A (A/H3N2) segment 4 (HA) 3070.3 0.000000e+00 1688/1701 (99%)
EPI312980 A/Pennsylvania/40/2010 (A/H3N2) segment 4 (HA) 3070.3 0.000000e+00 1688/1701 (99%)
EPI328898 A/Minnesota/11/2010 X-203 (A/H3N2) segment 4 (HA) 3064.7 0.000000e+00 1687/1701 (99%)
EPI291838 A/Minnesota/09/2010 (A/H3N2) segment 4 (HA) 2996.4 0.000000e+00 1658/1676 (98%)
EPI291893 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 2922.5 0.000000e+00 1606/1618 (99%)
EPI222910 A/swine/Minnesota/7931/2007 (A/H3N2) segment 4 (HA) 2881.9 0.000000e+00 1656/1703 (97%)
EPI314335 A/turkey/BC/1529-3/2005 (A/H3N2) segment 4 (HA) 2854.2 0.000000e+00 1651/1703 (96%)
EPI103199 A/swine/Ontario/33853/2005 (A/H3N2) segment 4 (HA) 2854.2 0.000000e+00 1651/1703 (96%)
EPI103127 A/Ontario/RV1273/2005 (A/H3N2) segment 4 (HA) 2854.2 0.000000e+00 1651/1703 (96%)
EPI229372 A/turkey/OH/313053/2004 (A/H3N2) segment 4 (HA) 2848.7 0.000000e+00 1650/1703 (96%)
EPI103181 A/swine/Manitoba/12707/2005 (A/H3N2) segment 4 (HA) 2843.1 0.000000e+00 1649/1703 (96%)
EPI103145 A/swine/Alberta/14722/2005 (A/H3N2) segment 4 (HA) 2843.1 0.000000e+00 1649/1703 (96%)
EPI101389 A/turkey/Ohio/313053/04 (A/H3N2) segment 4 (HA) 2843.1 0.000000e+00 1649/1703 (96%)
EPI289638 A/swine/Minnesota/1300/2007 (A/H3N2) segment 4 (HA) 2832.0 0.000000e+00 1647/1703 (96%)
EPI158876 A/turkey/MN/366767/2005 (A/H3N2) segment 4 (HA) 2832.0 0.000000e+00 1647/1703 (96%)
EPI228922 A/turkey/Illinois/2004 (A/H3N2) segment 4 (HA) 2815.4 0.000000e+00 1645/1704 (96%)
EPI168645 A/turkey/Minnesota/366767/2005 (A/H3N2) segment 4 (HA) 2815.4 0.000000e+00 1645/1704 (96%)
EPI103217 A/turkey/Ontario/31232/2005 (A/H3N2) segment 4 (HA) 2815.4 0.000000e+00 1645/1704 (96%)
EPI227574 A/turkey/NC/353568/2005 (A/H3N2) segment 4 (HA) 2804.3 0.000000e+00 1642/1703 (96%)
EPI168650 A/turkey/North Carolina/353568/2005 (A/H3N2) segment 4 (HA) 2804.3 0.000000e+00 1642/1703 (96%)
EPI166252 A/swine/Minnesota/SG-00234/2005 (A/H3N2) segment 4 (HA) 2796.9 0.000000e+00 1633/1691 (96%)
EPI225756 A/swine/Minnesota/66853/2006 (A/H3N2) segment 4 (HA) 2793.3 0.000000e+00 1640/1703 (96%)
EPI98712 A/swine/MI/PU243/04 (A/H3N1) segment 4 (HA) 2789.6 0.000000e+00 1638/1702 (96%)
EPI182817 A/swine/Quebec/4001/2005 (A/H3N2) segment 4 (HA) 2787.7 0.000000e+00 1639/1703 (96%)
EPI222756 A/swine/Minnesota/1145/2007 (A/H3N2) segment 4 (HA) 2782.2 0.000000e+00 1638/1703 (96%)
EPI128344 A/Ontario/1252/2007 (A/H3N2) segment 4 (HA) 2782.2 0.000000e+00 1638/1703 (96%)
EPI103163 A/swine/British Columbia/28103/2005 (A/H3N2) segment 4 (HA) 2782.2 0.000000e+00 1639/1704 (96%)
EPI166255 A/swine/Minnesota/SG-00235/2007 (A/H3N2) segment 4 (HA) 2780.3 0.000000e+00 1630/1691 (96%)
EPI166258 A/swine/Minnesota/SG-00236/2007 (A/H3N2) segment 4 (HA) 2778.5 0.000000e+00 1629/1690 (96%)
EPI225758 A/swine/Minnesota/66960/2006 (A/H3N2) segment 4 (HA) 2776.6 0.000000e+00 1637/1703 (96%)
EPI222674 A/swine/Oklahoma/008722/2007 (A/H3N2) segment 4 (HA) 2776.6 0.000000e+00 1637/1703 (96%)
EPI184448 A/swine/North Carolina/R08-001877-D08-013371/2008 (A/H3N2) segment 4 (HA) 2776.6 0.000000e+00 1638/1704 (96%)
EPI314635 A/swine/QC/2108-2/2009 (A/H3N2) segment 4 (HA) 2771.1 0.000000e+00 1636/1703 (96%)
EPI225753 A/swine/Minnesota/65767/2006 (A/H3N2) segment 4 (HA) 2771.1 0.000000e+00 1636/1703 (96%)
EPI222959 A/swine/Minnesota/578/2007 (A/H3N2) segment 4 (HA) 2771.1 0.000000e+00 1637/1704 (96%)
EPI222657 A/swine/Minnesota/5947/2007 (A/H3N2) segment 4 (HA) 2765.6 0.000000e+00 1635/1703 (96%)
EPI166278 A/swine/Minnesota/SG-00242/2006 (A/H3N2) segment 4 (HA) 2765.6 0.000000e+00 1629/1694 (96%)
EPI309154 A/swine/Pennsylvania/62170-3/2010 (A/H3N2) segment 4 (HA) 2760.0 0.000000e+00 1633/1702 (95%)
EPI309153 A/swine/Pennsylvania/62170-1/2010 (A/H3N2) segment 4 (HA) 2760.0 0.000000e+00 1633/1702 (95%)
EPI259504 A/swine/Minnesota/03008/2010 (A/H3N2) segment 4 (HA) 2754.5 0.000000e+00 1634/1704 (95%)
EPI222961 A/swine/Minnesota/761/2007 (A/H3N2) segment 4 (HA) 2754.5 0.000000e+00 1634/1704 (95%)
EPI182824 A/mink/Nova Scotia/1055488/2007 (A/H3N2) segment 4 (HA) 2754.5 0.000000e+00 1633/1703 (95%)
EPI314679 A/swine/QC/414/2009 (A/H3N2) segment 4 (HA) 2750.8 0.000000e+00 1634/1704 (95%)
EPI317007 A/swine/Iowa/A0109112/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1634/1705 (95%)
EPI291872 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1631/1702 (95%)
EPI291870 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1631/1702 (95%)
EPI291865 A/Pennsylvania/14/2010 (A/H3N2) segment 4 (HA) 2748.9 0.000000e+00 1631/1702 (95%)
EPI318106 A/swine/Iowa/A01049185/2010 (A/H3N2) segment 4 (HA) 2743.4 0.000000e+00 1632/1704 (95%)
EPI318095 A/swine/Iowa/A01049113/2010 (A/H3N2) segment 4 (HA) 2743.4 0.000000e+00 1633/1705 (95%)
EPI312689 A/swine/Minnesota/239105/2009 (A/H3N2) segment 4 (HA) 2743.4 0.000000e+00 1629/1701 (95%)
EPI324844 A/swine/Nebraska/A01049235/2010 (A/H3N2) segment 4 (HA) 2737.9 0.000000e+00 1632/1705 (95%)
EPI314796 A/swine/Pennsylvania/602170-4/2010 (A/H3N2) segment 4 (HA) 2737.9 0.000000e+00 1629/1702 (95%)
EPI222682 A/swine/Oklahoma/011506/2007 (A/H3N2) segment 4 (HA) 2737.9 0.000000e+00 1630/1703 (95%)
EPI324851 A/swine/Iowa/A01049317/2010 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1629/1704 (95%)
EPI324849 A/swine/Iowa/A01049254/2010 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1628/1703 (95%)
EPI314666 A/swine/QC/1698-2/2009 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1629/1704 (95%)
EPI314665 A/swine/QC/1698-1/2009 (A/H3N2) segment 4 (HA) 2726.8 0.000000e+00 1629/1704 (95%)
EPI314667 A/swine/QC/1698-4/2009 (A/H3N2) segment 4 (HA) 2721.2 0.000000e+00 1628/1704 (95%)
EPI314643 A/swine/QC/382/2009 (A/H3N2) segment 4 (HA) 2721.2 0.000000e+00 1627/1703 (95%)
EPI316991 A/swine/Iowa/A0109035/2010 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1624/1701 (95%)
EPI316990 A/swine/Iowa/A0109034/2010 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1624/1701 (95%)
EPI314668 A/swine/QC/1698-5/2009 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1627/1704 (95%)
EPI307943 A/swine/Iowa/A01057188/2010 (A/H3N2) segment 4 (HA) 2715.7 0.000000e+00 1628/1705 (95%)
EPI314795 A/swine/Pennsylvania/602170-2/2010 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1624/1702 (95%)
EPI302647 A/swine/Illinois/53612-2/2009 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1626/1704 (95%)
EPI302646 A/swine/Illinois/53612-1/2009 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1626/1704 (95%)
EPI244297 A/Kansas/13/2009 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1626/1704 (95%)
EPI25393 A/turkey/ Minnesota/764-2/03 (A/H3N2) segment 4 (HA) 2710.2 0.000000e+00 1627/1705 (95%)
EPI314687 A/swine/QC/1840-2/2009 (A/H3N2) segment 4 (HA) 2706.5 0.000000e+00 1623/1701 (95%)
EPI314663 A/swine/QC/1685-1/2009 (A/H3N2) segment 4 (HA) 2704.6 0.000000e+00 1624/1703 (95%)
EPI230035 A/swine/Wisconsin/R7c/2001 (A/H3N2) segment 4 (HA) 2704.6 0.000000e+00 1626/1705 (95%)
EPI25391 A/turkey/North Carolina/12344/03 (A/H3N2) segment 4 (HA) 2704.6 0.000000e+00 1626/1705 (95%)
EPI314695 A/swine/QC/440-A/2009 (A/H3N2) segment 4 (HA) 2695.4 0.000000e+00 1625/1706 (95%)
EPI314664 A/swine/QC/1685-5/2009 (A/H3N2) segment 4 (HA) 2693.5 0.000000e+00 1622/1703 (95%)
EPI219360 A/swine/Kansas/015252/2009 (A/H3N2) segment 4 (HA) 2693.5 0.000000e+00 1622/1703 (95%)
EPI314515 A/quail/QC/FAV-10/2008 (A/H3N2) segment 4 (HA) 2688.0 0.000000e+00 1620/1702 (95%)
EPI324850 A/swine/Pennsylvania/A01049256/2010 (A/H3N2) segment 4 (HA) 2684.3 0.000000e+00 1622/1705 (95%)
EPI292016 A/swine/Iowa/H03BF5/2003 (A/H3N2) segment 4 (HA) 2678.8 0.000000e+00 1623/1707 (95%)
EPI324852 A/swine/Minnesota/A01049346/2010 (A/H3N2) segment 4 (HA) 2676.9 0.000000e+00 1620/1704 (95%)
EPI307945 A/swine/Illinois/A01057088/2010 (A/H3N2) segment 4 (HA) 2676.9 0.000000e+00 1622/1706 (95%)
EPI302658 A/swine/Illinois/53612-5/2009 (A/H3N2) segment 4 (HA) 2676.9 0.000000e+00 1621/1705 (95%)
EPI318101 A/swine/Iowa/A01049160/2010 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1622/1707 (95%)
EPI307944 A/swine/Illinois/A01057087/2010 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1621/1706 (95%)
EPI302653 A/swine/Illinois/53612-4/2009 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1620/1705 (95%)
EPI219368 A/swine/Oklahoma/001142/2009 (A/H3N2) segment 4 (HA) 2671.4 0.000000e+00 1618/1703 (95%)
EPI98686 A/swine/Minnesota/00395/2004 (A/H3N1) segment 4 (HA) 2665.8 0.000000e+00 1619/1705 (94%)
EPI314161 A/swine/Quebec/1265553/2010 (A/H3N2) segment 4 (HA) 2660.3 0.000000e+00 1611/1695 (95%)
EPI302664 A/swine/Illinois/53612-7/2010 (A/H3N2) segment 4 (HA) 2660.3 0.000000e+00 1619/1706 (94%)
EPI302659 A/swine/Illinois/53612-6/2010 (A/H3N2) segment 4 (HA) 2660.3 0.000000e+00 1618/1705 (94%)
EPI316988 A/swine/Iowa/A0109031/2010 (A/H3N2) segment 4 (HA) 2654.8 0.000000e+00 1618/1706 (94%)
EPI316989 A/swine/Iowa/A0109032/2010 (A/H3N2) segment 4 (HA) 2651.1 0.000000e+00 1617/1706 (94%)
EPI318097 A/swine/Indiana/A01049124/2010 (A/H3N2) segment 4 (HA) 2632.6 0.000000e+00 1614/1706 (94%)
EPI131612 A/swine/Wisconsin/H03HO7/2003 (A/H3N2) segment 4 (HA) 2632.6 0.000000e+00 1614/1706 (94%)
EPI161141 A/Hong Kong/CUHK4147/1997 (A/H3N2) segment 4 (HA) 2621.5 0.000000e+00 1613/1707 (94%)
EPI98728 A/swine/IN/PU542/04 (A/H3N1) segment 4 (HA) 2621.5 0.000000e+00 1612/1706 (94%)

Author:  niman [ Fri Sep 02, 2011 11:18 pm ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

CDC has linked MMWR early release to its SOIV website

http://www.cdc.gov/flu/swineflu/soiv_cases.htm

Author:  niman [ Sat Sep 03, 2011 3:14 am ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

'Swine flu' detected in Indiana boy
Rare virus is no cause for alarm, state health official says
12:29 AM, Sep. 3, 2011 A new strain of "swine flu" has shown up in two young children in Pennsylvania and Indiana who had direct or indirect contact with pigs.

So far, there's no sign the virus has spread beyond the two cases, the Centers for Disease Control and Prevention reported Friday.

"We wanted to provide some information without being alarmist," because people have contact with pigs at fairs this time of year and doctors should watch for possible flu cases, said Lyn Finelli, the CDC's flu surveillance chief. "We're always concerned when we see transmission of animal viruses to humans."

People rarely get flu from pigs -- only 21 cases have been documented in the past five years -- and it's too soon to know how infectious this virus will be, Finelli said.

This particular virus has only been seen eight times in the past five years -- the Indiana case was the ninth and the Pennsylvania case the 10th, according to the CDC's Morbidity and Mortality Weekly Report on Friday.

In Indiana, the virus was picked up as part of routine flu surveillance, said Shawn Richards, respiratory epidemiologist for the Indiana State Department of Health.

A boy younger than 5, who had chronic health problems, went to the hospital with flu symptoms on July 23. Richards declined to say where the case occurred.

When the boy's flu test came back positive, the state's virology lab requested the specimen, as it's unusual to see the disease at this time of year, Richards said. The lab found the flu strain to be nonhuman and sent it to the CDC.

The boy had had no contact with pigs, but a caretaker did in the weeks before he fell ill. She was asymptomatic, Richards said. No other family members appear ill.

In the Pennsylvania case, a girl, also younger than 5, had contact with pigs at an agricultural fair last month. She, too, has recovered, and health officials are investigating reports of illness in other people who went to the fair. No additional cases have been confirmed so far.

The viruses in the two children were similar but not identical, and Richards said there was no indication of a connection between the two cases.

Despite the rarity of such cases, there's no reason for alarm, health officials say.

"It's more of an intriguing, interesting thing," Richard said. "What it has told us is that our surveillance systems are working very well."

Studies showed that the virus includes a gene from the 2009 pandemic strain that might let it spread more easily than pig viruses normally do.

The new strain is a hybrid of viruses that have infected pigs over the past decade and a gene from the H1N1 strain that caused the pandemic two years ago. It is the first combination virus to turn up in people since the pandemic, said Michael Shaw, a lab chief at the CDC. It's classified as an H3N2 virus.

The gene from the 2009 pandemic is one of the things that makes this new strain worrisome, said Dr. John Treanor, a flu specialist at the University of Rochester School of Medicine.

"There is some evidence that that gene is particularly important for transmission from person to person," he said.

This year's vaccine, which is the same as last year's, likely would not protect against the new swine strain, Treanor and Finelli said. However, they are encouraged that so far it does not appear to have spread easily between people, and that local health officials detected and reported the novel strain so quickly.

Star reporter Shari Rudavsky and The Associated Press contributed to this story.

http://www.indystar.com/article/2011090 ... ext%7CNews

Author:  niman [ Sat Sep 03, 2011 3:52 am ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

niman wrote:
CDC has linked MMWR early release to its SOIV website

http://www.cdc.gov/flu/swineflu/soiv_cases.htm

The updated CDC site has strategically ignored the MMWR report on the Minnesota cluster

Reported Human Infections with Swine Origin Influenza Viruses (SOIV) in the United States since 2005
As of January 25, 2011, 20 cases of human infection with swine origin influenza viruses (SOIV) have been reported in the United States. These are viruses that normally infect pigs. Like human influenza viruses, there are different subtypes and strains of swine origin influenza viruses. The main swine viruses circulating in U.S. pigs in recent years are swine triple reassortant (tr) H1N1 influenza virus, trH3N2 virus and trH1N2 virus. Of the 20 human cases reported since 2005, 12 have been trH1N1 viruses, seven have been trH3N2 viruses and one has been a trH1N2 virus. All 20 persons infected with swine viruses recovered from their illness. Thirteen cases occurred in children (persons younger than 19) and 7 cases occurred in adults. In 16 cases, direct or indirect exposure to swine prior to onset of illness has been identified. Although no person-to-person transmission of swine influenza viruses has been laboratory confirmed in the investigation of these cases to date, some cases reported only exposure to ill persons and no exposure to live pigs. Thus, limited person-to-person is likely to have occurred.

Related Links & Past Reports
Swine-Origin Influenza A (H3N2) Virus Infection in Two Children — Indiana and Pennsylvania, July — August 2011. MMWR 2011; 60 (Early Release); 1-4.
Update: Influenza Activity — United States, October 3, 2010-February 5, 2011. MMWR 2011; 60(06):175-181
Update: Influenza Activity — United States, October 3, 2010-December 11, 2010. MMWR 2010; 59(50):1651-1655
December 17, 2010 “Have You Heard”
November 12, 2010 “Have You Heard”
Information about 11 cases occurring between 2005 and 2009 can be found in the New England Journal of Medicine article entitled “Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009” [262 KB, 10 pages]

Author:  niman [ Sat Sep 03, 2011 5:34 am ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

niman wrote:
niman wrote:
CDC has linked MMWR early release to its SOIV website

http://www.cdc.gov/flu/swineflu/soiv_cases.htm

The updated CDC site has strategically ignored the MMWR report on the Minnesota cluster

Reported Human Infections with Swine Origin Influenza Viruses (SOIV) in the United States since 2005
As of January 25, 2011, 20 cases of human infection with swine origin influenza viruses (SOIV) have been reported in the United States. These are viruses that normally infect pigs. Like human influenza viruses, there are different subtypes and strains of swine origin influenza viruses. The main swine viruses circulating in U.S. pigs in recent years are swine triple reassortant (tr) H1N1 influenza virus, trH3N2 virus and trH1N2 virus. Of the 20 human cases reported since 2005, 12 have been trH1N1 viruses, seven have been trH3N2 viruses and one has been a trH1N2 virus. All 20 persons infected with swine viruses recovered from their illness. Thirteen cases occurred in children (persons younger than 19) and 7 cases occurred in adults. In 16 cases, direct or indirect exposure to swine prior to onset of illness has been identified. Although no person-to-person transmission of swine influenza viruses has been laboratory confirmed in the investigation of these cases to date, some cases reported only exposure to ill persons and no exposure to live pigs. Thus, limited person-to-person is likely to have occurred.

Related Links & Past Reports
Swine-Origin Influenza A (H3N2) Virus Infection in Two Children — Indiana and Pennsylvania, July — August 2011. MMWR 2011; 60 (Early Release); 1-4.
Update: Influenza Activity — United States, October 3, 2010-February 5, 2011. MMWR 2011; 60(06):175-181
Update: Influenza Activity — United States, October 3, 2010-December 11, 2010. MMWR 2010; 59(50):1651-1655
December 17, 2010 “Have You Heard”
November 12, 2010 “Have You Heard”
Information about 11 cases occurring between 2005 and 2009 can be found in the New England Journal of Medicine article entitled “Triple-Reassortant Swine Influenza A (H1) in Humans in the United States, 2005–2009” [262 KB, 10 pages]

CDC hiding of Minnesota cluster is being discussed here

viewtopic.php?f=5&t=7459

Author:  niman [ Sat Sep 03, 2011 6:23 am ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

A report released on Friday by the U.S. Centers for Disease Control and Prevention serves as a reminder that pigs can be “mixing vessels” for new flu viruses. Two young children became infected with new versions of flu – luckily, strains that were not especially harmful -- and both recovered.

Both cases are linked to summer agricultural fairs, where swine and other animals are on display and often petted by adults and children, CDC and state health officials said.

What’s unusual about both cases is the type of changes in the virus. Flu viruses have eight genes, and this one is seven-eighths pig virus – a virus designated H3N2 that’s been circulating among swine for years. But one single gene comes from the H1N1 swine flu virus that caused a new pandemic of influenza in 2009 and which is now part of the human seasonal flu mix.

“Although reassortment between swine influenza and 2009 influenza A (H1N1) viruses has been reported in pigs in the United States, this particular genetic combination of swine influenza virus segments is unique and has not been reported previously in either swine or humans,” Scott Epperson at the CDC, along with colleagues there and in Indiana, wrote in the report. “Because these viruses carry a unique combination of genes, no information currently is available regarding the capacity of this virus to transmit efficiently in swine, humans, or between swine and humans.”

Reassortment is a process different from mutation, one in which viruses swap genes or even longer stretches of genetic material. The H1N1 swine flu virus was the result of this kind of swap-out -- a mixture of human, bird and pig viruses that also, luckily, turned out not to be especially deadly although it did at first strike younger, healthier people than are usually made seriously ill by flu.

While the flu vaccine does not protect against a new virus coming straight from pigs to people, the virus can be treated with the two drugs that work against seasonal flu – Tamiflu and Relenza.

But this virus doesn’t look especially dangerous, said CDC flu experts Dr. Lyn Finelli and Dr. Michael Shaw. Both children, under 5, are fine. “They recovered completely and they had very mild illnesses,” Finelli said. “It’s not scary. It is typical of what we see during county fair and agricultural fair season. We always see a few cases of these swine flu reassortants.”

Both children had potential direct or indirect exposure to pigs, Finelli said. One, a girl in Indiana, was cared for by a woman who exhibited pigs at a fair. It’s possible the caregiver had an infection she did not even notice and gave it to the child. The other case, a boy in Pennsylvania, visited a fair where there was a petting zoo and pigs on show.

Finelli said public health labs had the money they need to test for new flu viruses. CDC was urging doctors to keep an eye out for unusual types of flu and to ask patients with flu-like symptoms if they have been to a fair or been around pigs.

Pigs can catch human flu easily, and vice-versa. Shaw noted that pigs were more likely to catch H1N1 from people than the other way around.

http://www.nationaljournal.com/healthca ... e-20110902

Author:  niman [ Sat Sep 03, 2011 6:27 am ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

Health officials say a novel strain of swine flu has sickened two children in Pennsylvania and Indiana.

One had contact with pigs. The other is believed to have been infected by a caregiver who had contact with pigs, suggesting the virus can spread person-to-person.

The Centers for Disease Control and Prevention says the new virus contains a gene from the H1N1 swine flu that caused a worldwide scare two years ago, plus parts of other viruses that have infected pigs over the last decade.

The children were infected in July and August and have recovered. Both had received flu shots last year.

Officials are investigating other reports of illness in people who attended an agricultural fair in Pennsylvania. No additional cases have been confirmed so far.

http://www.cbsnews.com/stories/2011/09/ ... 1127.shtml

Author:  niman [ Sat Sep 03, 2011 6:48 am ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

By Jo Ciavaglia Staff writer | 3 comments


Federal and state health officials say a new swine flu strain recently sickened two preschool age children in Pennsylvania and Indiana, but they cautioned the cases appear to be isolated.

The new virus contains a gene from the H1N1 swine flu, which caused a global pandemic two years ago, and parts of other previous, rare swine flu viruses called H3N2, according to the Centers for Disease Control and Prevention, which included the two cases in a Morbidity and Mortality Weekly Report, issued online Friday.



Both the infected children, ages 2 and 5, had direct or indirect contact with pigs prior to becoming sick, according to the CDC. Both children have recovered and each received a seasonal flu shot last year that contained protection against H1N1.

No additional cases have been confirmed as of Friday.

Scientists found no specific link between the two cases and there is no immediate evidence of sustained human-to-human transmission, the CDC said.

"At this time, with only one case of this kind identified in Pennsylvania, we cannot yet say there is a significant risk to public health," said Pennsylvania Department of Health Secretary Dr. Eli Avila. "However, it is something that we are taking very seriously and actively investigating."

The Pennsylvania Department of Health on Friday issued an advisory urging the public take precautions to prevent the spread of respiratory viruses in light of its investigation into the new swine flu strain. The agency is urging public health professionals to watch for patients with flu-like symptoms and forward lab samples to the state if a patient tests positive for Type-A virus.

State health officials are conducting exposure investigations in Schuylkill and Washington counties among people who attended an agricultural fair.

The most recent case reported appeared in a 2-year-old Schuylkill County girl who attended the fair and had contact with pigs. She became sick on Aug. 20 with a high fever, dry cough and lethargy. She tested positive for Type-A flu at a local hospital emergency room, but was not admitted.

The samples were sent to the state health labs and CDC for further testing, which confirmed the unique strain, which resembles a strain found in an Indiana boy in July. The boy, who has chronic health conditions, reportedly did not have direct exposure to pigs, but one of his caretakers did before the boy became ill.

Bucks County Health Department Director Dr. David Damsker says the discovery of a new flu strain is not unusual, particularly given the CDC's new national surveillance effort designed to identify new flu strains and track flu virus trends.

"We're starting to see more strains that may not have been noticed 20 years ago because we're looking so closely today," Damsker said.

Influenza viruses are commonly found in humans, swine, birds and other animals and there are more than 50 strains of human flu virus alone. Seasonal flu season typically runs December through March.

Each winter, scientists try to predict which flu strains will circulate so they can develop an effective vaccine for the following season. Three strains are picked, two from the Type A family of influenza and one from Type B, but there is no way to predict with 100-percent accuracy which flu strains will be more active each year.

Every year public health officials typically see a few flu strains the seasonal vaccine does not protect against, Damsker said, adding that, based on the two confirmed cases, the new swine strain does not appear any more dangerous than regular flu.

"At this point, we don't think it's anything to be concerned about," he added.

http://www.phillyburbs.com/news/local/c ... a9a2d.html

Author:  niman [ Sat Sep 03, 2011 6:53 am ]
Post subject:  Re: trH3N2 In Pennsylvania and Indiana Match

niman wrote:
By Jo Ciavaglia Staff writer | 3 comments



State health officials are conducting exposure investigations in Schuylkill and Washington counties among people who attended an agricultural fair.

The most recent case reported appeared in a 2-year-old Schuylkill County girl who attended the fair and had contact with pigs. She became sick on Aug. 20 with a high fever, dry cough and lethargy. She tested positive for Type-A flu at a local hospital emergency room, but was not admitted.


http://www.phillyburbs.com/news/local/c ... a9a2d.html

Plot thickening.

Page 2 of 9 All times are UTC - 5 hours [ DST ]
Powered by phpBB® Forum Software © phpBB Group
http://www.phpbb.com/