Rhiza Labs FluTracker Forum

The Higher Institute of Health has documented the first case of transmission of variant changed world of the pandemic virus. This is the infamous dell'emagglutinina the gene mutation D225G, D222G also that according to the numbering system adopted, suspected of facilitating the access of the virus into the depths of the lungs. The news was published at the bottom page which shows the contribution of the Institute for pandemic flu.


As a world premiere is likely that the Italian researchers National Influenza Center of the Department of Infectious Diseases, Parasitic and immune-mediated

I have notified the World Health Organization and have posted an article a few international scientific journal. Recall that after the announcement of the discovery of mutations in France, the ISS had initiated retrospect viral sequences isolated in Italy and found the mutation in samples of a young man - as told by Ferruccio Fazio - was among the first cases serious enough to be hospitalized at Monza, where it operates one of the groups leading Italian expert in the use of extracorporeal membrane oxygenation for the treatment of respiratory distress syndrome. La Gazzetta di Parma had put two and two forward the suspicion that the case concerned the mutation of the Emilian city boy who had fallen ill in August and had already granted several interviews to newspapers (he himself has told his story to Republic). But for privacy reasons health authorities chose not to confirm the identity. Researchers ISS then passed to check the mutation in samples of the only family member who was infected by the young. Again they found the mutation. This is bad news, because it shows that the mutated virus is capable of transmitting from one individual to another. The good news, however, is that the family has had an infected with a classical course, which has degenerated into pneumonia. So this mutation alone does not seem able to unbalance the prognosis in the sense ominous. Were tested atver 10 people (family, friends and medical staff) who were exposed to two patients during the acute phase of disease without developing any symptoms of influenza among themselves to see if there were some cases asymptomatic. None of these people, however, has ever contracted the virus. The ISS adds that the mutation was not detected in any of the sequences obtained from the other cases studied (over 70 patients with influenza H1N1v from different Italian regions).

http://www.nuovainfluenzah1n1.info/ulti ... utato.html

First of all, if they won't release identities, the whole story remains suspicious.

Secondly, if it can be documented, the story might indicate the variant can spread within families--nothing more.

I think that the public acknowledgement that the ‘mutation’ is transmittable among humans
by an official health agency is a significative improvement to the public perception of pandemic H1N1.

Albeit this possibility [H1N1 polymorphysm transmission] is take for granted by many members
of this forum, it is probably far from a medical community consensus.

According to WHO:
28 December 2009 [… …]

The D222G substitution has been detected in virus isolates from around 20 countries,
areas, and territories in the Americas, Asia, Europe, and Oceania. These changes have
been found since April 2009 but not been associated with temporal or geographical
clustering, strongly suggesting the mutation in these viruses have occurred sporadically
as opposed to the emergence and sustained transmission of a variant virus.
(Preliminary review of D222G amino acid substitution in the haemagglutinin of
pandemic influenza A (H1N1) 2009 viruses)
http://www.who.int/csr/resources/public ... index.html

See also topic discussing this document:
WHO GAR D222G preliminary review
viewtopic.php?f=26&t=4342

Please. The identity of the index case is known. You are posting nonsense.

For three days walking on its legs Fabio Ferri, the 24 year old Parma, first serious cases of H1N1 in Italy, saved by the care the hospital San Gerardo of Monza in September. And only now realizes that he had won the battle more important.

It's the end of a long ordeal. How does it feel?
"As one who has been given a second life. Simply put, are a miracle. I never cried in my life but now when I hear that someone can not do it, is struggling to hold back sobs. "

What do you remember about your case?
"Everything, but it's as if my story was divided into two parts."

We leave the shelter of Parma.
"On 23 August I started to feel unwell, but after the first visit to the doctors I was sent home. But things are worse now, it's shelter. I could not breathe, I thought I would die. They told me that they should sleep. From there it's dark. "

Until when?
"I do not know how to say exactly, I was told that I was in a pharmacological coma for 15 days. I wanted to fight, I realized that to survive I had to do something extraordinary. It was as if I were attached to something that was in and out of me. Perhaps it was the presence of my mother and my girl. "

These are the days when they separated dall'Ecmo, the machine that was breathing in his place.
"I felt that something was happening, but I did not understand."

When WHO adds the qualifier "sustained" with regard to transmission, it means they have seen transmission, so they have to add sustained so they can make the denial. Most WHO press releases are best interpreted by the qualifiers they use.

From your opening post:
"But for privacy reasons health authorities chose not to confirm the identity."

Posting reflections based on YOUR post is not nonsense, Henry.

Thank you for posting additional information afterward.

The media interviewed the case and posted his story and identity. You continue to post nonsense. It is common for health agencies to refuse to confirm identities, but easy for investigative reporters to match symptoms, dates, and locations, especially when the cases is the first severe case in Italy and the person interviewed was on an ECMO machine and in an induced coma for 15 days (the additional information I posted was linked to the story I linked).

Data analysis 101. In Ukraine, D225G or D225N was in 8 of 8 fatal cases from the same sub-clade. These fatal cases were unreleated to each other and in four seperate regions in Ukraine (Ternopil, Lviv, Kyiv city, Chernihiv). Fatal cases with D225G or D255N in the same sub-clade were in three regions of Russia, north of Ukraine.

D225G transmits (quite obviously).

The first post of this thread quotes an Italian magazine entitled Darwin (*).
For the sake of clarity, I append the oficial Italian Ministry of Health December 22 press release:

Italian Ministry of Health - Higher Institute of Health

Update on the pandemic influenza virus mutation D222G in A/H1N1v Italy
(ISS December 22, 2009)

"Following retrospective examination of the sequences of strains of influenza virus pandemic A/H1N1v by the
National Influenza Center of the Department of Infectious Diseases, Parasitic and immune-mediated, we
have identified two cases in total, bound together, in which a mutation was present that led to the
replacement of an amino acid in hemagglutinin (D222G). The infection was transmitted from a patient
suffering from a severe viral pneumonia in a family, but he has since developed a flu syndrome with benign course.

Both viruses were susceptible to the neuraminidase inhibitors, including Tamiflu. Another 10 people (family,
friends and health workers) exposed to two patients during the acute phase of disease did not develop any
symptoms. Moreover, the mutation was not detected in any of the sequences obtained from more than 70
patients with influenza A/H1N1v from various Italian regions. The mutation in question is then transmitted
but the efficiency of transmission seems to be limited, moreover, the difference in disease severity in the
two cases identified in Italy does not support a strong association with severe influenza."

Italian Ministry of Health - Higher Institute of Health
[ISS (Istituto Superiore di Sanità), Ministero della Salute]
http://www.iss.it/pres/prim/cont.php?id ... g=1&tipo=6

(*) NOTE: The Darwin magazine flu section – named DarwinFlu - has 4 interesting “lemmas” [in Italian] near the logo:
- It is not a normal influenza
- It is not like the Spanish [flu].
- It is not the Appocalypse
- It is not a mediatic epidemic.

Commentary

http://www.recombinomics.com/News/01171 ... uster.html