Rhiza Labs FluTracker Forum

The CDC has designated A/India/5103/2010 as a LOW REACTOR. Although it has a few addition HA changes, it has S186P and S188T.

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www.twitter.com/hniman

Sorry for not being very with it - where is this A/India/5103/2010 being found, apart from India? Is this one of the samples from PA?

S186P and S188T are used by H1N1 to escape immunological responses to last year's H1N1 (generated by prior infection or vaccination). In the UK 22/41 sequences have S188T and 14/41 have S188T, so 36/41 have one or another. The same is true for the US (many of the recent sequences have one or the other). The sequence in India has both and designated as a LOW REACTOR by the CDC.

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www.twitter.com/hniman

Many of the sequences that were recently released at GISAID were submitted in late December, but just released, which is why they are located below the UK sequences (order is linked to accession number and these earlier sequences were assigned a number low than those from the UK).

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www.twitter.com/hniman

S186P updated pedigree

EPI300987 A/Bangladesh/8003/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI299427 A/northern shoveler/Mississippi/09OS025/2009 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI299218 A/northern pintail/Interior Alaska/8BM3736/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI298423 A/Shahriar/5336/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI298420 A/Bandar Abbas/5096/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI297671 A/duck/Victoria/30a/1981 (A/H12N7) segment 4 (HA) 27.0 5.92613
EPI296646 A/Thailand/ST_0153/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI296645 A/Thailand/ST_0111/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI296644 A/Thailand/ST_0113/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI296643 A/Thailand/ST_0112_1/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI296642 A/Thailand/SN_0112_2/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295750 A/England/5500192/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295741 A/England/139/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295740 A/England/119/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295738 A/England/125/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295733 A/England/99/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295732 A/England/4500186/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295731 A/England/93/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295730 A/England/83/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295729 A/England/91/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295728 A/England/90/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295727 A/England/87/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295725 A/England/85/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295724 A/England/79/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295519 A/New Hampshire/03/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295516 A/Bhutan/72/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295501 A/Bangladesh/1685/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295481 A/Pennsylvania/17/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295474 A/Pennsylvania/16/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295459 A/India/5103/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295396 A/SAGA/90/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295385 A/SAGA/85/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294682 A/England/118/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294040 A/NAGANO/2181/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294029 A/YOKOHAMA/84/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI292019 A/swine/Iowa/H02NJ56371/2002 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI292018 A/swine/Iowa/H02NJ56391/2002 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI292017 A/swine/Iowa/H02PW7/2002 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI292012 A/swine/Iowa/H03HS5/2003 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI292010 A/swine/Iowa/H03LJ10/2003 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI291846 A/Minnesota/10/2009 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI291704 A/Oklahoma/11/1990 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI291696 A/Nebraska/01/1992 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI291688 A/Minnesota/18/1995 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI291680 A/Indiana/05/1995 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI291672 A/Indiana/01/1994 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI288179 A/Belgorod/RII4/2009 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI286652 A/Stockholm/5/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI284314 A/Myanmar/M536/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI283319 A/swine/Saitama/1/2004 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI283318 A/swine/Saitama/27/2003 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI283317 A/swine/Saitama/1/2005 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI281270 A/swine/Kentucky/02086/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI280326 A/Wisconsin/08/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI280286 A/Florida/13/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI279208 A/CANBERRA/8/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI279016 A/GOROKA/16/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI278875 A/India/007/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI278516 A/Ukraine/122/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI278514 A/Ukraine/123/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI277042 A/Singapore/478/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI273897 A/India/3725/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI273865 A/Washington/01/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI273829 A/Kentucky/06/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI272842 A/Qingdao/492/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI272392 A/CHIBA-C/22/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI272008 A/WELLINGTON/1/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI271861 A/swine/Chiba/1/1991 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI269839 A/turkey/Ontario/FAV114-17/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI269838 A/turkey/Ontario/FAV117-1C/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI269540 A/swine/Minnesota/03022/2010 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI259196 A/swine/NC/19646/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI257748 A/Jiangxi-Donghu/SWL1172/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI256035 A/Thessaloniki/791/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI255754 A/swine/MN/23506/2009 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI252354 A/Ontario/25913/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI246200 A/swine/IL/5265-2/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI246197 A/swine/IL/5265-1/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI244474 A/swine/Taichung/E3/1992 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI244053 A/swine/Illinois/02957/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI244041 A/KYOTO/2/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI242894 A/Swine/Italy v147/81 (A/H1) segment 4 (HA) 27.0 5.92613
EPI240273 A/turkey/NC/19762/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI240232 A/swine/Skane/1321/1983 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI240228 A/swine/QC/81 (A/H1) segment 4 (HA) 27.0 5.92613
EPI239970 A/Swine/Indiana/1726/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI239859 A/swine/QC/91 (A/H1) segment 4 (HA) 27.0 5.92613
EPI239831 A/chicken/PA/35154/1991 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI239292 A/swine/Saitama/1996 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI238359 A/Chernihiv/857/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI237302 A/California/VRDL7/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI234428 A/swine/Malaysia/3966/1984 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI230786 A/Ankara/17/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI230497 A/swine/4/Mexico/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI217181 A/Tennessee/17/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI215819 A/DARWIN/2126/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI210034 A/FUKUOKA-C/2/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI188346 A/ruddy turnstone/Delaware/Sg-00540/2008 (A/H12N4) segment 4 (HA) 27.0 5.92613
EPI188320 A/ruddy turnstone/New Jersey/Sg-00530/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI180214 A/swine/North Carolina/9675/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180208 A/swine/North Carolina/36681/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180207 A/swine/North Carolina/29698/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180206 A/swine/North Carolina/26762/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180200 A/swine/North Carolina/41621/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180199 A/swine/North Carolina/37895/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180198 A/swine/North Carolina/35279/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180197 A/swine/North Carolina/29482/2003 (A/H1) segment 4 (HA) 27.0 5.92613
EPI180163 A/swine/North Carolina/46203/2003 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI180119 A/swine/North Carolina/63607-9/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI180115 A/swine/North Carolina/63607-37/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI180105 A/swine/North Carolina/225-13/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI180093 A/swine/Minnesota/63607-26/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI180090 A/swine/Minnesota/63607-15/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI180086 A/swine/Minnesota/225-4/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI180076 A/swine/Iowa/225-8/2008 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI178968 A/Swine/Indiana/1726/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI178960 A/swine/Wisconsin/1915/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI178952 A/Maryland/12/1991 (A/H1N1 seasonal) segment 4 (HA) 27.0 5.92613
EPI177581 A/swine/Hong Kong/NS1659/2001 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI177542 A/swine/Hong Kong/103/1993 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI175607 A/ruddy turnstone/New Jersey/Sg-00560/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175527 A/ruddy turnstone/New Jersey/Sg-00509/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175512 A/ruddy turnstone/New Jersey/Sg-0505/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175507 A/ruddy turnstone/New Jersey/Sg-00501/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175502 A/ruddy turnstone/New Jersey/Sg-00500/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175497 A/ruddy turnstone/New Jersey/Sg-00497/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175487 A/ruddy turnstone/New Jersey/Sg-00495/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175477 A/ruddy turnstone/New Jersey/Sg-00493/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175462 A/ruddy turnstone/New Jersey/Sg-00488/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175457 A/ruddy turnstone/New Jersey/Sg-00484/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175452 A/red knot/New Jersey/Sg-00483/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175447 A/ruddy turnstone/New Jersey/Sg-00481/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175432 A/red knot/New Jersey/Sg-00478/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI175422 A/ruddy turnstone/New Jersey/Sg-00476/2008 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI173035 A/swine/Ehime/1/1980 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI173027 A/swine/Niigata/1/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI173019 A/swine/Hokkaido/2/81 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI172963 A/swine/Ratchaburi/NIAH550/2003 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI171236 A/swine/Tennessee/107/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI171133 A/swine/Wisconsin/30954/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI165951 A/turkey/NC/17026/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI165697 A/swine/Memphis/1/1990 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI158914 A/turkey/IA/21089-3/1992 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI158487 A/ruddy turnstone/DE/1444/00 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI156233 A/swine/Tennessee/109/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI156208 A/turkey/KS/4880/1980 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI155004 A/swine/Kyoto/3/1979 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI137509 A/swine/Tennessee/9/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI131398 A/swine/Ehime/1/80 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI131392 A/swine/Hong Kong/1/1974 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI131142 A/Sw/Quebec/1747/90 (A/H1) segment 4 (HA) 27.0 5.92613
EPI131094 A/swine/England/117316/86 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI130937 A/WI/4755/1994 (A/H1N1 seasonal) segment 4 (HA) 27.0 5.92613
EPI130935 A/WI/4754/1994 (A/H1N1 seasonal) segment 4 (HA) 27.0 5.92613
EPI130753 A/swine/Hokkaido/2/81 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI130749 A/swine/Iowa/17672/88 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI130735 A/swine/Hong Kong/172/1993 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI130503 A/swine/IN/1726/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI129192 A/MD/12/1991 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI125670 A/swine/Korea/GC0503/2005 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI124036 A/swine/North Carolina/36883/2002 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI119784 A/turkey/Kansas/4880/1980 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI116749 A/swine/Guangxi/13/2006 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI100032 A/swine/Alberta/56626/03 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI100014 A/swine/Ontario/57561/03 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI90159 A/mallard/Alberta/52/1997 (A/H12N5) segment 4 (HA) 27.0 5.92613
EPI78199 A/swine/Nagasaki/1/1990 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI78197 A/swine/Nagasaki/1/1989 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI77691 A/swine/Iowa/1/1986 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI77673 A/swine/California/T9001707/1991 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI76853 A/swine/Tennessee/7/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI76834 A/swine/Tennessee/4/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI76283 A/swine/Wisconsin/30747/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI76264 A/swine/Tennessee/3/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI76245 A/swine/Iowa/2/1987 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI74706 A/swine/Tennessee/8/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI74687 A/swine/Tennessee/5/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI74669 A/swine/Iowa/2/1985 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI74194 A/swine/Tennessee/2/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI74175 A/swine/Tennessee/118/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI73834 A/swine/Iowa/24297/1991 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72257 A/swine/Tennessee/112/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72238 A/swine/Tennessee/106/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72219 A/swine/Tennessee/105/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72200 A/swine/Iowa/100/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72181 A/swine/Tennessee/10/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72162 A/swine/Ontario/6/1981 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72143 A/swine/Ontario/3/1981 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72124 A/swine/Ontario/2/1981 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI72086 A/swine/Tennessee/23/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI69253 A/swine/Tennessee/37/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68791 A/swine/Kansas/3024/1987 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68772 A/swine/Arizona/148/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68753 A/swine/Wisconsin/663/1980 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68734 A/swine/Tennessee/10/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68715 A/swine/Tennessee/88/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68696 A/swine/Tennessee/87/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68658 A/swine/Tennessee/84/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68649 A/swine/Tennessee/96/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68630 A/swine/Tennessee/61/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68628 A/swine/Tennessee/48/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68609 A/swine/Minnesota/24/1975 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI68591 A/Ohio/3559/1988 (A/H1N1 seasonal) segment 4 (HA) 27.0 5.92613
EPI64011 A/swine/Wisconsin/629/1980 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI63973 A/swine/Ontario/1/1981 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI63955 A/swine/Iowa/31483/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI63937 A/swine/Iowa/1/1987 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62860 A/swine/Maryland/23239/1991 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62842 A/swine/Kansas/3228/1987 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62804 A/swine/Wisconsin/661/1980 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62785 A/swine/Wisconsin/641/1980 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62748 A/swine/Wisconsin/1915/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62729 A/swine/Wisconsin/11/1980 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62691 A/swine/Tennessee/11/1978 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62653 A/swine/Ontario/7/1981 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62634 A/swine/Ontario/4/1981 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62615 A/swine/Nebraska/123/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62596 A/swine/Minnesota/5892-7/1979 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62577 A/swine/Minnesota/27/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62558 A/swine/Kentucky/1/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62521 A/swine/Iowa/17672/1988 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62503 A/swine/Iowa/3/1985 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62447 A/swine/Tennessee/82/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62428 A/swine/Tennessee/79/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62409 A/swine/Tennessee/65/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62390 A/swine/Tennessee/62/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62371 A/swine/Tennessee/10/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62067 A/swine/Tennessee/64/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62029 A/swine/Tennessee/31/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI62010 A/swine/Tennessee/21/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61991 A/swine/Tennessee/19/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61972 A/swine/Iowa/4/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61896 A/swine/Iowa/1/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61878 A/swine/Tennessee/19/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61859 A/swine/Tennessee/17/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61840 A/swine/Tennessee/15/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61821 A/swine/Tennessee/7/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI61802 A/swine/Tennessee/3/1976 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI42074 A/laughing gull/Delaware/94/2000 (A/H12N4) segment 4 (HA) 27.0 5.92613
EPI31057 A/swine/Tennessee/25/1977 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI17873 A/duck/NC/91347/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI15268 A/Swine/Korea/CY02/02 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14862 A/SW/MN/17138/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14856 A/SW/MO/1877/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14850 A/SW/CO/17871/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14848 A/SW/OH/7802/00 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14846 A/SW/NE/18339/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14844 A/SW/MN/22860-S/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14842 A/SW/MN/22860-T/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14840 A/SW/NE/21147/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14832 A/SW/MN/3227/00 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14828 A/SW/MN/16356/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14820 A/SW/MN/12883/00 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14818 A/SW/AR/12491/00 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14694 A/Swine/Minnesota/1713/00/ (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI14566 A/Turkey/MO/24093/99 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI9345 A/Swine/Iowa/930/01 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI9343 A/Swine/Minnesota/55551/00 (A/H1N2) segment 4 (HA) 27.0 5.92613
EPI6767 A/Swine/Wisconsin/464/98 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI6765 A/Swine/Wisconsin/458/98 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI6761 A/Swine/Wisconsin/238/97 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI6759 A/Swine/Wisconsin/235/97 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI6749 A/Swine/Wisconsin/136/97 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI6747 A/Swine/Wisconsin/125/97 (A/H1N1) segment 4 (HA) 27.0 5.92613
EPI4895 A/swine/Hokkaido/2/81 (A/H1N1) segment 4 (HA) 27.0 5.92613

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S188T pedigree update

EPI300983 A/Kentucky/09/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI300975 A/Utah/05/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI300972 A/Kentucky/08/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI298421 A/Karaj/5327/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI297191 A/Sendai/TU617/2009 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI296641 A/Thailand/SN_0116/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295760 A/England/5040499/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295759 A/England/280/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295758 A/England/4940476/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295757 A/England/4920303/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295756 A/England/4880378/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295755 A/England/142/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295749 A/England/5000135/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295748 A/England/5000125/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295747 A/England/4980078/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295746 A/England/4980074/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295745 A/England/4960201/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295744 A/England/4940126/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295743 A/England/4860049/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295742 A/England/4840022/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295739 A/England/126/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295736 A/England/107/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295734 A/England/106/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295726 A/England/86/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295513 A/Thailand/742/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295498 A/Wisconsin/10/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295495 A/Thailand/594/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295459 A/India/5103/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295417 A/Wisconsin/09/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295411 A/Arizona/08/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI295382 A/KANAGAWA/74/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294674 A/England/4880374/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294417 A/VICTORIA/670/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294405 A/BRUNEI/218/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294391 A/SYDNEY/217/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294388 A/SYDNEY/220/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294297 A/PERTH/198/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294282 A/BRISBANE/209/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294195 A/BRISBANE/69/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI294115 A/VICTORIA/833/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI287020 A/Ghana/FS-10-4259/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI287018 A/Ghana/FS-10-4241/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI286992 A/Johannesburg/119/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI286990 A/Johannesburg/115/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI284010 A/Thailand/34-9937/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI284007 A/Thailand/34-9912/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI280311 A/India/8910/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI280289 A/Florida/14/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI279083 A/CHRISTCHURCH/15/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI279064 A/VICTORIA/512/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI278873 A/India/8910/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI278871 A/India/5107/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613
EPI255118 A/swine/Thailand/CU-RA75/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.92613

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So any sample that has S188T OR S186P has been designated a low reactor, or does it have to have BOTH to be a low reactor? (Just trying to make sure feeble brain gets it.)

The CDC designated the sample with both as a low reactor, but the CDC assay is NOT very sensitive. In real life, it is VERY likely that the vast majority of samples with S188T OR S186P will escape from last season's antibodies, which is why these two markers are spreading so quickly and are in 36/41 HA sequences from the UK.

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Thank you.

S186P (as a mixture) and S188T is also in A/KANAGAWA/74/2010 (submitted by NIID to GISAID).

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