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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Mon Nov 15, 2010 12:07 pm 
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Location: Pittsburgh, PA USA
niman wrote:
Top 100 PB1 matches


gb|EU604692.1| Influenza A virus (A/swine/OH/511445/2007(H1N1... 4021 0.0
gb|EU409945.1| Influenza A virus (A/swine/Ohio/24366/07(H1N1)... 4021 0.0
gb|GQ484357.1| Influenza A virus (A/swine/Kansas/77778/2007(H... 4002 0.0

The top two matches were sequences from the Huron county fair outbreak
http://www.recombinomics.com/News/07071001/pH1N1x2.html

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Mon Nov 15, 2010 12:09 pm 
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Posts: 56044
Location: Pittsburgh, PA USA
niman wrote:
Top 100 PA matches

gb|GQ484359.1| Influenza A virus (A/swine/Kansas/77778/2007(H... 3714 0.0
gb|EU604693.1| Influenza A virus (A/swine/OH/511445/2007(H1N1... 3709 0.0
gb|HM461817.1| Influenza A virus (A/swine/North Carolina/0202... 3672 0.0
gb|CY041846.1| Influenza A virus (A/swine/North Carolina/R08-... 3672 0.0
gb|HM461777.1| Influenza A virus (A/swine/Ohio/02026/2008(H1N... 3669 0.0
gb|CY035432.2| Influenza A virus (A/swine/Minnesota/SG-00239/... 3669 0.0
gb|EU743215.1| Influenza A virus (A/turkey/MN/366767/2005(H3N... 3669 0.0
gb|EU409947.1| Influenza A virus (A/swine/Ohio/24366/07(H1N1)... 3669 0.0

2007 Ohio isolates above are from the Huron county fair outbreak

http://www.recombinomics.com/News/07071001/pH1N1x2.html

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Mon Nov 15, 2010 12:21 pm 
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Location: Pittsburgh, PA USA
The A/Kansas/13/2009 internal genes match the sequences from the outbreak at the Huron county fair involving 2 dozen ILI-attendees and two confirmed infections A/Ohio/01/2007 and A/Ohio/02/2007.

This is a MAJOR smoking gun for the trH3N2 cases.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Mon Nov 15, 2010 1:36 pm 
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Joined: Wed Aug 19, 2009 10:42 am
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Location: Pittsburgh, PA USA
Commentary

http://www.recombinomics.com/News/11151 ... Huron.html

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Mon Nov 15, 2010 2:51 pm 
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Joined: Wed Aug 19, 2009 10:42 am
Posts: 56044
Location: Pittsburgh, PA USA
niman wrote:
The A/Kansas/13/2009 internal genes match the sequences from the outbreak at the Huron county fair involving 2 dozen ILI-attendees and two confirmed infections A/Ohio/01/2007 and A/Ohio/02/2007.

This is a MAJOR smoking gun for the trH3N2 cases.

The sequences above are from patient #4 and #5 in NEJM report on triple reassortants

http://www.nejm.org/action/showImage?do ... 12&iid=t01

Out of the 11 patients, these were the only example of two patients from the same outbreak.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Mon Nov 15, 2010 3:16 pm 
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Joined: Wed Aug 19, 2009 10:42 am
Posts: 56044
Location: Pittsburgh, PA USA
niman wrote:
niman wrote:
The A/Kansas/13/2009 internal genes match the sequences from the outbreak at the Huron county fair involving 2 dozen ILI-attendees and two confirmed infections A/Ohio/01/2007 and A/Ohio/02/2007.

This is a MAJOR smoking gun for the trH3N2 cases.

The sequences above are from patient #4 and #5 in NEJM report on triple reassortants

http://www.nejm.org/action/showImage?do ... 12&iid=t01

Out of the 11 patients, these were the only example of two patients from the same outbreak.

An H1N1 influenza A virus, A/swine/Ohio/24366/07, was isolated from pigs in an Ohio
county fair. Twenty-six people who came in contact with the infected pigs developed
respiratory disease and two of these people were laboratory confirmed as H1N1 by the
Centers for Disease Control and Prevention (CDC). The A/swine/Ohio/24366/07 virus we
isolated from swine was shown at the CDC to have 100% identical genome sequence to the human virus associated with the county fair.

http://download.thelancet.com/flatconte ... ogy-49.pdf

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Mon Nov 15, 2010 5:14 pm 
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Joined: Wed Aug 19, 2009 10:42 am
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Location: Pittsburgh, PA USA
Commentary

http://www.recombinomics.com/News/11151 ... demic.html

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Tue Nov 16, 2010 9:18 am 
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Posts: 926
Dr Niman, what's the go with D225G and Tamiflu resistance in both the current H3N2 and this new Frankenstein swine mix one?


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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Tue Nov 16, 2010 10:02 am 
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Location: Pittsburgh, PA USA
Dingo wrote:
Dr Niman, what's the go with D225G and Tamiflu resistance in both the current H3N2 and this new Frankenstein swine mix one?

Tamiflu resistance in H3N2 will not be a problem because it has N2 (although the three isolates from the farm workers in Sasketchewan in 2009 were infected with an H1N1 triple reassortant with H1 and N1 from Brisbane/59-like H1N1, which have H274Y).

However, Kansas/13 does have D225G.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Tue Nov 16, 2010 10:39 am 
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Joined: Sat Jan 30, 2010 2:44 am
Posts: 926
niman wrote:
Dingo wrote:
Dr Niman, what's the go with D225G and Tamiflu resistance in both the current H3N2 and this new Frankenstein swine mix one?

Tamiflu resistance in H3N2 will not be a problem because it has N2 (although the three isolates from the farm workers in Sasketchewan in 2009 were infected with an H1N1 triple reassortant with H1 and N1 from Brisbane/59-like H1N1, which have H274Y).

However, Kansas/13 does have D225G.


So "under the bonne"t this new trH3N2 could acquire some nasty pH1N1 D225 mutations?


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