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PostPosted: Mon Aug 25, 2014 8:25 am 
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Liberian doctor who received rare Ebola drug ZMapp dies
DAKAR Mon Aug 25, 2014 5:30pm IST

(Reuters) - One of three African doctors infected with Ebola and treated with the experimental drug ZMapp has died in Monrovia, Liberia's Information Minister Lewis Brown said on Monday.

Asked to confirm the death of doctor Abraham Borbor, Brown said: "That is correct. He died yesterday."

http://in.reuters.com/article/2014/08/2 ... 0C20140825

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PostPosted: Mon Aug 25, 2014 8:29 am 
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MONROVIA, August 25- A Liberian doctor treated with experimental American anti-Ebola serum ZMapp has died, the west African nation said on Monday.

Abraham Borbor had been improving but died on Sunday night, Liberian Information Minister Lewis Brown told AFP.

“He was showing signs of progress but he finally died. The government regrets this loss and extends its condolences to the bereaved family,” Brown said.

Two other health workers receiving the serum are still in treatment, said the minister, adding that there were “signs of hope”.

The World Health Organization (WHO) said on Thursday there had been a “significant improvement” in the condition of a doctor and nurse being treated with ZMapp in Liberia, and that another doctor was getting better, but still in a serious condition.


Liberia took delivery of ZMapp on August 13 from the United States, which gave the serum to two US citizens who were declared cured last week.

The Americans were infected in Liberia along with a Spanish priest who died on August 12, despite also receiving ZMapp.

The very small available stocks of ZMapp, which has never been through clinical trials on humans, have now been used up, according to the lab that produces it.

The WHO has been discussing the use of unapproved drugs as a way of getting a handle on an outbreak in Africa that has already cost more than 1,400 lives.

There is currently no available cure or vaccine for Ebola, but several drugs are under development.

Tokyo said on Monday it was ready to offer an experimental drug developed by a Japanese company to help stem the global tide of Ebola.

Avigan, which is taken in tablet form, was approved as an anti influenza drug in Japan in March and is currently in clinical tests in the United States.

A panel of medical experts convened by the WHO earlier this month determined it was “ethical” to provide experimental treatments, given the scale of the epidemic.

http://www.capitalfm.co.ke/news/2014/08 ... drug-dies/

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PostPosted: Mon Aug 25, 2014 9:05 pm 
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WHO: Medical worker infections and shortages hamper Ebola response

Filed Under: Ebola

Lisa Schnirring | Staff Writer | CIDRAP News | Aug 25, 2014


Two medical workers assisting with the Ebola outbreak response in Sierra Leone have been sickened by the disease, one of them deployed by the World Health Organization (WHO) and the other a British nurse who was airlifted to a London hospital for treatment.

News of two more infected aid workers comes as the WHO today expressed heightened concerns about the impact the outbreak is having on health workers battling the disease and obstacles the infections pose to getting enough workers from overseas to staff treatment centers.

Response worker infections

According to media reports, the WHO-deployed health worker is an epidemiologist from Senegal. The WHO said on its Twitter feed that the worker is with the Global Outbreak Alert and Response Network (GOARN). In a statement yesterday the WHO said it was working to ensure that the patient, who got sick in Sierra Leone, has the best care possible, with the option of medical evacuation if needed.

The health worker was in Kailahun district tracing Ebola virus disease (EVD) cases, according to Politico SL, a newspaper based in Sierra Leone. The district has been one of Sierra Leone's EVD hot spots.

The WHO said it has so far deployed about 400 staff members of its own and from partner organizations, and the patient is the first of that number to be infected in the outbreak. It added that it recognized the risk Ebola virus poses to health workers and takes many precautions before they deploy to help them protect themselves in the field.

Meanwhile, Public Health England (PHE) yesterday said a British national living in Sierra Leone has been diagnosed with EVD and is being medically evacuated to the United Kingdom, to be treated in an isolation unit at the Royal Free NHS Foundation hospital in London. It said the patient was not currently in serious condition.

John Watson, MBBS, MSc, PHE's deputy chief medical officer, said in the statement that the UK has a robust, well-tested system for handling unusual infectious diseases and that the country's hospitals have a proven record of managing imported infectious diseases. "This patient will be isolated and will receive the best care possible."

The PHE said it would provide no other details about the patient, to protect the patient's privacy. However, according to a media report, the patient is a man who has been working as a volunteer nurse at Kenema Government Hospital over the last 3 months.

The British patient is the fifth medical worker to be flown out of West Africa because of EVD. The others are two Americans who worked for a Christian missionary group, both of whom have recovered, a Spanish priest who died from his infection, and a Spanish nun who reportedly did not have EVD.

WHO details burden on workers, outbreak challenges

The WHO today singled out the high burden the disease has had on health workers as one of the outbreak's unprecedented features. More than 240 healthcare workers have been sickened by Ebola virus disease (EVD) in the four West African countries affected by the event, the agency said. More than half of them have died. Among them have been some of the top doctors in Liberia and Sierra Leone.

Several factors explain the high toll the disease is taking on medical staff, the WHO said. They include shortages and improper use of personal protective equipment (PPE), too few medical staff to respond to the outbreak, and compassion that prompts health workers to work in isolation wards beyond the number of hours recommended for safety reasons.

Aside from shortages, the PPE is hot and cumbersome, especially in tropical climates, pushing clinicians beyond their physical limits, with some working 12-hour shifts. "Staff who are exhausted are more prone to make mistakes," the WHO said.

Medical staff and the people in West Africa aren't familiar with EVD, given that the current outbreak is the region's first, the WHO said. Also, other diseases in the area such as malaria have symptoms that often resemble the initial symptoms of EVD, and patients often seek emergency care in settings where doctors and nurses don't initially suspect Ebola and aren't taking protective measures against the disease.

The heavy toll on medical staff is complicating response efforts, because it not only depletes personnel who can treat sick patients, but also makes it difficult for the WHO to secure foreign workers to come to West Africa to help with the outbreak. The WHO added that the African Union has launched an urgent push to recruit more health workers from its member countries.

CDC advice for humanitarian workers

In view of the risk to health workers and other outbreak responders, the US Centers for Disease Control and Prevention (CDC) on Aug 23 issued advice for humanitarian workers traveling to the outbreak countries to assist with the EVD response. It urged people planning trips to the region to consult a travel medicine doctor beforehand to discuss individual recommendations based on medical history and travel plans.

The CDC said humanitarian workers should pack a basic first aid kit. If they expect to work in a healthcare setting where close contact with EVD patients could occur, travelers should ensure that the organization will provide PPE, and if not, workers should pack them and bring them along. It urged workers to check their health insurance plans, or those of their organization, and to purchase one if not fully covered. Workers should also ask organizations about medical evacuation plans.

The CDC's advice also covers special recommendations for health workers, what to do if a worker gets sick during the trip, and what steps to take when returning to the United States.

Alternative treatment developments

In other medical developments, an official from Liberia's health ministry said today that a doctor who received the experimental EVD drug ZMapp has died, Agence France-Presse (AFP) reported. The country's information minister, Lewis Brown, told AFP that the doctor had been improving, but died last night. Two other health workers who received the drug are still being treated and show encouraging signs.

A WHO ethics panel has given the green light to the use of experimental drugs and vaccines in the outbreak, but it has also warned that supplies are extremely limited and that the therapies aren't expected to have an impact on the course of the outbreak. However, the group will host a meeting in Geneva on Sept 4 and 5 to discuss the most promising treatments, safety and efficacy issues, and possible ways to speed up clinical trials.

Meanwhile, Japan's government today said it can provide a Japanese-developed antiviral drug, if the WHO requests it, the Associated Press (AP) reported yesterday. The drug favipiravir is approved in Japan for treating new and reemerging influenza viruses.

Chief Cabinet Secretary Yoshihide Suga said Japan is watching for more details from the WHO on the use of untested drugs and in the case of an emergency can respond to individual requests before any decisions from WHO.

The drug's developer, Toyama Chemical Co., a subsidiary of Fujifilm, is talking with the US Food and Drug Administration (FDA) about clinical tests of the drug for treating EVD, a company spokesman told the AP. The company has enough of the drug to treat 20,000 patients.

See also:

Aug 25 WHO Ebola situation assessment

Aug 24 WHO statement

Aug 24 Politico SL story

Aug 24 PHE statement

Aug 23 CDC advice for humanitarian workers

Aug 25 AFP story

Aug 24 AP story

http://www.cidrap.umn.edu/news-perspect ... a-response

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