Rhiza Labs FluTracker Forum

New sequences from Norway have been released. However, a VERY quick look found 5 sequences with D225E and no D225G. Thus, the media reports claimimg D225G in Norway may be in error.

Here are Genbank sequences with D225E

gb|CY052015.1| Influenza A virus (A/Norway/4023/2009(H1N1)) s... 40.1 0.048
gb|CY052007.1| Influenza A virus (A/Norway/3478/2009(H1N1)) s... 40.1 0.048
gb|CY051991.1| Influenza A virus (A/Norway/3059/2009(H1N1)) s... 40.1 0.048
gb|CY051987.1| Influenza A virus (A/Norway/2690/2009(H1N1)) s... 40.1 0.048
gb|CY051986.1| Influenza A virus (A/Norway/2674/2009(H1N1)) s... 40.1 0.048
gb|CY051982.1| Influenza A virus (A/Catalonia/S1761/2009(H1N1... 40.1 0.048
gb|CY051976.1| Influenza A virus (A/Catalonia/S1758/2009(H1N1... 40.1 0.048
gb|CY051964.1| Influenza A virus (A/Catalonia/S1748/2009(H1N1... 40.1 0.048
gb|CY051955.1| Influenza A virus (A/Catalonia/S1698/2009(H1N1... 40.1 0.048
gb|CY051940.1| Influenza A virus (A/Catalonia/S1674/2009(H1N1... 40.1 0.048
gb|CY051937.1| Influenza A virus (A/Catalonia/S1672/2009(H1N1... 40.1 0.048
gb|GU214058.1| Influenza A virus (A/Serbia/3547/2009(H1N1)) s... 40.1 0.048
gb|CY050319.1| Influenza A virus (A/Catalonia/S1641/2009(H1N1... 40.1 0.048
gb|CY050316.1| Influenza A virus (A/Catalonia/S1637/2009(H1N1... 40.1 0.048
gb|CY050313.1| Influenza A virus (A/Catalonia/S1632/2009(H1N1... 40.1 0.048
gb|CY050307.1| Influenza A virus (A/Catalonia/S1606/2009(H1N1... 40.1 0.048
gb|CY050304.1| Influenza A virus (A/Catalonia/S1605/2009(H1N1... 40.1 0.048
gb|CY050301.1| Influenza A virus (A/Catalonia/S1604/2009(H1N1... 40.1 0.048
dbj|AB530488.1| Influenza A virus (A/Nagasaki/HA-44/2009(H1N1... 40.1 0.048
gb|CY049742.1| Influenza A virus (A/Catalonia/S1592/2009(H1N1... 40.1 0.048
gb|CY049736.1| Influenza A virus (A/Catalonia/S1587/2009(H1N1... 40.1 0.048
gb|CY049728.1| Influenza A virus (A/Catalonia/S1545/2009(H1N1... 40.1 0.048
gb|CY049707.1| Influenza A virus (A/Catalonia/S1479/2009(H1N1... 40.1 0.048
gb|CY049704.1| Influenza A virus (A/Catalonia/S1478/2009(H1N1... 40.1 0.048
gb|CY049051.1| Influenza A virus (A/Catalonia/S1436/2009(H1N1... 40.1 0.048
gb|CY049027.1| Influenza A virus (A/Catalonia/S1379/2009(H1N1... 40.1 0.048
gb|CY049024.1| Influenza A virus (A/Catalonia/S1369/2009(H1N1... 40.1 0.048
gb|CY049018.1| Influenza A virus (A/Catalonia/S1350/2009(H1N1... 40.1 0.048
gb|CY049015.1| Influenza A virus (A/Catalonia/S1333/2009(H1N1... 40.1 0.048
gb|CY049012.1| Influenza A virus (A/Catalonia/S1331/2009(H1N1... 40.1 0.048
gb|CY049003.1| Influenza A virus (A/Catalonia/S1304/2009(H1N1... 40.1 0.048
gb|CY049000.1| Influenza A virus (A/Catalonia/S1300/2009(H1N1... 40.1 0.048
gb|CY047307.1| Influenza A virus (A/Catalonia/S1286/2009(H1N1... 40.1 0.048
gb|CY047290.1| Influenza A virus (A/Catalonia/S1273/2009(H1N1... 40.1 0.048
gb|CY047287.1| Influenza A virus (A/Catalonia/S1272/2009(H1N1... 40.1 0.048
gb|CY047278.1| Influenza A virus (A/Catalonia/S1269/2009(H1N1... 40.1 0.048
gb|CY047269.1| Influenza A virus (A/Catalonia/S1265/2009(H1N1... 40.1 0.048
gb|CY047266.1| Influenza A virus (A/Catalonia/S1260/2009(H1N1... 40.1 0.048
gb|CY047263.1| Influenza A virus (A/Catalonia/S1254/2009(H1N1... 40.1 0.048
gb|CY047257.1| Influenza A virus (A/Catalonia/S1249/2009(H1N1... 40.1 0.048
gb|CY047254.1| Influenza A virus (A/Catalonia/S1248/2009(H1N1... 40.1 0.048
gb|CY047243.1| Influenza A virus (A/Catalonia/S1237/2009(H1N1... 40.1 0.048
gb|CY047240.1| Influenza A virus (A/Catalonia/S1236/2009(H1N1... 40.1 0.048
gb|CY047230.1| Influenza A virus (A/Catalonia/S1227/2009(H1N1... 40.1 0.048
gb|CY047227.1| Influenza A virus (A/Catalonia/S1222/2009(H1N1... 40.1 0.048
gb|CY047221.1| Influenza A virus (A/Catalonia/S1215/2009(H1N1... 40.1 0.048
gb|CY047215.1| Influenza A virus (A/Catalonia/S1209/2009(H1N1... 40.1 0.048
gb|CY047203.1| Influenza A virus (A/Catalonia/S1205/2009(H1N1... 40.1 0.048
gb|CY047200.1| Influenza A virus (A/Catalonia/S1199/2009(H1N1... 40.1 0.048
gb|CY047188.1| Influenza A virus (A/Catalonia/S1187/2009(H1N1... 40.1 0.048
gb|CY047185.1| Influenza A virus (A/Catalonia/S1183/2009(H1N1... 40.1 0.048
gb|CY047182.1| Influenza A virus (A/Catalonia/S1182/2009(H1N1... 40.1 0.048
gb|CY047164.1| Influenza A virus (A/Catalonia/S1165/2009(H1N1... 40.1 0.048
gb|CY047158.1| Influenza A virus (A/Catalonia/S1161/2009(H1N1... 40.1 0.048
gb|CY047137.1| Influenza A virus (A/Catalonia/S1120/2009(H1N1... 40.1 0.048
gb|GQ485661.1| Influenza A virus (A/Almati/01/2009(H1N1)) seg... 40.1 0.048
gb|GQ457519.1| Influenza A virus (A/Changsha/78/2009(H1N1)) s... 40.1 0.048
gb|GQ457514.1| Influenza A virus (A/California/25/2009(H1N1))... 40.1 0.048
gb|GQ422381.1| Influenza A virus (A/Milan/83/2009(H1N1)) segm... 40.1 0.048
gb|GQ422380.1| Influenza A virus (A/Milan/80/2009(H1N1)) segm... 40.1 0.048
gb|GQ421203.1| Influenza A virus (A/Ancona/05/2009(H1N1)) seg... 40.1 0.048
gb|GQ387430.1| Influenza A virus (A/Catalonia/378/2009(H1N1))... 40.1 0.048
gb|GQ387382.1| Influenza A virus (A/Italy/172/2009(H1N1)) hem... 40.1 0.048
gb|GQ365446.1| Influenza A virus (A/Sapporo/1/2009(H1N1)) seg... 40.1 0.048
gb|GQ355305.1| Influenza A virus (A/Catalonia/387/2009(H1N1))... 40.1 0.048
gb|GQ351314.1| Influenza A virus (A/Hong Kong/2369/2009(H1N1)... 40.1 0.048
gb|GQ258700.1| Influenza A virus (A/Athens/893/2009(H1N1)) se... 40.1 0.048
gb|GQ249333.1| Influenza A virus (A/Paris/2591/2009(H1N1)) se... 40.1 0.048
gb|GQ160534.1| Influenza A virus (A/New Jersey/01/2009(H1N1))... 40.1 0.048

I have looked a little harder and only see the five isolates with D225E (and no D225G).

[quote='kat']Swedish Infectious Diseases Institute (SMI) about the new variant:

http://translate.google.se/translate?js ... l=sv&tl=en

In Sweden, the variant was detected in two patients who were cared for in ECMO in July and in August.[/quote]


Niman,
kat placed a link on the Sweden thread to 2 cases in Sweden that were thought to be the same as what Norway found.

[If the link posted above doesn't work, then go to the recent posts on Sweden's thread and it works there.]

Maybe they haven't released everything?

Only well qualified scientists should be making the media reports, and concurrently with total full disclosure sequence releases.

The list looks pretty comprehensive with samples colled from May through October. The sequences were deposited yesterday. I would say this all that they have.

One isolate, A/Norway/2924/2009, is a mixture of D225G and wild type.

LOCUS ACZ45011 566 aa linear VRL 23-NOV-2009
DEFINITION hemagglutinin [Influenza A virus (A/Norway/2924/2009(H1N1))].
ACCESSION ACZ45011
VERSION ACZ45011.1 GI:269819807
DBSOURCE accession CY051989.1
KEYWORDS .
SOURCE Influenza A virus (A/Norway/2924/2009(H1N1))
ORGANISM Influenza A virus (A/Norway/2924/2009(H1N1))
Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
Influenzavirus A.
REFERENCE 1 (residues 1 to 566)
AUTHORS Hungnes,O., Dudman,S.G. and Kilander,A.
TITLE Pandemic Influenza A(H1N1) Viruses in Norway, 2009
JOURNAL Unpublished
REFERENCE 2 (residues 1 to 566)
AUTHORS Hungnes,O., Dudman,S.G. and Kilander,A.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2009) National Influenza Centre, Dept.of
Virology, Div. of Infectious Disease Control, Norwegian Inst. of
Public Health, P.O.Box 4404 Nydalen, Oslo 0403, Norway
COMMENT Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..566
/organism="Influenza A virus (A/Norway/2924/2009(H1N1))"
/strain="A/Norway/2924/2009(H1N1)"
/serotype="H1N1"
/isolation_source="gender:F; age:40 yr"
/host="human"
/db_xref="taxon:694204"
/segment="4"
/lab_host="MDCK1 passage(s)"
/country="Norway: Sor-Trondelag"
/collection_date="10-Aug-2009"
Protein 1..566
/product="hemagglutinin"
/function="receptor binding and fusion protein"
sig_peptide 1..17
mat_peptide 18..344
/product="HA1"
mat_peptide 345..566
/product="HA2"
CDS 1..566
/gene="HA"
/coded_by="CY051989.1:19..1719"
ORIGIN
1 mkailvvlly tfatanadtl cigyhannst dtvdtvlekn vtvthsvnll edkhngklck
61 lrgvaplhlg kcniagwilg npeceslsta sswsyivets ssdngtcypg dfidyeelre
121 qlssvssfer feifpktssw pnhdsnkgvt aacphagaks fyknliwlvk kgnsypklsk
181 syindkgkev lvlwgihhps tsadqqslyq nadayvfvgt sryskkfkpe iairpkvrxq
241 egrmnyywtl vepgdkitfe atgnlvvpry afamernags giiisdtpvh dcnttcqtpk
301 gaintslpfq nihpitigkc pkyvkstklr latglrnvps iqsrglfgai agfieggwtg
361 mvdgwygyhh qneqgsgyaa dlkstqnaid eitnkvnsvi ekmntqftav gkefnhlekr
421 ienlnkkvdd gfldiwtyna ellvllener tldyhdsnvk nlyekvrsql knnakeigng
481 cfefyhkcdn tcmesvkngt ydypkyseea klnreeidgv klestriyqi laiystvass
541 lvlvvslgai sfwmcsngsl qcrici

The sequence above is the only Norway sequence with D225G (as a mixture).