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Sudan / Zaire Recombinant In DR Congo Outbreak?
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Author:  niman [ Sun Aug 24, 2014 6:39 pm ]
Post subject:  Sudan / Zaire Recombinant In DR Congo Outbreak?

Media reports describe the two confirmed Ebola cases in the Democratic Republic of the Congo (DRC) as a Sudan cases and a mixture of Sudan and Zaire, raising concerns of a recombinant.

Author:  niman [ Sun Aug 24, 2014 6:41 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

Congo declares Ebola outbreak in northern Equateur province
KINSHASA Mon Aug 25, 2014 12:42am IST

Numbi said that one of the two cases that tested positive was for the Sudanese strain of the disease, while the other was a mixture between the Sudanese and the Zaire strain -- the most lethal variety.

http://in.reuters.com/article/2014/08/2 ... R520140824

Author:  niman [ Sun Aug 24, 2014 9:52 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

The government says the samples in Congo suggest the presence of the Sudanese strain of the virus, while the West African outbreak was caused by a different strain, the Zaire strain, the most lethal form of the virus.

One of the two samples in Congo, however, was officially reported to contain a mixture of the Sudanese and Zaire strains – a claim that puzzled many Ebola analysts on Sunday.

http://www.theglobeandmail.com/life/hea ... e20187094/

Author:  alforddm [ Sun Aug 24, 2014 9:57 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

Wouldn't that require a host that is infected with both strains of the virus? It wouldn't necessarily be human however, for example a bat?

Author:  niman [ Sun Aug 24, 2014 10:00 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

However, Numbi said the infections were of a different strain than those in the outbreak in West Africa that has killed more than 1,400 people since March.

One of the two cases that tested positive was for the Sudanese strain of the disease, while the other was a mixture between the Sudanese and the Zaire strain - the most lethal variety, the health official said.

The outbreak in West Africa is the Zaire strain.

http://www.aljazeera.com/news/africa/20 ... 61469.html

Author:  niman [ Mon Aug 25, 2014 5:52 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

A New Strain Of Ebola Emerges In Democratic Republic Of Congo
August 25, 2014 4:06 PM ET
Listen to the Story
All Things Considered 4 min 14 sec
A new outbreak of Ebola is being reported in the Democratic Republic of Congo. But scientists say it's not related to the Ebola epidemic going on in West Africa.

http://www.npr.org/2014/08/25/343172439 ... rm=nprnews

Author:  niman [ Mon Aug 25, 2014 5:52 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?


http://www.npr.org/player/v2/mediaPlaye ... =343203851

Author:  niman [ Mon Aug 25, 2014 9:48 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

DRC says its Ebola outbreak not linked to West Africa's

Filed Under: Ebola; VHF

Robert Roos | News Editor | CIDRAP News | Aug 25, 2014

Ebola has struck an area in the northern part of the Democratic Republic of Congo (DRC), with at least two confirmed fatal cases, but authorities say it is not the same strain as in West Africa, according to media reports and the World Health Organization (WHO).

DRC Health Minister Felix Kabange Numbi announced on state television yesterday that 2 of 8 samples from patients in Djera, in the Boende region of Equateur province, tested positive for Ebola, according to an Associated Press (AP) report yesterday. The story described the cases as fatal.

Kabange said officials believe Ebola has killed 13 people in the region, including five health workers, according to the story. He said 11 people were sick and in isolation and that 80 contacts were being traced.

"This epidemic has nothing to do with the one in West Africa," Kabange said.

Further test results expected

The DRC's national laboratory reported that the Ebola strain is different from the one causing the epidemic in West Africa, the WHO said on Twitter yesterday. The agency said the government is "organizing" further tests to better characterize the strain.

More test results were expected today, WHO spokesman Gregory Hartl said yesterday on Twitter. He said there "could be 2 different strains here, meaning two different events/outbreaks."

The WHO said earlier that an outbreak of hemorrhagic gastroenteritis was the cause of 70 deaths in the Boende region in recent weeks. In Twitter comments last week, Hartl said those deaths were not from Ebola, but yesterday he tweeted that he had been given "premature information from the field." He said samples had tested positive in the DRC lab and the tests would be checked by another lab.

DRC's seventh Ebola outbreak

Djera is a collection of villages more than 1,200 kilometers (745 miles) from the DRC capital, Kinshasa, and more than 600 kilometers from the provincial capital, Mbandaka, the AP reported.

Confirmation of Ebola prompted the DRC to deploy a response team to the affected area immediately, working with the WHO and other partners, the WHO said yesterday.

The DRC has had six previous Ebola outbreaks since the disease was discovered there in 1976, according to WHO data.

See also:

Aug 24 AP story

WHO on Twitter

Gregory Hartl on Twitter

WHO fact sheet on Ebola virus disease
http://www.cidrap.umn.edu/news-perspect ... st-africas

Author:  niman [ Tue Aug 26, 2014 4:24 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

No. 2
August 25, 2014
1 Location of the disease
 Declaration of the epidemic by the Minister of Public Health August 24, 2014
 13 people died of the disease (CFR 54%), including five health workers, about 24 cases
suspects (16 women and 8 men)
 11 people segregated
 24 cases (16 women and 8 men) of Ebola virus disease outbreak in the area of health
Boende, from July 28 to August 18, 2014
 80 contacts identified for monitoring
 4 positive samples from eight after a second analysis INRB
 565 suspected cases investigated with gastroenteritis, diarrhea and vomiting.
 Index case identified Ikanamongo (100 km Boende): a woman who died on August 11 after
consuming bushmeat hunted by her husband and that has contaminated your doctor and
 yet unidentified strain between Zaire and Sudan. Awaiting the results from the
laboratory in Franceville (Gabon).
 No link between the epidemic of West Africa, given the remoteness of the area.
 7th epidemic since 1976, when the discovery of the disease in the DRC
 No cases reported in Kinshasa or Mbandaka
2 information on the disease
 Case fatality rate can reach 90%.
 Transmission to humans from wild animals and then spread in populations
by human transmission
 No vaccine or specific treatment approved, either for humans or animals.
3 Geography places
 Zone enclave, surrounded by two rivers
 four health areas involved in the health zone Boende at 1200 km from Kinshasa
4 Needs and gaps
 Partner support for various components
 Health: taking care of patients
 Food Security: Food for banned people hunting
 Water and sanitation: drinking water, hygiene awareness, chlorination
 Logistics: transport personnel, inputs and accommodation and assembly areas
 Funding contingency plan (see below)
5 Response and system set up
5.1. activities carried out
 Establishing a quarantine area of 100 km around Djera, place of origin of the disease:
travel ban for 30 000 to 40 000 people
 Sending a flight MSF cargo loaded this August 25 to Boende
 Distribution WHO PPE Kit in four health areas, the general referral hospital
Boende and Mbandaka, capital of the province
Office for the Coordination of Humanitarian Affairs of the United Nations
Losonia building, Boulevard du 30 Juin, BP 7248 Kin1, Common Gombe, Kinshasa, Democratic Republic of Congo
 Setting up a Technical and Scientific International Committee (CITS)
 Installing a mobile laboratory Boende
 Committee revived crisis
 Plan for Preparedness and Response developed (contingency) developed by the Ministry of Health
Public and partners
 Epidemiological surveillance and early warning reinforced at points of entry and throughout the country
 personal protective kits pre-positioned in all provinces (County seat)
 Prohibition of hunting throughout the entire District Tshuapa
5.2. Current Actions
 Installing a thermal laser at all airports in the country to measure the temperature of
 Installation of a mobile laboratory in the epicenter of Lokolia, about 200 km from Mbandaka
diagnose the virus in real time
 Printing posters for extension for hygiene
 Acquisition of additional inputs for the next 3 months: 25 Emergency Health Kits; 100
Additional PPE kits; Barrels 45 5 kg of chlorine; 10 sampling kits; 1000 triple
Class A packaging; Inputs laboratory
 information and population education program implementation
 Measures of hospital hygiene and infection control strengthened
 Deploying additional national experts
 Setting up a call center (with toll)
 Establishment of a focal humanitarian point coordinated by OCHA with WHO and UNICEF
6 Financing contingency plan
 USD 1.5 million from the Government of the DRC (Free)
 USD 1,500,000 million from the Pooled Fund (Free)
 USD 1.5 million CERF Rapid Response (call)
 USD 200,000 to UNICEF (Free)
 USD 200,000 UNDP (call)
 Amount to be determined by the World Bank
7 Security
 UNDSS is in discussions with WHO to take the necessary steps to
movement of UN officials.
8 Stakeholders
 Ministry of Public Health
 Ministry of Interior, Decentralization and customary Affairs
 Ministry of Social Affairs, Humanitarian Action and National Solidarity
 ECHO (PUC funding MSF)
 DFID (PUC funding MSF)
 World Bank

http://www.rdc-humanitaire.net/attachme ... %2025%20août%202014%20-%20No.%202_26082014.pdf

Author:  morning [ Tue Aug 26, 2014 7:45 pm ]
Post subject:  Re: Sudan / Zaire Recombinant In DR Congo Outbreak?

For the benefit of the non-initiates in virology - I can understand the danger of a H5N1 Ebola recombinant, but not much of two Ebola strains. What is exactly the worst case here?

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