FluView Week 1

niman · **Posted:** Fri Jan 15, 2010 4:30 pm

wotan wrote:

The novel influenza A virus infection was not reported in the MMWR...

These swine jumps to human, when limited are usually reported in the CDC weekly flu updates.

pw123 · **Joined:** Sat Oct 17, 2009 5:03 pm **Posts:** 78

wotan wrote:

Is the swine H3N2 similar enough to the human variety for the seasonal vaccine to convey protection?

I am wondering about this also.

niman · **Posted:** Fri Jan 15, 2010 5:06 pm

wotan wrote:

[quote="niman'] Humans infected with swine influenza without contact with swine is a concern. Swine H3N2 has a human H3 and a human N2 and is a triple reassortant. I don't think that routine sub-typing will distiguish seasonal H3N2 from swine H3N2, although at this time there does not appear to be seasonal H3N2 in circulation.[/quote]

Is the swine H3N2 similar enough to the human variety for the seasonal vaccine to convey protection?[/quote]

The swine H3N2 would be closely related to human H3N2 from 1996, so there would be protection, but it would be limited.

niman · **Posted:** Fri Jan 15, 2010 5:44 pm

Commentary

http://www.recombinomics.com/News/01151 ... _Iowa.html

spentitall · **Joined:** Wed Nov 04, 2009 2:14 am **Posts:** 337

Here's a link that gives a little more info. about the H3N2 case.

http://www.winnipegfreepress.com/life/h ... 96832.html

Quote:

TORONTO - Another new swine flu virus has made the leap to humans, though U.S. officials say it seems almost certain the virus hit a dead end.

The Centers for Disease Control reported Friday that a child from Iowa became infected with a new swine flu virus in September, though the case didn't come to light until November.

The unnamed boy didn't need to be hospitalized and recovered fully from the illness.

Testing later showed he'd been infected with a swine influenza virus of the H3N2 subtype, different both from the pandemic H1N1 virus and from the seasonal H3N2 viruses that have been circulating in people for decades.

Human cases of infection with swine influenza viruses happen from time to time. Often, though not always, these infections are seen in people who work on pig farms or in proximity to swine herds.

Last summer officials in Saskatchewan spotted a different swine H1N1 virus in two hog farm workers. As in the case of the boy in Iowa, that virus seemed to stop spreading.

"While these cases are rare, they're not unheard of," Tom Skinner, a spokesman for the CDC, said from Atlanta, Ga.

"We do detect them from time to time and it's important for us to investigate, which happened in this case. And luckily there wasn't any evidence of sustained person-to-person transmission."

It isn't clear how the boy became infected with the virus. He had no known contact with pigs, an eerie echo of the emergence last spring of the pandemic H1N1 virus. H1N1 was first spotted in two children from California who had had no contact with pigs or with each other.

"It was a child, and yeah, very similar to the circumstances that occurred last spring," Skinner said of the Iowa case.

He said the fact that the investigation turned up no other cases and that some time has since elapsed suggests there isn't any ongoing spread. "I think if there was other transmission going on associated with this case we would have picked it up and we haven't."

There are a variety of influenza viruses circulating among pigs. According to the CDC, the four main types currently found are H1N1, H1N2, H3N2 and H3N1 viruses.

Prior to the pandemic, a human case of swine flu in the United States was discovered every year or two. But in the three years or so before the pandemic, 12 cases were found.

niman · **Posted:** Sat Jan 16, 2010 5:48 am

spentitall wrote:

Here's a link that gives a little more info. about the H3N2 case.

http://www.winnipegfreepress.com/life/h ... 96832.html

Quote:

TORONTO - Another new swine flu virus has made the leap to humans, though U.S. officials say it seems almost certain the virus hit a dead end.

The Centers for Disease Control reported Friday that a child from Iowa became infected with a new swine flu virus in September, though the case didn't come to light until November.

Quote:

The almost certain dead end is nonsense. By November the virus could have spread far from the above case. Family members would have recovered, so the number infected remains unknown (and the report doesn't cite how many had symptoms). The "almost certain" depends on negative data and since no source is identified, the virus could be widespread. Testing of mild cases is minimal and Iowa had media stories in the sping on hundreds of symptomatic cases who were not tested.

Gator Flu Watcher · **Joined:** Sun Oct 11, 2009 4:44 pm **Posts:** 446

niman wrote:

The almost certain dead end is nonsense. By November the virus could have spread far from the above case. Family members would have recovered, so the number infected remains unknown (and the report doesn't cite how many had symptoms). The "almost certain" depends on negative data and since no source is identified, the virus could be widespread. Testing of mild cases is minimal and Iowa had media stories in the sping on hundreds of symptomatic cases who were not tested

Wait! If seasonal H3N2 is not widespread because of pH1N1's dominance, then how come swine H3N2 can be widespread?

niman · **Posted:** Sat Jan 16, 2010 2:11 pm

Gator Flu Watcher wrote:

niman wrote:

The almost certain dead end is nonsense. By November the virus could have spread far from the above case. Family members would have recovered, so the number infected remains unknown (and the report doesn't cite how many had symptoms). The "almost certain" depends on negative data and since no source is identified, the virus could be widespread. Testing of mild cases is minimal and Iowa had media stories in the sping on hundreds of symptomatic cases who were not tested

Wait! If seasonal H3N2 is not widespread because of pH1N1's dominance, then how come swine H3N2 can be widespread?

Widespread as in the start of a H3N2 pandemic (during an H1N1 pandemic).
The CDC says it has already dead ended, which has no scientific basis.

Gator Flu Watcher · **Joined:** Sun Oct 11, 2009 4:44 pm **Posts:** 446

niman wrote:

Widespread as in the start of a H3N2 pandemic (during an H1N1 pandemic).
The CDC says it has already dead ended, which has no scientific basis

Yeah, I totally get the CDC's being ridiculous.

I don't get your drift (no pun intended) on the swine H3N2. Are you saying this could possibly be the start of a new pandemic? Seems like it would take a while for it to evolve though given pH1N1's voracity. But then there's always recombination.

niman · **Posted:** Sat Jan 16, 2010 8:47 pm

INFLUENZA H3N2, NEW, SWINE, HUMAN - UNITED STATES OF AMERICA: (IOWA)
********************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Fri 15 Jan 2010
Source: Yahoo Canada News, Canadian Press report [edited]
<http://ca.news.yahoo.com/s/capress/100115/national/flu_new_swine_flu>

U.S. CDC reports finding single case of a new swine flu; no sustained spread
----------------------------------------------------------------------------
Another new swine flu virus has made the leap to humans, though U.S.
officials say it seems almost certain the virus hit a dead end. The
Centers for Disease Control and Prevention (CDC) reported Friday [15
Jan 2010] that a child from Iowa became infected with a new swine flu
virus in September [2009], though the case didn't come to light until
November. The unnamed boy didn't need to be hospitalized, and he
recovered fully from the illness. Testing later showed he'd been
infected with a swine influenza virus of the H3N2 subtype,
*** different both from the pandemic H1N1 virus and from the seasonal
H3N2 viruses that have been circulating in people for decades.*** [see
ProMED archives listed below]. Human cases of infection with swine
influenza viruses happen from time to time. Often, though not always,
these infections are seen in people who work on pig farms or in
proximity to swine herds.

Last summer officials in Saskatchewan spotted a different swine H1N1
virus in 2 hog farm workers. As in the case of the boy in Iowa, that
virus seemed to stop spreading. "While these cases are rare, they're
not unheard of," Tom Skinner, a spokesman for the CDC, said from
Atlanta, Georgia. "We do detect them from time to time and it's
important for us to investigate, which happened in this case. And
luckily there wasn't any evidence of sustained person-to-person
transmission."

It isn't clear how the boy became infected with the virus. He had no
known contact with pigs, an eerie echo of the emergence last spring of
the pandemic (H1N1) 2009 virus. [Pandemic] H1N1 was 1st spotted in 2
children from California who had had no contact with pigs or with each
other. "It was a child, and yeah, very similar to the circumstances
that occurred last spring," Skinner said of the Iowa case. He said the
fact that the investigation turned up no other cases and that some
time has since elapsed suggests there isn't any ongoing spread. "I
think if there was other transmission going on associated with this
case we would have picked it up and we haven't."

There are a variety of influenza viruses circulating among pigs.
According to the CDC, the 4 main types currently found are H1N1, H1N2,
H3N1 and H3N2 viruses. Prior to the pandemic, a human case of swine
flu in the United States was discovered every year or 2. But in the 3
years or so before the [H1N1] pandemic, 12 cases were found.

[Byline: Helen Branswell]

--
Communicated by:
ProMED-mail
<promed@promedmail.org>

[Transmission of swine influenza viruses to humans is an exceptional
event, and uniquely in the case of the pandemic (H1N1) 2009
swine-derived virus, it became easily transmissible from human to
human in an unrestricted manner. Additionally, swine have been
hypothesized to be intermediates in the process of adaptation of avian
influenza viruses for transmission to other mammals.

Fortunately in the case of the child in Iowa, onward transmission of
the swine H3N2 virus has not occurred. What is exceptional about this
case is that no evidence of contact of the child with swine has been
discovered, perhaps suggesting an additional intermediate host may
have been involved.

The HealthMap/ProMED-mail interactive map of the United States of
America can be used to locate the state of Iowa:
<http://healthmap.org/r/009V>. - Mod.CP]

[see also:
2009
----
Influenza, H3N2, mink - Denmark, OIE 20091023.3660
Influenza A (H3N2), swine, human - USA: (KS) 20090808.2812
Influenza pandemic (H1N1) 2009 (23): (China, Taiwan), co-circ. H3N2
20090802.2713
Seasonal influenza (H3N2) virus - potential vaccine mismatch 20090724.2623
Influenza A (H1N1) - worldwide (11): coincident H3N2 variation 20090505.1679
2008
----
Influenza, seasonal, H3N2 - UK 20081231.4126
2005
----
Avian influenza, H3N2, turkeys - USA (NC) 20050208.0432
2004
----
Influenza A (H3N2), variant strain 20041024.2879
Avian influenza, H3N2, poultry - USA (MO) 20040916.2577
2003
----
Influenza A (H3N2) - Northern Hemisphere (06) 20031231.3180
Influenza A (H3N2) - Northern Hemisphere (05) 20031224.3125
Influenza A (H3N2) - Northern Hemisphere (04) 20031218.3088
Influenza A (H3N2) - Northern Hemisphere (03) 20031211.3037
Influenza A (H3N2) - Northern Hemisphere (02) 20031210.3034
Influenza A (H3N2) - Northern Hemisphere 20031206.2998
Influenza A (H3N2) virus - Israel 20031029.2698
2000
----
Influenza A H3N2 - World roundup 20000111.0040
1999
----
Influenza H3N2, pig to human? - China (Hong Kong) 19991020.1876
1998
----
Influenzavirus A (H3N2): antigenic variations 19980118.0150
1996
----
Influenza A(H3N2) - New Zealand (3) 19960712.1249
Influenza A(H3N2) - New Zealand (4) 19960712.1248
Influenza A(H3N2) - New Zealand: Correction (2) 19960711.1242
Influenza A(H3N2) - New Zealand (2) 19960711.1238
Influenza A(H3N2) - New Zealand: Correction 19960711.1237
Influenza A(H3N2) - New Zealand 19960710.1233]
....................jw/cp/ejp/jw

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