I am not a very good writer.
I am not asking you to push them into alkalosis, but keep them "slightly alkaline"
and as you must know, human blood ideally when normal is THAT. "Slightly Alkaline".
As stated, too far either way and you will have issues. However, this virus, will over time create a more acidic environment for itself.
AND, in those that already were a bit acidic in the first place, it would stand to reason, could very well carry a bigger viral load as the virus was in a more "happy environment" for a longer period of time.
Think about it, what OTHER connection do you see between these most hard hit mortality groups? Ashthma, diabetics, smokers, late term pregnancy, folks that have metabolic issues that make is so they cant stay in the ideal state of "slightly alkaline".
You were correct, when you used the term "normalize".
Tell me, what measures do they take to monitor this PH when you do have patients with ARDS etc and who are on mechanical ventilation? How often are they testing, and how successful are they are "normalizing" the PH?
What I would really like to know, is what the PH is in the actual lung cells in both high risk patients as well as normal healthy adults PRIOR to infection.
Then do a direct comparison post infection.
Now that would be good information but nearly impossible to get. If I had animal models I would be able to demonstrate more. Right now its all based on theory and a pretty solid understanding basic enzymology (in which PH dictates "on off" for many processes) And many enzymes work in very narrow range of course.
Basically and simply put, the viral infection of the lungs will tend to put people in "acidosis".
And as a result I would not be surprised to see many "symptoms" of the virus be equal to those you would see from symptoms of "acidosis".
And I would bet money that many of these mortalities had very little done in which establishing "normal" slightly alkaline PH was successful.
From some of the papers I have read it could very well be doctors are trying to keep them in a slight state of acidosis to help o2 transfer like in that published study with uninfected elderly. And I think that would be exactly what would make this virus happy. So far as I have seen ECMO seems the best option for these folks going onto mechanical ventilation. Help them get the CO2 OUT. But at the same time, it would make sense to try to normalize their PH. Tell me what IV fluids are they usually using on these people in ICU?
But of course until someone opens their minds, and tries it on some ferrets etc its all speculation of course.
I only have 32 co-authored scientific publications at this time but they are certainly not in influenza. This is a crash course for me, so I really appreciate your input on everything:)
I am basically a biochemist and enzymologist, however I do work with pathogens. I have no way to do In-vivo here.
I know it sounds simple.
Almost TOO simple. But think about the hard hit mortality groups.
I would bet nearly all of them, were an ideal candidate for some form of even slight acidosis due to their condition before the virus infected them. They were a very Happy Home for the virus to do its thing. As opposed to a healthy person in a normal slightly alkaline state in which the virus could infect, but would not do as well......
The Happy Speculative Scientist