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 Post subject: Re: Two Shoes Dropping
PostPosted: Thu Dec 24, 2009 12:40 am 
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Joined: Wed Aug 19, 2009 2:33 pm
Posts: 2826
http://www.redbubble.com/people/zee1/ar ... ling-shoes

apropos picture: Two Shoes Dropping ;)


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 Post subject: Re: Two Shoes Dropping
PostPosted: Thu Dec 24, 2009 3:07 am 
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Posts: 56044
Location: Pittsburgh, PA USA
The two shoes have definitely dropped. Tamiflu resisatnce is exploding and the sequences genetocally map into a few sub-clades, indicating the H274Y is efficiently transmitting in previously healthy patients. Similarly, the sequences released today in swine in Mexico, as well as fatal cases in Mexico, demonostrate that D225G and D225N are NOT spontaneous and the number of fatal patients with D225 AND D225N just tripled (and the swine sequence also has both).

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 Post subject: Re: Two Shoes Dropping
PostPosted: Thu Dec 24, 2009 9:38 am 
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Spain - some left and right shoes reported today in several articles - :hello:
http://www.flutrackers.com/forum/showth ... 015&page=5
Re: 225G Preliminary Worldwide Tracking & Evaluation

Identified over 40 cases of mutations of the virus in Spain

MADRID, 23 Dec. (EUROPA PRESS) --


The National Epidemiological Surveillance Center of the Health Institute Carlos III reports that have already been registered in Spain more than 40 cases of mutations of the H1N1 virus causing the influenza A, including two for resistance would antiviral Tamiflu, five Similar to the first mutation found in Norway and a variant thereof, that has already been detected in 30 patients.

On 4 December, the director general of Health and Foreign Health, Ildefonso Hernandez, the first three reported cases of mutation in influenza A virus in Spain, one in a patient 66 years of Catalonia presented resistance to oseltamivir - the antiviral drug that Roche sells as' Tamiflu' - and the other two patients, also in Catalonia, with the same mutation of the virus recorded earlier in Norway, 'D222G', which caused the death of one of them.

However, the recent report of the System Influenza Surveillance in Spain on the week of 13 to 19 December, reports of new cases of mutations because, as those associated with oseltamivir resistance to reports of a registered in a girl of 14 months of the Basque Country that presented risk factors.

Both cases, he reported, were admitted to the ICU and treated with oseltamivir for five days and then, after recovery, were discharged.

As for the mutations 'D222G', the National Epidemiological Surveillance Center reports a man in Andalusia in 31 years with no history of medical complications after several died with multiorgan failure, one in Castilla La Mancha in a woman 28 years and one in Galicia in a man aged 27, from which it is unknown if had risk factors and their subsequent evolution . To these three should be added the two already known in Catalonia.

According to the report explains, "although the significance of this mutation is not fully defined, the position 222 is located in the area of cellular receptor binding and therefore the change from D to G may influence the specific virus causing the ease had more areas to infect lower respiratory tract.

Furthermore, this center under the Carlos III reports the D222E mutation, which the National Microbiology Center (NMC) has found its presence in 34 patients from Castilla-La Mancha, Ceuta, Galicia, Madrid, Melilla and Navarra . In addition, Andalusia and Asturias have identified in 6 and 1 cases respectively.

The mutation of RNA affects the viral envelope in a place near the junction of the receiver to the bronchial epithelial cell, although "the significance of this change in the receptor-binding site is highly questionable," the authors explain the report, "data from patients who have can be very helpful in trying to interpret if you have any functionality."

As explained by Professor Jose Lopez Aldeguer, member of the Spanish Society for Infectious Diseases (SEIMC), this behavior is "not unusual" and that "mutations of flu viruses are to be expected, as does each year with the seasonal" .

In any case, this expert told Europa Press that "does not seem particularly serious" as predicted by the flu season will continue unabated so far is showing in Spain.

Canary Islands, Asturias and Catalonia, the Regions More punishment

As regards the impact on the flu last week, the National Epidemiological Surveillance Center reports that the highest rate of infection in the week of 13 to 19 December, has been registered in the Canaries, with 145.08 cases per 100,000 population ; to the following Asturias (122.18), Catalonia (107.3), Castilla y Leon (95.87), Aragon (86.09), Andalusia (85.12), Extremadura (83.87), Castilla La Mancha (82.75) and Melilla (82.28).

Already below the average, which this week is 78.55 per 100,000 inhabitants, is situated the Comunidad Valenciana (70.19), Navarra (68.48), Basque Country (66.02), Cantabria (52 , 7), Ceuta (50.44), La Rioja (49.33), Baleares (48.69) and Madrid (48.24). In Galicia and Murcia are not specified in that report data.

With respect to the previous week, influenza activity stabilizes in Spain as most of the communities (to 10) indicate a stabilization of the incidence of influenza while in the remaining six (Andalucia, Baleares, Castilla La Mancha, Comunidad Valenciana , and Melilla Extremadura) shows a decrease of the same.

In the Balearic Islands, Cantabria, Navarra and La Rioja are recorded for the second straight week own flu incidence values from the pre-epidemic and six other system networks influenza incidence is situated very close to the baseline threshold. Furthermore, the level of influenza intensity is half in most of the territory under surveillance and under in Valencia, Ceuta and four networks in the north. The geographical spread of the disease is epidemic only in Murcia, in ten local networks and sporadic or none in others.

Source: europa press
http://translate.google.es/translate...ml&sl=es&tl=en


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 Post subject: Re: Two Shoes Dropping
PostPosted: Thu Dec 24, 2009 9:54 am 
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Joined: Wed Aug 19, 2009 10:42 am
Posts: 56044
Location: Pittsburgh, PA USA
Tex wrote:
As for the mutations 'D222G', the National Epidemiological Surveillance Center reports a man in Andalusia in 31 years with no history of medical complications after several died with multiorgan failure, one in Castilla La Mancha in a woman 28 years and one in Galicia in a man aged 27, from which it is unknown if had risk factors and their subsequent evolution . To these three should be added the two already known in Catalonia.

According to the report explains, "although the significance of this mutation is not fully defined, the position 222 is located in the area of cellular receptor binding and therefore the change from D to G may influence the specific virus causing the ease had more areas to infect lower respiratory tract.

http://translate.google.es/translate...ml&sl=es&tl=en

D225G:

A/Catalonia/NS092145684/2009(H1N1))"
/mol_type="viral cRNA"
/strain="A/Catalonia/NS092145684/2009(H1N1)"
/serotype="H1N1"
/isolation_source="gender:M; age:62; bronchoalveolar
lavage"
/host="human"
/db_xref="taxon:702513"
/segment="4"
/country="Spain: Catalonia"
/collection_date="10-Dec-2009"

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