niman wrote:
niman wrote:
10 of the sequences, collected between Dec 22, 2010 and Feb 2, 2011 map to the same branch and, as indicated by names below, are widely distributed throughout Japan, signaling clonal expansion:
A/HIROSHIMA/17/2011
A/WAKAYAMA/23/2011
A/SAPPORO/19/2011
A/NIIGATA/51/2011
A/HOKKAIDO/12/2011
A/YOKOHAMA/29/2011
A/NIIGATA/62/2011
A/KOBE/537/2011
A/YAMAGUCHI/35/2010
A/HIROSHIMA/49/2011
The clonal expansion is inconsistant with figures cited by WHO
http://www.who.int/csr/disease/influenz ... index.htmlThe above sequences were generated by NIID (and 8 of the 10 were from Jan, 2011 collections), who reported an H274Y rate of 1.5% in January. That rate jumped to 4.8% in Feb and 5.8% in Mar, but is likely a gross undercount due to the WHO "agreement" to count samples with H274Y levels below 50% was wild type. Moreover, clonal expansion would NOT require Tamiflu selection, so the citation of linkage to treatment also remains HIGHLY suspect (most samples are collected PRIOR to treatment and therefore post collection Tamiflu treatment would be an irrelevent fact that could be used to misclassify samples and create the WHO H274Y reports claiming a high linkage to treatment, which lack credibility).
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