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PostPosted: Wed Apr 22, 2015 9:25 am 
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USDA / CDC H5N2 Presser April 22 11 AM EDT

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PostPosted: Wed Apr 22, 2015 9:26 am 
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WASHINGTON, April 22, 2015 – Since mid-December 2014, there have been several ongoing highly pathogenic avian influenza (HPAI) H5 incidents along the Pacific, Central and Mississippi Flyways. Cases in wild birds, captive wild birds, backyard poultry or commercial poultry have been reported in Arkansas, California, Iowa, Idaho, Kansas, Minnesota, Missouri, Montana, North Dakota, Nevada, Oregon, Utah, South Dakota, Washington, Wisconsin and Wyoming.

USDA Chief Veterinary Officer John Clifford, CDC Medical Officer Dr. Alicia Fry and USDA Southeast Poultry Research Director David Swayne will provide an update on the recent outbreaks, current U.S. and State government response efforts, and research efforts underway for a vaccine.

Wednesday, April 22, 2015
11:00 a.m. – 11:45 a.m. EDT

WHAT: USDA and CDC will provide an update on current HPAI H5N2 response.

WHO: Dr. John Clifford, USDA Chief Veterinary Officer
Dr. Alicia Fry, CDC National Center for Immunization and Respiratory Diseases, Influenza Division, Epidemiology and Prevention Branch Medical Officer
Dr. David Swayne, USDA Southeast Poultry Research Lab Director

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PostPosted: Wed Apr 22, 2015 9:33 am 
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Clade 2.3.4.43 viruses were detected in birds in Canada, Germany, Italy, Japan, Netherlands, Republic of
Korea, Russian Federation, United Kingdom, USA and Viet Nam, and in birds, environmental samples
and two humans in China. There was considerable diversity in the HA genes of these clade 2.3.4.4 viruses
and in the subtype of neuraminidase (NA) with which they were paired (Figure 2). The A(H5N6/N8)
viruses isolated in China, the A(H5N6) viruses from Viet Nam and previously characterized A(H5N6)
viruses from Lao People’s Democratic Republic were antigenically diverse although ferret antisera raised
against viruses similar to A/Sichuan/26221/2014 (H5N6), from which a CVV is in development, reacted
with most viruses across this group (Table 3). The HA gene sequences of viruses isolated in Canada,
Germany, Italy, Japan, Netherlands, Republic of Korea, Russian Federation, United Kingdom, USA and
some of the viruses from China clustered together, although there was considerable diversity in the
sequences of the other viral genes. This diversity was highlighted by the introduction of the A(H5N8)
virus into North America and by subsequent reassortment with North American lineage avian viruses
generating novel A(H5N1) and A(H5N2) viruses. The antiserum raised against an
A/Sichuan/26221/2014-like virus did not react well with A(H5N2/N8) viruses isolated in the USA (Table
4). Conversely, ferret antisera raised against A/gyrfalcon/Washington/41088-6/2014 (H5N8) and
A/chicken/Kumamoto/1-7/2014 (H5N8) did not react well with the A/Sichuan/26221/2014 (H5N6)-like
virus. A new CVV based on an A/gyrfalcon/Washington/41088-6/2014-like virus is proposed.

http://www.who.int/influenza/vaccines/v ... e.pdf?ua=1

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PostPosted: Wed Apr 22, 2015 11:06 am 
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John Clifford USDA

Contain lateral spread

Wild waterfowl unique challenges

Good cooperation from states

CDC & SEPRL

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PostPosted: Wed Apr 22, 2015 11:10 am 
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Alicia Fry CDC

North American haven't caused human infections

Similar H5 have cause human

Need to be prepared for human cases

Human vaccine

Flu like symptoms or conjunctivitis

Monitoring closely

Evolving situation

http://CDC.gov/flu/avianflu/H5

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PostPosted: Wed Apr 22, 2015 11:11 am 
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David Swayne SEPRL

Diagnostic tests

Transmission studies

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PostPosted: Wed Apr 22, 2015 11:13 am 
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Animal vaccine

Seed strain

Test in chickens and turkeys

No decision on use

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PostPosted: Wed Apr 22, 2015 11:16 am 
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know virus in wild waterfowl

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PostPosted: Wed Apr 22, 2015 11:22 am 
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high winds carrying feathers or dust into barns are a possible source

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PostPosted: Wed Apr 22, 2015 11:26 am 
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ontario may be in atlantic flyway

all 4 flyways likely in fall

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