Rhiza Labs FluTracker Forum

With the triple re-assortment.

Is the novel H3N2 a result of human H3 and H2 replacing the H1 and N1 in the pH1N1 virus.

Does this make it a triple re-assortment, I guess it does if pH1N1 was a triple?

Swine was originally H1N1 (classical swine). In the 1990's it first became a double reassortant when it aquired human H3, N2, and PB1. It then acquired avian PB2 and PA to become a triple reassortant in the 1990's. The swapping of the H and N produced the pH1N1 (with swine H and N) triple reassortant. Various combinations of H and N swaps produce H1 tripled reassortants (with human or swine H and N's).

New H3N2 triple reassortants just replace the H and N with human H3 and N2.

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Georgia, Tbilisi, Nov. 11 / Trend N.Kirtzkhalia /

The World Health Organization has sent a warning to Georgia about a swine flu mutation.

However, the Georgian National Center for Disease Control said that the country faces no danger as of yet, and the warning was only sent to specialists via private channels.

The warning indicates that the H3N2 virus has been found in two people. Experts believe that that the H3N2 is a mutation of the swine flu and contains three circulating viruses.



The first case of the new influenza was detected in a 46-year-old man in Pennsylvania.

The swine flu killed 27 people in Georgia last year.

http://en.trend.az/news/politics/1780389.html

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Human H3 and N2 in pH1N1 would be a triple reassortant, but there are many other swine triple reassortants (with swine or human H1 and N1/N2) that could acquire human H3 and N2.

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www.twitter.com/hniman

From tomorrow's MMWR

Novel influenza A virus infections†††
1
2
0
43,774
2
4
NN
NN
PA (1)
http://www.cdc.gov/mmwr/preview/mmwrhtm ... mm5944md_w

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www.twitter.com/hniman

Thanks for that explanation.

As we know you can get 1 or 2 cases, then thousands in a short time.

Going to be a busy time ahead if it takes off, I do think WHO will be restraint for a while, to monitor severity and transmission.

It is the CDC who is hanging things up. They have acknowledged the 46M in Pennsylvania. The key question is the 7 month old in Illinois. If that child is current and doesn't link directly to PA, then a swine H3N2 pandemic is VERY likely.

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Chief state sanitary doctor Gennady Onishchenko of Russia has claimed that the World Health Organization’s alert system has already received worrying reports that two U.S. citizens were diagnosed virus H3N2 - mutation of influenza of swine origin.

"It consists of three" pieces "of the former viruses, but differs by its genetic structure. We are studying this information,” Onishchenko said.

The first case of a new flu was detected in a 7-month-old baby in Illinois, the second one in a 46-year-old man in Pennsylvania.

Source: http://abc.az/eng/news/main/49337.html

If there are two current swine H3N2 cases, then there already are thousands. They just haven't been identified.

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This suggests that novel H3N2 cases are separated in time. A pandemic is unlikely, then.

Sequences of these two cases have to be released.