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http://www.recombinomics.com/News/05141 ... _2011.html

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Orioles outfielder Nick Markakis was not in Wednesday's starting lineup against the Mariners and wasn't at Camden Yards at all, as the right fielder is dealing with a flu-like virus that sidelined him for the first time this season.

Markakis went to visit his wife, Christina, who was hospitalized with the illness after Tuesday's game, and he came down with the sickness himself.

"I told him to text me and keep me up to speed on what was going on with her," manager Buck Showalter said prior to Wednesday's game. "The next thing I know Nicky got it during the night, and he was pretty sick. I talked to him about an hour ago and he starting to feel better. But it is a highly contagious thing. So the doctors feel he should stay home."

http://mlb.mlb.com/news/article.jsp?ymd ... Id=rss_bal

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Extensive recombination in Delaware and Maryland isolates with H274Y

PB1 G154D

EPI315884 A/Thailand/CU-H2911/2011 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI315409 A/Chile/19/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI309982 A/Maryland/06/2011 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI309968 A/Maryland/04/2011 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI309875 A/Delaware/08/2011 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI288159 A/Chile/4406/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI288143 A/Chile/4182/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI288135 A/Chile/4181/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI288111 A/Chile/3905/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI288087 A/Chile/3760/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI288071 A/Chile/3553/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI288063 A/Chile/3467/2009 (A/H1N1) segment 2 (PB1) 27.0 6.41033
EPI274505 A/Rome/709/2009 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI219088 A/Wisconsin/629-S0201/2009 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI217040 A/New Mexico/07/2009 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI213243 A/Shizuoka-C/97/2009 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI211406 A/Chile/6536/2009 (A/H1N1 swl) segment 2 (PB1) 27.0 6.41033
EPI177245 A/mallard/New Zealand/479-8/2005 (A/H6N2) segment 2 (PB1) 27.0 6.41033

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PB1 sequence of Maryland/06 and Delaware/08 are identical, and are in the S188T sub-clade, but both have the above polymorphisms which is in Maryland/04 from the Chihuahua subclade. All three have H274Y.

Similarly, the first three isolates from Delaware with H274 are also the S188T sub-clade, but they have A189T, which is in the Chihuahua sub-clade, including Maryland/04.

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CDC release 50 sets of 2011 H1N1 sequences today. NONE were from Delaware (and the only MD sequence was a clone of MD/04).

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