Rhiza Labs FluTracker Forum

Pedigree for tandem polymorphisms T635C and C656T

EPI312980 A/Pennsylvania/40/2010 (A/H3N2) segment 4 (HA) 39.9 0.00080
EPI293965 A/Minnesota/11/2010 (A/H3N2) segment 4 (HA) 39.9 0.00080
EPI291898 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 39.9 0.00080
EPI291893 A/Wisconsin/12/2010 (A/H3N2) segment 4 (HA) 39.9 0.00080
EPI291838 A/Minnesota/09/2010 (A/H3N2) segment 4 (HA) 39.9 0.00080
EPI246023 A/swine/Minnesota/02948/2009 (A/H3N2) segment 4 (HA) 39.9 0.00080

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Four human matches and one swine match in the entire database speaks volumes.

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A/Pennsylvania/40/2010 NA closely related to A/Wisconsin/12/2010 and A/Minnesota/09/2010.

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A/Pennsylvania/40/2010 PB2 sequence is exact match with A/Wisconsin/12/2010.

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CDC Comments On Swine H3N2 Cases In United States
Recombinomics Commentary 21:07
November 12, 2010


Two cases of human infection with a novel influenza A virus were reported: one case by the Wisconsin Department of Health Services and one case by the Pennsylvania Department of Health. Both patients were infected with a swine origin influenza A (H3N2) virus similar to the three other swine origin influenza A (H3N2) viruses previously identified in 2009 and 2010. The Wisconsin case reported contact with pigs in the week preceding symptom onset on September 8, 2010

http://www.recombinomics.com/News/11121 ... e_CDC.html

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CDC reports indicate the Wisconsin case (Wisconsin/12/2010) developed symptoms on September 8, 2010 and the report on the PA case indicated that symptoms began on September 6, 2010, but reporting was delayed because virus couldn't be culture. Then on a Sunday, April 17 - 7 months afterb the fact the CDC deposits ONE sample at GISAID with no fanfare and no indication the sample is an H3N2 triple reassortant (other samples were labeled as such). This sequence, Pennsylvania/40/2010, is virtually identical to the Wisconsin sequence.

Two cases developing symptoms 2 days apart in two seperate states with sequences looking to be nearly identical sounds much like the pandemic H1N1 outbreak in 2009 where the first two cases in southern California (samples collected 2 days apart) had nearly identical sequences with no prior contact.

The pager alert is looking to be increasingly significant and the 7 month delay in releasing the sequences continues to be suspect (as do the multiple comments from PA about novel H3N2 isolations).

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PB1 sequences of Pennsylvania/40/2010 and Wisconsin/12/2010 are IDENTICAL.

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PA sequences of Pennsylvania/40/2010 and Wisconsin/12/2010 differ at two positions (out of 1693).

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NP sequences from A/Pennsylvania/40/2010, A/Wiscosin/12/2010, and A/Minnesota/11/2010 are closely related.

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MP sequences from Pennsylvania/40/2010, Wisconsin/12/2010, and Minnesota/11/2010 are virtually identical.

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