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PostPosted: Fri Feb 04, 2011 12:37 am 
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Jim wrote:
niman wrote:
All of the above refers to HA sequences. It is clear that the issues in the UK will soon become US issues.

And yet the CDC is silent and public health officials are acting as though the flu peak has passed. I just don't understand it. They have access to the same information most of us do.

The CDC did the sequencing.

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PostPosted: Fri Feb 04, 2011 12:46 am 
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niman wrote:
Jim wrote:
niman wrote:
All of the above refers to HA sequences. It is clear that the issues in the UK will soon become US issues.

And yet the CDC is silent and public health officials are acting as though the flu peak has passed. I just don't understand it. They have access to the same information most of us do.

The CDC did the sequencing.

Don't they perceive this as a potentially serious problem? If so, I would expect some kind of news conference or warning to alert hospitals to prepare and even (God forbid the inconvenience) plans for school closings.

I'm sure the scientists at the CDC understand the implications of the mutations, but the policy makers and public relations people aren't acting.

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I used to think I had to understand in order to believe, but then I realized that I had to believe in order to understand. - Augustine


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PostPosted: Fri Feb 04, 2011 12:53 am 
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Jim wrote:
niman wrote:
Jim wrote:
And yet the CDC is silent and public health officials are acting as though the flu peak has passed. I just don't understand it. They have access to the same information most of us do.

The CDC did the sequencing.

Don't they perceive this as a potentially serious problem? If so, I would expect some kind of news conference or warning to alert hospitals to prepare and even (God forbid the inconvenience) plans for school closings.

I'm sure the scientists at the CDC understand the implications of the mutations, but the policy makers and public relations people aren't acting.

Influenza is ALL about politics, no science required.

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PostPosted: Fri Feb 04, 2011 1:45 am 
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> Don't they perceive this as a potentially serious problem? If so

if so, I'd expect them to publish the sequences at genbank.
After all they are a US-government institution and
subject to the freedom-of-information act

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no patents on genes, publish the GISAID sequences !


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PostPosted: Fri Feb 04, 2011 3:08 am 
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gsgs wrote:
> Don't they perceive this as a potentially serious problem? If so

if so, I'd expect them to publish the sequences at genbank.
After all they are a US-government institution and
subject to the freedom-of-information act

GISAID sequences are public and serious scientists registered years ago.

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PostPosted: Fri Feb 04, 2011 3:27 am 
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99.9 % of the population think the current H1N1 vaccine still works as well.


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PostPosted: Fri Feb 04, 2011 7:37 am 
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niman wrote:
Recent S186P

EPI302113 A/Ontario/RV0019/2011 (A/H1N1 swl) segment 4 (HA) 27.0 5.96109
EPI302110 A/Wyoming/01/2011 (A/H1N1 swl) segment 4 (HA) 27.0 5.96109
EPI302098 A/Wisconsin/08/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.96109

Wyoming/01/2011 is identical to Ontario/778873/2010 and England/125/2010. Ontario/RV0019/2011 is very closely related.

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PostPosted: Fri Feb 04, 2011 10:58 am 
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niman wrote:
Recent S186P

EPI302113 A/Ontario/RV0019/2011 (A/H1N1 swl) segment 4 (HA) 27.0 5.96109
EPI302110 A/Wyoming/01/2011 (A/H1N1 swl) segment 4 (HA) 27.0 5.96109
EPI302098 A/Wisconsin/08/2010 (A/H1N1 swl) segment 4 (HA) 27.0 5.96109

The above WI/08/10 isolate had D225N after cloning 3X in eggs. The earlier sequence was wild type.

The CDC appears to be realizing that cloning in eggs mimics growth in patient's lungs, and reveals minor components (like G158E. D225G, D225N) which create major clinical issues.

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PostPosted: Fri Feb 04, 2011 1:17 pm 
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Commentary

http://www.recombinomics.com/News/02041 ... Match.html

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PostPosted: Fri Feb 04, 2011 3:03 pm 
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Dr Niman (I'm the regular Be Well, had to register again due to p/w not working).

I'm reading as much as I can, as usual, and trying to understand the basics from a very layman's POV for myself, friends and some clients.

I'm a bit confused about the low reactor status - I understand there are a number of genetic elements which cause this designation; and now the same flu that was in the UK is now in the US and it looks like Canada too. I have read that among the fatalities in the UK with known vaccine status (or at least made public) about 28% were vaccinated. Since approximately (from what I've read) only 15% of the general population in the UK had received a vax, isn't this evidence of vax failutre?

I see articles (one today on PFI) claiming that the current vax is 90% effective. How can such a contradictory claim be made? Is it pure foolishness, ignorance, disagreement about what the genetic low reactors are, or what?

Any explanations welcome, thank you.


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