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PostPosted: Fri Mar 25, 2011 3:58 pm 
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http://www.cidrap.umn.edu//cidrap/conte ... sscan.html

Cancer patients show high rate of drug-resistant H1N1 mutation
8:33

One fourth of a small sample of patients with leukemia or other cancers who contracted pandemic 2009 H1N1 influenza had the mutated form known to cause oseltamivir resistance, according to a new study. Seattle-area researchers examined 33 samples from hematology-oncology patients who had confirmed 2009 H1N1 flu. Of the 8 with H275Y mutations, 1 had severe pneumonia, 3 had mild pneumonia, and 4 had upper respiratory tract infections. All patients with mild pneumonia and 3 of the 4 with upper respiratory tract infections exhibited prolonged H1N1 virus shedding, several for more than 60 days. All patients with the mutation had received oseltamivir.
Mar 23 Emerg Infect Dis study


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PostPosted: Sat Mar 26, 2011 9:33 am 
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Joined: Wed Aug 19, 2009 10:42 am
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Location: Pittsburgh, PA USA
Tex wrote:
http://www.cidrap.umn.edu//cidrap/content/influenza/avianflu/news/mar2411newsscan.html

Cancer patients show high rate of drug-resistant H1N1 mutation
8:33

One fourth of a small sample of patients with leukemia or other cancers who contracted pandemic 2009 H1N1 influenza had the mutated form known to cause oseltamivir resistance, according to a new study. Seattle-area researchers examined 33 samples from hematology-oncology patients who had confirmed 2009 H1N1 flu. Of the 8 with H275Y mutations, 1 had severe pneumonia, 3 had mild pneumonia, and 4 had upper respiratory tract infections. All patients with mild pneumonia and 3 of the 4 with upper respiratory tract infections exhibited prolonged H1N1 virus shedding, several for more than 60 days. All patients with the mutation had received oseltamivir.
Mar 23 Emerg Infect Dis study

More confimation os silent spread of H274Y, which is detected after Tamiflu treatment. Most samples that are "negative" for H274Y are from collections prior to treatment, when levels of 1-5% are below detection limits.
Nonsense about "spontaneous" and "random" mutations becomes more obvious, as more data are released.

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