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PostPosted: Wed Jan 14, 2015 6:14 pm 
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WHO has announced the name change of clade 2.3.4.6 to clade 2.3.4.4.

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PostPosted: Wed Jan 14, 2015 6:15 pm 
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Evolution of the influenza A(H5) haemagglutinin: WHO/OIE/FAO H5 Working Group reports a new clade designated 2.3.4.4

12 January 2015

Recent detections of highly pathogenic avian influenza A(H5N8) in East Asia and Europe, A(H5N8) and A(H5N2) in North America, and A(H5N6) in East and Southeast Asia, have prompted the WHO/OIE/FAO H5 Evolution Working Group to review and update the H5 haemagglutinin (HA) clade nomenclature (1-4), which was last revised based on sequence data available prior to December 2012 (4). Although a detailed report describing the update of the existing nomenclature is in preparation, considering the high likelihood that these viruses will continue to be detected and reported, timely communication of the new clade designation is warranted. The phylogenetic analysis of H5 HA sequences from these viruses revealed extensive divergence and indicated the need to update the clade nomenclature for H5N1, H5N2, H5N5, H5N6, and H5N8 subtype viruses clustering in this HA group. After careful analysis of all available H5 sequence data, this group of HA gene segments has been designated as clade 2.3.4.4 and use of this unified classification is recommended. The virology, animal and public health communities are encouraged to adopt this clade designation for these H5 HAs and discontinue use of the provisional clade 2.3.4.6 designation, which was assigned tentatively during the WHO Vaccine Virus Consultation in September 2014 in reviewing and selecting candidate vaccine viruses of this emerging group of viruses (5).

WHO-OIE-FAO, H5 Evolution Working Group. Toward a unified nomenclature system for highly pathogenic avian influenza virus (H5N1). Emerg Infect Dis 14, e1 (2008).
WHO-OIE-FAO, H5 Evolution Working Group. Continuing progress towards a unified nomenclature for the highly pathogenic H5N1 avian influenza viruses: divergence of clade 2.2 viruses. Influenza and other respiratory viruses 3, 59-62, doi:10.1111/j.1750-2659.2009.00078.x (2009).
WHO-OIE-FAO H5 Evolution Working Group. Continued evolution of highly pathogenic avian influenza A (H5N1): updated nomenclature. Influenza Other Respi Viruses 6, 1-5, doi:10.1111/j.1750-2659.2011.00298.x (2012).
WHO-OIE-FAO H5 Evolution Working Group. Revised and updated nomenclature for highly pathogenic avian influenza A (H5N1) viruses. Influenza and other respiratory viruses 8, 384-388, doi:10.1111/irv.12230 (2014).
Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness (September 2014, http://www.who.int/influenza/vaccines/v ... update.pdf)
The WHO/OIE/FAO H5 Evolution Working Group, established in 2007, consists of representatives from international agencies (World Health Organization, World Organisation for Animal Health, and Food and Agricultural Organization) and academic institutes. Since its establishment the committee has provided a framework and regular updates for the H5 nomenclature system.

http://www.who.int/influenza/gisrs_labo ... de2344/en/

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PostPosted: Wed Jan 14, 2015 6:38 pm 
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Published Date: 2015-01-14 09:26:44
Subject: PRO/AH/EDR> Avian influenza (06): global, H5 evolution, new clade 2.3.4.4, WHO/OIE/FAO
Archive Number: 20150114.3090250
AVIAN INFLUENZA (06): GLOBAL, H5 EVOLUTION, NEW CLADE 2.3.4.4, WHO/OIE/FAO
**************************************************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Tue 13 Jan 2015
From: Ruben Donis <rvd6@cdc.gov> [edited]


Recent detections of highly pathogenic avian influenza A(H5N8) in East Asia and Europe, A(H5N8) and A(H5N2) in North America, and A(H5N6) in East and Southeast Asia have prompted the WHO/OIE/FAO H5 Evolution Working Group (with input from OFFLU) to review and update the H5 haemagglutinin (HA) clade nomenclature (Refs 1-4), which was last revised based on sequence data available prior to December 2012 (4). [For details on the membership/affiliations of the Working Group and OFFLU, see footnotes (a) and (b) in the commentary].

Although a detailed report describing the update of the existing nomenclature is in preparation, considering the high likelihood that these viruses will continue to be detected and reported, timely communication of the new clade designation is warranted. The phylogenetic analysis of H5 HA sequences from these viruses revealed extensive divergence and indicated the need to update the clade nomenclature for H5N1, H5N2, H5N5, H5N6, and H5N8 subtype viruses clustering in this HA group. After careful analysis of all available H5 sequence data, this group of HA gene segments has been designated as clade 2.3.4.4, and use of this unified classification is recommended. The virology, animal and public health communities are encouraged to adopt this clade designation for these H5 HAs and discontinue use of the provisional clade 2.3.4.6 designation, which was assigned tentatively during the WHO Vaccine Virus Consultation in September 2014 in reviewing and selecting candidate vaccine viruses of this emerging group of viruses (5).

References
1. WHO-OIE-FAO, H5 Evolution Working Group. Toward a unified nomenclature system for highly pathogenic avian influenza virus (H5N1). Emerg Infect Dis 14, e1 (2008).
2. WHO-OIE-FAO, H5 Evolution Working Group. Continuing progress towards a unified nomenclature for the highly pathogenic H5N1 avian influenza viruses: divergence of clade 2.2 viruses. Influenza and other respiratory viruses 3, 59-62, doi:10.1111/j.1750-2659.2009.00078.x (2009).
3. WHO-OIE-FAO H5 Evolution Working Group. Continued evolution of highly pathogenic avian influenza A (H5N1): updated nomenclature. Influenza Other Respi Viruses 6, 1-5, doi:10.1111/j.1750-2659.2011.00298.x (2012).
4. WHO-OIE-FAO H5 Evolution Working Group. Revised and updated nomenclature for highly pathogenic avian influenza A (H5N1) viruses. Influenza and other respiratory viruses 8, 384-388, doi:10.1111/irv.12230 (2014).
5. WHO, http://www.who.int/influenza/vaccines/v ... e.pdf?ua=1.

Submitted by "The WHO/OIE/FAO H5 Evolution Working Group."

--
Ruben Donis
Influenza Division, CDC
Atlanta, GA, USA
(on behalf of the Working Group)
<rvd6@cdc.gov>

[ProMED-mail is grateful for the above firsthand information addressing H5 haemagglutinin (HA) clade nomenclature. We are glad to be instrumental in the early distribution of the essential data to relevant virology, animal and public health communities worldwide.

The 2.3.4.4 clade seems to be widely distributed, apparently circulating in Asia, Europe as well as North America. This calls for further epidemiological investigations into the mode of spread.

(a) The WHO/OIE/FAO H5 Evolution Working Group was established in 2007. It consists of representatives from international agencies (WHO, OIE, FAO) and academic institutes. Since its establishment, the committee has provided a framework and regular updates for the H5 nomenclature system.

(b) OFFLU is the OIE-FAO network of expertise on animal influenzas, which is a global network of animal influenza experts established in 2006 to support international efforts to control animal and zoonotic influenza viruses and to reduce pandemic risks. http://www.offlu.net/. - Mod.AS]

[For a proper understanding of this announcement interested readers should access the WHO September statement, which provides the background to this recommendation and in particular for a diagram of the structure of Clade 2.3.4. [http://www.who.int/influenza/vaccines/virus/201409_zoonotic_vaccinevirusupdate.pdf]. - Mod.CP]
See Also
Avian influenza (05): Taiwan (CH) poultry, HPAI H5N8, OIE 20150112.3086713
Avian influenza (04): Taiwan (YL, PT) poultry, HPAI H5N2, new, RFI 20150112.3087008
2014
----
Avian influenza (41): South Korea, HPAI H5N8, poultry, canine susp, genotyping 20140316.2336816
2013
----
Avian influenza (05): Indonesia, duck, H5N1 2.3.2 clade 20130121.1507896
2012
----
Avian influenza (68): Indonesia (Java) duck, H5N1 2.3.2.1 clade 20121212.1448403
2011
----
Avian influenza, human (58): H5N1 2.3.2.1 clade, WHO 20110902.2682
2006
----
Avian influenza virus (02): two clades of H5N1 20060321.0886
.................................................arn/msp/cp/lm

http://www.promedmail.org/direct.php?id=3090250

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PostPosted: Wed Jan 14, 2015 7:11 pm 
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