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PostPosted: Wed Dec 24, 2014 2:18 pm 
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WHO Details 11 H7N9 Cases In China
http://www.who.int/csr/don/24-december- ... luenza/en/

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PostPosted: Wed Dec 24, 2014 2:21 pm 
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Human infection with avian influenza A(H7N9) virus – China

Disease outbreak news
24 December 2014

On 16 December 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of 11 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus, including 5 deaths.

Details of the cases are as follows

A 75-year-old male from Yancheng City, Jiangsu Province who developed symptoms on 11 November. The patient was admitted to hospital on 14 November but died on 25 November. The patient had history of exposure to live poultry.
A 68-year-old male from Urumqi City, Xinjiang Uyghur Autonomous Region who developed symptoms on 14 November. The patient was admitted to hospital on 21 November but died on 24 November. The patient had history of exposure to live poultry.
A 45-year-old male from Shihezi City, Xinjiang Uyghur Autonomous Region who developed symptoms on 15 November. The patient was admitted to hospital on 19 November but died on 27 November. The patient had history of exposure to live poultry.
A 59-year-old female from Jiaxing City, Zhejiang Province who developed symptoms on 17 November. The patient was admitted to hospital on 22 November and is now in severe condition. The patient has history of exposure to live poultry.
A 31-year-old female from Dongguan City, Guangdong Province who developed symptoms on 22 November. The patient was admitted to hospital on 25 November and is now in severe condition. The patient has history of exposure to live poultry.
An 81-year-old female from Urumqi City, Xinjiang Uyghur Autonomous Region who developed symptoms on 24 November. The patient was admitted to hospital on 27 November but died on 1 December. The patient had history of exposure to live poultry.
A 66-year-old male from Meizhou City, Guangdong Province who developed symptoms on 25 November. The patient was admitted to hospital on 27 November but died on 3 December. The patient had history of exposure to live poultry.
A 36-year-old male from Jinhua City, Zhejiang Province who developed symptoms on 26 November. The patient did not require hospitalization and is now in mild condition. The patient has history of exposure to live poultry.
A 27-year-old male from Fuzhou City, Fujian Province who developed symptoms on 26 November. The patient was admitted to hospital on 1 December and is now in severe condition. The patient has history of exposure to live poultry.
A 38-year-old male from Minghang District, Shanghai City who developed symptoms on 28 November. The patient was admitted to hospital on 1 December and is now in severe condition. The patient has history of exposure to live poultry.
A 65-year-old male from Changji Hui Autonomous Prefecture, Xinjiang Uyghur Autonomous Region who developed symptoms on 1 December. The patient was admitted to hospital on 1 December and is now in severe condition. The patient did not recall history of direct exposure to live poultry.
The Chinese Government has taken the following surveillance and control measures

Strengthen surveillance and situation analysis
Reinforce case management and medical treatment
Conduct risk communication with the public and release information.
WHO continues to closely monitor the H7N9 situation and conduct risk assessment. So far, the overall risk associated with the H7N9 virus has not changed.

WHO advice

WHO advises that travellers to countries with known outbreaks of avian influenza should avoid poultry farms, or contact with animals in live bird markets, or entering areas where poultry may be slaughtered, or contact with any surfaces that appear to be contaminated with faeces from poultry or other animals. Travellers should also wash their hands often with soap and water. Travellers should follow good food safety and good food hygiene practices.

WHO does not advise special screening at points of entry with regard to this event, nor does it currently recommend any travel or trade restrictions. As always, a diagnosis of infection with an avian influenza virus should be considered in individuals who develop severe acute respiratory symptoms while travelling or soon after returning from an area where avian influenza is a concern.

WHO encourages countries to continue strengthening influenza surveillance, including surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns, in order to ensure reporting of human infections under the IHR (2005), and continue national health preparedness actions.

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PostPosted: Wed Dec 24, 2014 4:08 pm 
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Location: Pittsburgh, PA USA
Avian Flu Scan for Dec 24, 2014
Asymptomatic H7N9 infections; Avian flu in British Columbia; Increased global flu
Filed Under: Avian Influenza (Bird Flu); H7N9 Avian Influenza; Influenza, General
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Signs of subclinical infection found in 10% of H7N9 patient contacts
Chinese researchers who tested 225 close contacts of H7N9 influenza patients found that about 10% of them carried antibodies suggesting they had been infected with the virus without getting sick, according to a letter yesterday in Emerging infectious Diseases.

The report notes that human-to-human transmission of H7N9 is not common but that reports suggest it has probably occurred in family and household clusters and between a doctor and a patient.

The researchers report that 10 H7N9 cases occurred in the city of Wuxi in Jiangu province from late March 2013 to mid-May 2014. They enrolled 225 contacts of 7 of those patients in the study, including 30 family members and 177 healthcare workers.

Hemagglutination inhibition (HI) assays were used to test for antibodies against H7N9, H5N1, H9N2, and seasonal flu viruses H1N1 and H3N2. The tests were conducted between 2 and 4 weeks after the participants' first exposure to an H7N9 patient. All contacts denied having any flu-like respiratory symptoms during the 28 days of follow-up and also denied any recent exposure to poultry or pigs or their environments, the report says.

The results showed that 22 (9.8%) contacts had elevated HI antibody titers (at least 1:40) against H7N9; titers were 1:40 for 17 contacts and 1:80 for 5 contacts. In addition, 108 contacts had HI titers of at least 1:80 against seasonal H3N2 virus, but none had titers greater than 1:80 against H5N1 and H9N2 viruses.

The authors write that one limitation of their study is that they did not collect serum samples from all contacts of infected persons or from controls, and therefore they couldn't assess the possibility of false-positive results or asymptomatic infections. Nonetheless, they say their findings "offer evidence that human-to-human transmission of H7N9 virus may occur among contacts of infected persons."
Dec 23 Emerg Infect Dis letter

http://www.cidrap.umn.edu/news-perspect ... ec-24-2014

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