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PostPosted: Tue Aug 26, 2014 8:04 pm 
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morning wrote:
For the benefit of the non-initiates in virology - I can understand the danger of a H5N1 Ebola recombinant, but not much of two Ebola strains. What is exactly the worst case here?

H5N1 and Ebola recombination is not likely because the various components have to be compatible and offer an advantage. However, recombination between two distinct clades like Zaire and Sudan might offer a decided advantage with regard to transmission or adaptation to humans.

Ebola is already adapted to mammals, since its natural host is likely bats. It kills primates, including humans, which is how the Congo outbreak was said to have started (husband killed an Ebola infected monkey which they ate).

The numbers in DRC are VERY high, especially if some or most of the 565 suspect cases are infected. It is very unusual to have this many cases prior to confirmation of the first case, which happened Sunday.

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PostPosted: Tue Aug 26, 2014 8:23 pm 
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There wouldn't be danger of the recombinant strain being airborne though would there? Since neither of the existing two strains are currently airborne? Wouldn't it just be a splicing of the two existent strains or is it more complicated than that?


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PostPosted: Tue Aug 26, 2014 8:26 pm 
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alforddm wrote:
There wouldn't be danger of the recombinant strain being airborne though would there? Since neither of the existing two strains are currently airborne? Wouldn't it just be a splicing of the two existent strains or is it more complicated than that?


Recombinant should reflect properties in parental strains, but no sequences have been released yet, so info on parental strains is sketchy.

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PostPosted: Tue Sep 02, 2014 7:57 pm 
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Now, a sequence of 346 base pairs of one of the virus's genes has shown that the two outbreaks aren't directly related. The fragment has seven mutations compared with genomes from the current outbreak in Guinea, but only four mutations compared with the strain that caused the first known Ebola outbreak in 1976, also in the DRC, which was then named Zaire. It is even more closely related—by just three mutations—to the strain that caused an outbreak in the DRC city of Kikwit in 1995. Leroy says he hopes to have a full genome sequence of the new DRC strain by the end of this week.

http://news.sciencemag.org/health/2014/ ... n-epidemic

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PostPosted: Tue Sep 02, 2014 8:02 pm 
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niman wrote:
Now, a sequence of 346 base pairs of one of the virus's genes has shown that the two outbreaks aren't directly related. The fragment has seven mutations compared with genomes from the current outbreak in Guinea, but only four mutations compared with the strain that caused the first known Ebola outbreak in 1976, also in the DRC, which was then named Zaire. It is even more closely related—by just three mutations—to the strain that caused an outbreak in the DRC city of Kikwit in 1995. Leroy says he hopes to have a full genome sequence of the new DRC strain by the end of this week.

http://news.sciencemag.org/health/2014/ ... n-epidemic

346 BP certainly would NOT exclude recombination or Sudan sequences.

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