Rhiza Labs FluTracker Forum

The place to discuss the flu
It is currently Tue May 21, 2013 5:19 pm

All times are UTC - 5 hours [ DST ]




Post new topic Reply to topic  [ 74 posts ]  Go to page 1, 2, 3, 4, 5 ... 8  Next
Author Message
PostPosted: Thu Feb 03, 2011 2:14 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
The week 4 MMWR is reporting a novel influenza (trH3N2) case for 2011. This is the first trH3N2 for 2011. There were four cases in 2010 and one in 2009. All reported trH3N2 cases in the US were identified after the start of the 2009 H1N1 pandemic.

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6004md_w

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Thu Feb 03, 2011 2:36 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
The details on the trH3N2 are not revealed in the current week 4 MMWR. The week 3 MMWR made no mention of a 2011 case

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6003md_w

However, the week 4 report does not indicate the trH3N2 is "current" and does not give the state. However, the footnote does acknowledge a 2011 case and does indicate it is a trH3N2. There were 4 trH3N2 cases in 2009 (two in MN, one in WI and one in PA) and two in 2009 (in KS and IA).

PA has reported many unsubtypable cases, but it remains unclear as to why the cases were classified as unsubtypable, which is normally reserved for novel cases (as opposed to not typed, which simply means that sub-typing wasn't done).

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Fri Feb 04, 2011 1:55 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
niman wrote:
The details on the trH3N2 are not revealed in the current week 4 MMWR. The week 3 MMWR made no mention of a 2011 case

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6003md_w

However, the week 4 report does not indicate the trH3N2 is "current" and does not give the state. However, the footnote does acknowledge a 2011 case and does indicate it is a trH3N2. There were 4 trH3N2 cases in 2009 (two in MN, one in WI and one in PA) and two in 2009 (in KS and IA).

PA has reported many unsubtypable cases, but it remains unclear as to why the cases were classified as unsubtypable, which is normally reserved for novel cases (as opposed to not typed, which simply means that sub-typing wasn't done).

One case of human infection with a novel influenza A virus was reported by the Pennsylvania Department of Health. The patient was infected with a swine origin influenza A (H3N2) virus. The patient reported contact with pigs in the week preceding symptom onset on September 6, 2010, did not require hospitalization, and has since fully recovered. Initial testing of the specimen indicated a seasonal influenza A (H3N2) virus and the specimen was submitted to CDC as a routine surveillance sample. The delay from onset to detection occurred because attempts to culture the virus were unsuccessful. RT-PCR testing confirmed swine-origin influenza A (H3N2). Six other human infections with swine origin influenza A (H3N2) viruses have been identified in the United States during 2009 through 2010, including one other case from Pennsylvania in week 44 of 2010. No epidemiologic links between this case and any of the other cases of swine-origin H3N2 infection have been identified and the viruses from all seven cases have genetic differences indicating different sources of infection.

There is no evidence of human-to-human transmission with this virus; however, early identification and investigation of all human infections with novel influenza A viruses is critical to evaluate the extent of the outbreak and possible human-to-human transmission. Surveillance for human infections with novel influenza A viruses continues year round.

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Fri Feb 04, 2011 2:14 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
The plot is definitely thickening in PA. they have reported SEVERAL untypable cases, including more in the latest report. The CDC comments confirm that these trH3N2 type as seasonal H3N2, so the novel aspect is not determined until there are further tests like antigenic determination of sequences. Thus, there may be MANY more cases sitting at the CDC waiting for further analysis. The latest case symptomatic In September, about the same time as the prior PA trH3N2 case, but is only being reported now, and with NO sequence.

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Fri Feb 04, 2011 2:37 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
niman wrote:
niman wrote:
The details on the trH3N2 are not revealed in the current week 4 MMWR. The week 3 MMWR made no mention of a 2011 case

http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm6003md_w

However, the week 4 report does not indicate the trH3N2 is "current" and does not give the state. However, the footnote does acknowledge a 2011 case and does indicate it is a trH3N2. There were 4 trH3N2 cases in 2009 (two in MN, one in WI and one in PA) and two in 2009 (in KS and IA).

PA has reported many unsubtypable cases, but it remains unclear as to why the cases were classified as unsubtypable, which is normally reserved for novel cases (as opposed to not typed, which simply means that sub-typing wasn't done).

One case of human infection with a novel influenza A virus was reported by the Pennsylvania Department of Health. The patient was infected with a swine origin influenza A (H3N2) virus. The patient reported contact with pigs in the week preceding symptom onset on September 6, 2010,

Note that the PA case was 2 days before the Wisconsin case and six weeks before the other Pennsylvania case. As noted previously, the CDC has NOT said how many additional cases are under investigation. PA has reported MANY unsub-typable cases this year and late last year.

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Fri Feb 04, 2011 2:41 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
Prior commentaries on unsubtypable cases in PA

http://www.recombinomics.com/News/12291 ... pable.html

http://www.recombinomics.com/News/02021 ... inant.html

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Fri Feb 04, 2011 3:42 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
Commentary

http://www.recombinomics.com/News/02041 ... _PA_2.html

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Sat Feb 05, 2011 12:13 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
niman wrote:

North Carolina has also reported an unsubtypable case.

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Sat Feb 05, 2011 12:15 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
PB1 E618D pedigree in H3N2 isolates

EPI293963 A/Minnesota/11/2010 (A/H3N2) segment 2 (PB1) 27.0 5.96979
EPI291895 A/Wisconsin/12/2010 (A/H3N2) segment 2 (PB1) 27.0 5.64229
EPI291867 A/Pennsylvania/14/2010 (A/H3N2) segment 2 (PB1) 27.0 5.64229
EPI291840 A/Minnesota/09/2010 (A/H3N2) segment 2 (PB1) 27.0 5.64229
EPI244299 A/Kansas/13/2009 (A/H3N2) segment 2 (PB1) 27.0 5.67207

_________________
www.twitter.com/hniman


Top
 Profile  
 
PostPosted: Sat Feb 05, 2011 12:27 pm 
Online

Joined: Wed Aug 19, 2009 10:42 am
Posts: 27348
Location: Pittsburgh, PA USA
Week 52 PA report has unsubtypable case

viewtopic.php?f=9&t=193&start=179

Image

_________________
www.twitter.com/hniman


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 74 posts ]  Go to page 1, 2, 3, 4, 5 ... 8  Next

All times are UTC - 5 hours [ DST ]


Who is online

Users browsing this forum: gjs0708, Lousheseaveax, meteorjosh, niman and 130 guests


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Search for:
Jump to:  
Powered by phpBB® Forum Software © phpBB Group