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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 11:31 am 
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A mention in the WHO pager alert doesn't imply that each of these cases are current or signal a sustained human to human transmission will happen.

The most important questions remain undisclosed;
-Did IL case emerge at the same time that PA case did?
-Which are the contacts between them?
-Have they visited lately some farm or similar? Sequences will tell the truth.

We have to keep calm and follow closely the situation, that's all.


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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 11:42 am 
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niman wrote:
I have posted arguments on why the IL case is recent, as well as why both cases would be in in the same WHO pager alert.

I haven't seen much on the other side. I have seen some nonsense on other boards about infleunza changing all the time, while ignoring the fact that sustained transmission of swine H3N2 in humans has never been documented previously.


Well, your arguments on why these two cases are in the same WHO pager alert are relatively acceptable, but not absolutely true. I have to say the same; more data is needed. Not just the same reports cycling all over eastern Europe.

A sustained transmission of swine H3N2 would suggest a new pandemic has begun, but we don't know exactly what segments have re-assorted and even if H2H has occurred. That's the reason I don't like the title of this thread, almost assuring a pandemic is on its way.


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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 12:01 pm 
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niman wrote:


If a novel H3N2 with pandemic potential has clearly emerged it will take some time before CDC and the WHO announce this fact, risk communication are a great tool, you like it or not, and knowing that people out there is very skeptic or could caused the opposite; panic. It would be reasonable prepare a good response based on clear data.


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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 12:10 pm 
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Location: Pittsburgh, PA USA
CopitoSP wrote:
niman wrote:
I have posted arguments on why the IL case is recent, as well as why both cases would be in in the same WHO pager alert.

I haven't seen much on the other side. I have seen some nonsense on other boards about infleunza changing all the time, while ignoring the fact that sustained transmission of swine H3N2 in humans has never been documented previously.


Well, your arguments on why these two cases are in the same WHO pager alert are relatively acceptable, but not absolutely true. I have to say the same; more data is needed. Not just the same reports cycling all over eastern Europe.

A sustained transmission of swine H3N2 would suggest a new pandemic has begun, but we don't know exactly what segments have re-assorted and even if H2H has occurred. That's the reason I don't like the title of this thread, almost assuring a pandemic is on its way.

The CDC and WHO could move the situation ahead by simply giving the disease onset dates as well as a comment on the relationship between the two isolates. I suspect the cases are relatively close in time (with 1-2 months of each other) and have the same constellation of genes, which are closely related to each other.

I also would not be surprised if the CDC has found additional cases by now (and by now they should be able to say something more about the fatalities in Japan).

The pager alert assures the release of the info sooner rather than later, and I suspect the delay is based on discussion of strategies on how to present the news.

As far as the title is concerned. the initial post spelled out what was and wasn't known, which is likely to be very fluid and in need of a discussion thread (and this thread is under the "General Disussion" category).

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Last edited by niman on Thu Nov 11, 2010 12:20 pm, edited 1 time in total.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 12:13 pm 
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I wonder if the H3N2 outbreak in Japan is also related to this new strain. Reports describe a higher transmissibility than usual, a higher CFR and some patients who develop pneumonia and then deteriorate rapidly leading to death. Right now, we have 3 in serious condition.

Of note is that some adjacent prefectures are reaching epidemic levels.

Release of sequences of Akita cluster and novel H3N2 cases in the U.S is vital to take the necessary measures and prepare for another *pandemic*


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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 12:23 pm 
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Location: Pittsburgh, PA USA
CopitoSP wrote:
I wonder if the H3N2 outbreak in Japan is also related to this new strain. Reports describe a higher transmissibility than usual, a higher CFR and some patients who develop pneumonia and then deteriorate rapidly leading to death. Right now, we have 3 in serious condition.

Of note is that some adjacent prefectures are reaching epidemic levels.

Release of sequences of Akita cluster and novel H3N2 cases in the U.S is vital to take the necessary measures and prepare for another *pandemic*

Yes, Japan is a real concern, but distinguishing swine H3N2 from seasonal H3N2 is a challenge and more difficult than pH1N1 which was defined as influenza A positive and unable to subtype (initially to quickly determine the extent of spread). Swine H3N2 will subtype as human H3N2, and sequencing is straight forward, but limited to far fewer labs than those who can sub-type.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 1:48 pm 
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Location: Pittsburgh, PA USA
CopitoSP wrote:
niman wrote:
I have posted arguments on why the IL case is recent, as well as why both cases would be in in the same WHO pager alert.

I haven't seen much on the other side. I have seen some nonsense on other boards about infleunza changing all the time, while ignoring the fact that sustained transmission of swine H3N2 in humans has never been documented previously.


Well, your arguments on why these two cases are in the same WHO pager alert are relatively acceptable, but not absolutely true. I have to say the same; more data is needed. Not just the same reports cycling all over eastern Europe.

A sustained transmission of swine H3N2 would suggest a new pandemic has begun, but we don't know exactly what segments have re-assorted and even if H2H has occurred. That's the reason I don't like the title of this thread, almost assuring a pandemic is on its way.

The constellation of genes for swine H3N2 is pretty consistant. Although the H3 and N2 are human, they will likely be from the mid-1990's and cross reactivity will be limited because of the time difference as well as the evolution within swine.

It will spread relatively quickly because swine H3N2 in humans is rare (prior to the latest cases).

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 2:45 pm 
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H3N2 swine flu interview tonight at 10 PM EST

http://www.renseradio.com/listenlive.htm

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 3:01 pm 
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Location: Pittsburgh, PA USA
Commentary

http://www.recombinomics.com/News/11111 ... L_WHO.html

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Thu Nov 11, 2010 5:21 pm 
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http://ovsem.org/zdorove/v-ukrainu-idet ... -h3n2.html

Quote:
In Ukraine is a new flu virus - H3N2

"California," influenza, popularly known as pork, in Ukraine this year, doctors are regarded as seasonal. However, the expected emergence of a new strain of influenza H3N2, which will circulate the country.
But while experts advise not to panic. A new influenza virus H3N2, say like "California Flu", and in Ukraine already has a vaccine against it.

Grip H3N2
"The symptoms are the same as for ordinary flu, that is, fever, central nervous system, ie a person feeling unwell. May all be manifestations characteristic of normal influenza. That is, anything they do not differ, - said Deputy Director of the Ukrainian Centre for influenza and acute respiratory Irina Markovic.

In general, doctors predict, this year's seasonal influenza (not H3N2) pereboleyut about 4-5 million Ukrainians. While that of 2009, the number of bolevshih flu in Ukraine has reached almost 8 million people. However, in the near future influenza pandemic should not expect, experts say.
"If we take the previous week, the threshold incidence was 62 per 10,000 population. We have not reached before the epidemic threshold by more than 20%", - said Vladimir Zagorodnii (control on the organization of therapeutic and preventive care KSCA).
Meanwhile, the Ukrainian Ministry of Health urged vaccinated against influenza (including those against influenza H3N2). Make it convincing, it is necessary before winter. In Ukraine today, mark, registered 7 vaccines for vaccination against influenza. In particular, there is a vaccine against the new strain of influenza H3N2.
So beware of a new influenza strain H3N2!!!

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