Rhiza Labs FluTracker Forum

Hatefully sickening.

Phylogenetic tree of withheld sequences:

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www.twitter.com/hniman

Note widespread S188T (S188T in figure)

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www.twitter.com/hniman

Just to make sure I understand, these sequences are not from the current huge upsurge?

And what does S188T denote?

Thank you for your patience (previous and in advance).

Spread of H1N1 Immunological Escape Via S188T
Recombinomics Commentary 18:00
December 14, 2010

Recently released sequences (at GISAID) from the WHO Collaborating Centre for Reference and Research on Influenza in Australia have included samples collected in November, including A/VICTORIA/670/2010 which was collected on November 14, 2010.

These recent sequences can provide insight into the pH1N1 currently in circulation. The above isolate contains S188T as well as T1056C and G1403A (S454N) which is also in multiple recently released sequences (see list here and here), signal spread via clonal expansion.

S188T is near to position 190 and such flanking changes were seen in seasonal H1N1 associated with the global expansion of oseltamivir resistance, H274Y, where sequences had A193T plus one of more additional changes at flanking positions.

The emergence of pH1N1 with changes flanking position 190 raise concerns that such isolate will escape immunological detection and produce a new round of pH1N1 infections. Such vaccine breakthrough cases were noted in Australia and New Zealand in 2010. Recent data from the UK has noted the emergence of severe and fatal pH1N1 in previously healthy young adults.

Timely release of sequences from recent pH1N1 isolates, including severe cases in the UK would be useful.

No the sequences in BOLD are from the recent upsurge and contain S188T as predicted

http://www.recombinomics.com/News/12201 ... 8T_UK.html


H1N1 S188T Speads to Whitechapel United Kingdom
Recombinomics Commentary 19:00
December 20, 2010


The Health Protection Agency (HPA) has released four sets of sequences (at GISAID) from cases at the UK. The three most recent sequences were collected in October and November and the most recent case (2M) was collected November 28, 2010 (A/England/4880374/2010). This sequence had S188T (see list here) as well as associated changes, T1056C (see list here) and A1403G (see list here), indicating these polymorphisms were spreading via clonal expansion.

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www.twitter.com/hniman

The tree is from a publication on the cases in the UK. They released the tree but are WITHHOLDING the sequences.

http://www.eurosurveillance.org/ViewArt ... leId=19760

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www.twitter.com/hniman

''S188T is near to position 190 and such flanking changes were seen in seasonal H1N1 associated with the global expansion of oseltamivir resistance, H274Y, where sequences had A193T plus one of more additional changes at flanking positions.''

The great Tamiflu will shortly be resistant to this H1N1 strain.

Thats leaves only three viable antiviral alternatives. IV Zanamivir, Relenza and Super Relenza ( inavir - approved in Japan )

Really this is no surprise. The only surprise is it didnt happen sooner as Niman predicted early last year.

The 'experts' better become educated real soon re this evolving Tamiflu resistance or many people are going to die needlessly.

This is no spam. This is Life and Death.

Thanks to all for elucidations.

It's almost like, they're afraid?

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Praemonitus, Praemunitus..Forewarned is Forearmed.