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PostPosted: Tue Apr 26, 2011 3:17 am 
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does WHO/PAHO even mention D225N ?

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PostPosted: Tue Apr 26, 2011 3:22 am 
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gsgs wrote:
what do you guess is the first occurrance of the Chi-strain ?

I have A/Germany/AF2207/2010/01/19 with
A142G,G536A,G607A,C681T,A957G

AF seems to be from an US-airforce base in Germany,
could have come from anywhere in the world

Larger series were in the spring and summer of 2010 with the largest number from Spain. It pretty much disappeared in the fall of 2010 and then started to take off in Ecuador, as indicated in WHO report, in early 2011.

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PostPosted: Tue Apr 26, 2011 3:29 am 
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gsgs wrote:
does WHO/PAHO even mention D225N ?

Please. They cite the first 3 sequences of of Chihuahua, which have D225N.
Anyone REMOTELY paying attention knows that Chihuahua and the pandemic alert is all about D225N in the UPPER respiratory tract, no WHO head fakes required.

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PostPosted: Tue Apr 26, 2011 3:33 am 
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niman wrote:
gsgs wrote:
does WHO/PAHO even mention D225N ?

Please. They cite the first 3 sequences out of Chihuahua, which have D225N.
Anyone REMOTELY paying attention knows that Chihuahua and the pandemic alert are all about D225N in the UPPER respiratory tract, no WHO head fakes required.

Reality check

http://www.recombinomics.com/News/04031 ... Novel.html

LOCUS CY089387 1777 bp cRNA linear VRL 02-APR-2011
DEFINITION Influenza A virus (A/Mexico/InDRE1945/2011(H1N1)) hemagglutinin
(HA) gene, complete cds.
ACCESSION CY089387
VERSION CY089387.1 GI:327412375
DBLINK Project: 37813
KEYWORDS .
SOURCE Influenza A virus (A/Mexico/InDRE1945/2011(H1N1))
ORGANISM Influenza A virus (A/Mexico/InDRE1945/2011(H1N1))
Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
Influenzavirus A.
REFERENCE 1 (bases 1 to 1777)
AUTHORS Ramirez-Gonzalez,J.E., Alcantara-Perez,P., Rodriguez-Maldonado,A.,
Wong-Arambula,C., Del-Mazo,J.C., Esau,D., Olivera-Diaz,H.,
Barrera-Badillo,G., Lopez-Martinez,I., Guzman-Bracho,C. and
Alpuche-Aranda,C.
TITLE Detection of D222N substitution in Pandemic Influenza A (H1N1)
Virus in Chihuahua, Mexico
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1777)
AUTHORS Ramirez-Gonzalez,J.E., Alcantara-Perez,P., Rodriguez-Maldonado,A.,
Wong-Arambula,C., Del-Mazo,J.C., Esau,D., Olivera-Diaz,H.,
Barrera-Badillo,G., Lopez-Martinez,I., Guzman-Bracho,C. and
Alpuche-Aranda,C.
TITLE Direct Submission
JOURNAL Submitted (02-APR-2011) Laboratorio de Genoma de Patogenos,
Instituto de Diagnostico y Referencia Epidemiologicos, Crpio 470
Col. Sto Tomas, Mexico, DF 11340, Mexico
FEATURES Location/Qualifiers
source 1..1777
/organism="Influenza A virus
(A/Mexico/InDRE1945/2011(H1N1))"
/mol_type="viral cRNA"
/strain="A/Mexico/InDRE1945/2011"
/serotype="H1N1"
/isolation_source="Pharyngeal swab"
/host="human; gender M; age 36"
/db_xref="taxon:1003291"
/segment="4"
/country="Mexico: Chihuahua"
/collection_date="Mar-2011"
gene 33..1733
/gene="HA"
CDS 33..1733
/gene="HA"
/function="receptor binding and fusion protein"
/codon_start=1
/product="hemagglutinin"
/protein_id="AEA74031.1"
/db_xref="GI:327412376"
/translation="MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVT
HSVDLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETSSS
DNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKS
FYNNLIWLVKKGNSYPKLNKSYINDKGKEVLVLWGIHHPSTSTDQQSLYQNADAYVFV
GTSRYSKKFKPEIAIRPKVRNQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMER
NAGSGIIISDTPIHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATG
LRNVPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEI
TNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENER
TLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSE
EAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAISFWMCSNGSLQCRICI
"
sig_peptide 33..83
/gene="HA"
mat_peptide 84..1064
/gene="HA"
/product="HA1"
mat_peptide 1065..1730
/gene="HA"
/product="HA2"
ORIGIN
1 agcaaaagca ggggaaaaca aaagcaacaa aaatgaaggc aatactagta gttctgctat
61 atacatttgc aaccgcaaat gcagacacat tatgtatagg ttatcatgcg aacaattcaa
121 cagacactgt agacacagta ctagaaaaga atgtaacagt aacacattct gttgaccttc
181 tagaagacaa gcataacggg aaactatgca aactaagagg ggtagcccca ttgcatttag
241 gtaaatgtaa cattgctggc tggatcctgg gaaatccaga gtgtgaatca ctctccacag
301 caagctcatg gtcttacatt gtggaaacat ctagttcaga caatggaacg tgttacccag
361 gagatttcat cgattatgag gagctaagag agcaattgag ctcagtgtca tcatttgaaa
421 ggtttgaaat attccccaag acaagttcat ggcccaatca tgactcgaac aaaggtgtaa
481 cggcagcatg tccacatgct ggagcaaaaa gcttctacaa caatttaata tggctagtta
541 aaaaaggaaa ttcataccca aagctcaaca aatcctacat taatgataaa gggaaagaag
601 tcctcgtgct atggggcatt caccatccat ctactagtac tgaccaacaa agtctctatc
661 agaatgcaga tgcatatgtt tttgtgggga catcaagata cagcaagaag tttaagccgg
721 aaatagcaat aagacccaaa gtgaggaatc aagaagggag aatgaactat tactggacac
781 tagtagagcc gggagacaaa ataacattcg aagcaactgg aaatctagtg gtaccgagat
841 atgcattcgc aatggaaaga aatgctggat ctggtattat catttcagat acaccaatcc
901 acgattgcaa tacaacttgt cagacaccca agggggctat aaacaccagc ctcccatttc
961 agaatataca tccgatcaca attggaaagt gtccaaaata tgtaaaaagc acaaaattga
1021 gactggccac aggattgagg aatgtcccgt ctattcaatc tagaggccta tttggggcca
1081 ttgccggttt cattgaaggg gggtggacag gaatggtaga tggatggtac ggttatcacc
1141 atcaaaatga gcaggggtca ggatatgcag ccgacctgaa gagcacacag aatgccattg
1201 acgagattac taacaaagta aattctgtta ttgaaaagat gaatacgcag ttcacagcag
1261 taggcaaaga gttcaaccac ctggaaaaaa gaatagagaa tttaaataaa aaagttgatg
1321 atggtttcct ggacatttgg acttacaatg ccgaactgtt ggttctattg gaaaatgaaa
1381 gaactttgga ctaccacgat tcaaatgtga agaacttata tgaaaaggta agaagccagt
1441 taaaaaacaa tgccaaggaa attggaaacg gctgctttga attttaccac aaatgcgata
1501 acacgtgcat ggaaagtgtc aaaaatggga cttatgacta cccaaaatac tcagaggaag
1561 caaaattaaa cagagaagaa atagatgggg taaagctgga atcaacaagg atttaccaga
1621 ttttggcgat ctattcaact gtcgccagtt cattggtact ggtagtctcc ctgggggcaa
1681 tcagtttctg gatgtgctct aatgggtctc tacagtgtag aatatgtatt taacattagg
1741 atttcagaag catgagaaaa acacccttgt ttctact

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PostPosted: Tue Apr 26, 2011 3:36 am 
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was there increased virulence or anything unusual (D225N etc.)
in that strain before ?

Spain,Ecuador

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PostPosted: Tue Apr 26, 2011 3:37 am 
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gsgs wrote:
does WHO/PAHO even mention D225N ?

You remain data analysis challenged.
From WHO April 6 report:

Institute of Diagnosis and Epidemiological Reference (InDRE) of Mexico carried out genetic sequencing of the first three pandemic (H1N1) 2009 influenza cases (two fatal cases and one mild),

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PostPosted: Tue Apr 26, 2011 3:38 am 
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seems to go away in Northern summer now
like last year

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PostPosted: Tue Apr 26, 2011 3:41 am 
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> Detection of D222N substitution in Pandemic Influenza A (H1N1)
> Virus in Chihuahua, Mexico

"detection" doesn't say how prevalent it was/is

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PostPosted: Tue Apr 26, 2011 3:41 am 
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gsgs wrote:
seems to go away in Northern summer now
like last year

In 2009 it went to summer camp (but without D225N in the upper respiratory tract).

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PostPosted: Tue Apr 26, 2011 3:44 am 
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could it be, that the Chi-strain is better adapted to summer weather,
but can't stand the competition (via human immunity) during
waves of other flus ?

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