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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Tue Nov 16, 2010 2:10 pm 
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Dingo wrote:
niman wrote:
Dingo wrote:
Dr Niman, what's the go with D225G and Tamiflu resistance in both the current H3N2 and this new Frankenstein swine mix one?

Tamiflu resistance in H3N2 will not be a problem because it has N2 (although the three isolates from the farm workers in Sasketchewan in 2009 were infected with an H1N1 triple reassortant with H1 and N1 from Brisbane/59-like H1N1, which have H274Y).

However, Kansas/13 does have D225G.


So "under the bonne"t this new trH3N2 could acquire some nasty pH1N1 D225 mutations?

It already has D225G, so no acquisitions are necessary.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Tue Nov 16, 2010 11:36 pm 
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The NP gene has an origin that differs from the other internal genes (which are from Huron fair). Thus, the virus has H3 and N2 from one source, NP from another, and the remaining five from the Huron fair.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Tue Nov 16, 2010 11:44 pm 
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niman wrote:
The NP gene has an origin that differs from the other internal genes (which are from Huron fair). Thus, the virus has H3 and N2 from one source, NP from another, and the remaining five from the Huron fair.

The NP gene is closely related to A/swine/NC/2023/2008 followed by A/swine/MN/SG-00239/2007, A/swine/MN/02011/2008. A/swine/MO/02060/2008 A/swine/NE/02013/2008 (these are H1N1 and H1N2). It is NOT close to the Huron fair-like sequences.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Wed Nov 17, 2010 9:33 am 
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Back in the mid 90's D225G was common in seasonal H3N2 (current seasoinal H3N2 has D225N).

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Wed Nov 17, 2010 10:28 am 
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niman wrote:
Back in the mid 90's D225G was common in seasonal H3N2 (current seasoinal H3N2 has D225N).


what effect did that have? Ukraine style?


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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Wed Nov 17, 2010 10:47 am 
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Commentary

http://www.recombinomics.com/News/11171 ... Novel.html

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Wed Nov 17, 2010 11:10 am 
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Dingo wrote:
niman wrote:
Back in the mid 90's D225G was common in seasonal H3N2 (current seasoinal H3N2 has D225N).


what effect did that have? Ukraine style?

No, D225G in H3N2 isn't as severe as D225G in H1N1.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Wed Nov 17, 2010 8:30 pm 
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CDC has released the sequences at GISAID (A/Wisconsin/12/2010, A/Pennsylvania/14/2010, A/Minnesota/09/2010, A/Iowa/16/2009). At least two have seasonal H3 and N2).

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Wed Nov 17, 2010 9:00 pm 
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niman wrote:
CDC has released the sequences at GISAID (A/Wisconsin/12/2010, A/Pennsylvania/14/2010, A/Minnesota/09/2010, A/Iowa/16/2009). At least two have seasonal H3 and N2).

All have D225G in H3 and all have the same unusual NP gene.

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 Post subject: Re: Swine H3N2 Pandemic
PostPosted: Wed Nov 17, 2010 9:04 pm 
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All five have PB1 E618D.

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