Rhiza Labs FluTracker Forum

Deleware has four cases of H274Y compared to 3 reported for the entire country.

http://www.cdc.gov/flu/weekly/

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Commentary

http://www.recombinomics.com/News/03241 ... 4Y_DE.html

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Could finally be the start of what we expected last year.

Would love to know how many were tested in the last few weeks. They have tested 82 since November 2010. You would think 4 would be a very large ratio compared to recently tested. Very large indeed.

It is worth noting that release of H1N1 by the CDC at GISAID appears to be lagging. The CDC typically releases three batches of sequences (H1N1, H3N2, influenza B) collected in the same time frame. This week they released H3N2 and influenza B sequences which were largely sequences collected in late December, 2010 or 2011. However, the corresponding batch of H1N1 sequences has not been released. The last H1N1 release was Febraury 2, and was larely composed of sequences from late 2010.

It is likley that at least one of the H274Y positive sequences from Delaware would be in the next released. The clustering of the 4 cases in time and space suggest that most or all will be closely related to each other. The next batch of h1N1 sequences should be interesting, espacially if they include collections from Febraury/March.

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Delaare has 4 of the 5 cases reported for the entire country

Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2010 Virus
Samples
tested (n) Resistant
Viruses,
Number (%)
Oseltamivir Virus
Samples
tested (n) Resistant
Viruses,
Number (%)
Zanamivir
Seasonal Influenza A (H1N1) 0 0 (0.0) 0 0 (0.0)
Influenza A (H3N2) 473 0 (0.0) 471 0 (0.0)
Influenza B 461 0 (0.0) 461 0 (0.0)
2009 Influenza A (H1N1) 670 5 (0.7) 191 0 (0.0)

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Four NA sequences with H274Y from DE were released today by the CDC. 3 associated HA sequences were released. All three had S188T and two also had A189T.

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HA sequences of MD/06/2011 and DE/08/2011 are identical and NA sequences from both have H274Y, indicating Tamiflu resistance is transmitting in DE and MD. Similarly, DE/04/2011 and DE/07/2011 HA sequences are identical (and have S188T and A189T) and both have H274Y, indicating Tamiflu resistance in this sub-clade is also transmitting.

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NA sequences reelased today with H274Y

EPI309995 A/Maryland/08/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309989 A/Maryland/07/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309983 A/Maryland/06/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309969 A/Maryland/04/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309953 A/Maine/04/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309907 A/Indiana/04/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309876 A/Delaware/08/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309869 A/Delaware/07/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309864 A/Delaware/06/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309856 A/Delaware/04/2011 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077
EPI309836 A/Colorado/11/2010 (A/H1N1 swl) segment 6 (NA) 27.0 6.19077

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http://www.wgmd.com/?p=22447


NEWS RELEASE: SIXTH ANTI-VIRAL RESISTANT FLU CASE IDENTIFIED

Delaware’s Division of Public Health (DPH) laboratory results confirm a sixth Delaware case of antiviral-resistant influenza for the 2010 – 2011 flu season. A 55 year-old woman from Kent County was infected with an influenza strain found to be resistant to oseltamivir, the preferred treatment antiviral medication used to treat confirmed cases of influenza.

The Division of Public Health has found another case of anti-viral resistant flu in Delaware. A 55 year old Kent County woman has been found with a strain of influenza that is resistant to tamiflu, which is the preferred treatment for people confirmed with influenza. However there are three other anti-viral medications approved for use. While it’s late in the flu season – state Health officials say you should still take precautions to guard against the flu.